Modulation of auditory responses by visual inputs in the mouse auditory cortex

Sharma, Sudha; Srivastava, Hemant; Bandyopadhyay, Sambaran

doi:10.1101/2021.01.22.427870

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…While doing this, we recorded activity in L2/3 neurons of ACx using two-photon calcium imaging. Using this approach, we first confirmed that a substantial subset of L2/3 neurons in ACx responds to either auditory, visual (Sharma et al, 2021), or motor-related inputs (Henschke et al, 2021; Morandell et al, 2023; Vivaldo et al, 2023). While we found that L2/3 neurons in ACx responded to audiomotor mismatches in a way that closely resembles visuomotor mismatch responses found in V1 (Keller et al, 2012), we found no evidence of responses to visuomotor mismatch in ACx.…”

Section: Introductionmentioning

confidence: 75%

“…Consistent with previous reports, we found that auditory, visual, and motor-related signals are intermixed in the population of L2/3 neurons in ACx. Responses to both motor-related (McGinley et al, 2015; Schneider et al, 2014; Vivaldo et al, 2023; Yavorska and Wehr, 2021; Zhou et al, 2014) and visual signals (Bigelow et al, 2022; Morrill and Hasenstaub, 2018; Sharma et al, 2021) have been reported across layers in ACx, with the strongest running modulation effect found in L2/3 (Schneider et al, 2014). Also, consistent with previous reports, we found that a subset of L2/3 neurons in ACx respond to audiomotor prediction errors (Audette et al, 2022; Liu and Kanold, 2022).…”

Section: Discussionmentioning

confidence: 99%

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Multimodal mismatch responses in mouse auditory cortex

Solyga,

Keller

2023

Preprint

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SUMMARYOur movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual sensory input, primary sensory areas of cortex have been shown to compute sensorimotor prediction errors. How prediction errors in one sensory modality influence the computation of prediction errors in another modality is still unclear. To investigate multimodal prediction errors in mouse auditory cortex (ACx), we used a virtual environment to experimentally couple running to both self-generated auditory and visual feedback. Using two-photon microscopy, we first characterized responses of layer 2/3 (L2/3) neurons to sounds, visual stimuli, and running onsets and found responses to all three stimuli. Probing responses evoked by audiomotor mismatches, we found that they closely resemble visuomotor mismatch responses in visual cortex (V1). Finally, testing for cross modal influence on audiomotor mismatch responses by coupling both sound amplitude and visual flow speed to the speed of running, we found that audiomotor mismatch responses were amplified when paired with concurrent visuomotor mismatches. Our results demonstrate that multimodal and non-hierarchical interactions shape prediction error responses in cortical L2/3.

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Section: Introductionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Multimodal mismatch responses in mouse auditory cortex

Solyga,

Keller

2023

Preprint

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“…We first performed widefield Ca 2+ imaging 55,56 (see Methods) to identify location of A1 with UF 57,58 and other auditory areas 59 (Fig. 5A).…”

Section: Somatostatin (Som) Positive Interneurons and Thy-1 Excitatory Neurons Behave Differentially During Observed Experience Dependentmentioning

confidence: 99%

Social experience dependent plasticity of mouse song selectivity without that of song components

Agarwalla

Bandyopadhyay

2021

Preprint

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Syllable sequences in male mouse ultrasonic-vocalizations (USVs), “songs”, contain structure -quantified through predictability, like birdsong and aspects of speech. Apparent USV innateness and lack of learnability, discount mouse USVs for modelling speech-like social communication and its deficits. Informative contextual natural sequences (SN) were theoretically extracted and they were preferred by female mice. Primary auditory cortex (A1) supragranular neurons show differential selectivity to the same syllables in SN and random sequences (SR). Excitatory neurons (EXNs) in females showed increases in selectivity to whole SNs over SRs based on extent of social exposure with male, but syllable selectivity remained unchanged. Thus mouse A1 single neurons adaptively represent entire order of acoustic units without altering selectivity of individual units, fundamental to speech perception. Additionally, observed plasticity was replicated with silencing of somatostatin positive neurons, which had plastic effects opposite to EXNs, thus pointing out possible pathways involved in perception of sound sequences.

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Multimodal Mismatch Responses in Mouse Auditory Cortex

Solyga,

Keller

2024

Preprint

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Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual sensory input, primary sensory areas of cortex have been shown to compute sensorimotor prediction errors. How prediction errors in one sensory modality influence the computation of prediction errors in another modality is still unclear. To investigate multimodal prediction errors in mouse auditory cortex (ACx), we used a virtual environment to experimentally couple running to both self-generated auditory and visual feedback. Using two-photon microscopy, we first characterized responses of layer 2/3 (L2/3) neurons to sounds, visual stimuli, and running onsets and found responses to all three stimuli. Probing responses evoked by audiomotor mismatches, we found that they closely resemble visuomotor mismatch responses in visual cortex (V1). Finally, testing for cross modal influence on audiomotor mismatch responses by coupling both sound amplitude and visual flow speed to the speed of running, we found that audiomotor mismatch responses were amplified when paired with concurrent visuomotor mismatches. Our results demonstrate that multimodal and non-hierarchical interactions shape prediction error responses in cortical L2/3.

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Modulation of auditory responses by visual inputs in the mouse auditory cortex

Cited by 5 publications

References 48 publications

Multimodal mismatch responses in mouse auditory cortex

Multimodal mismatch responses in mouse auditory cortex

Social experience dependent plasticity of mouse song selectivity without that of song components

Multimodal Mismatch Responses in Mouse Auditory Cortex

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