No abstract

A one- and two-photon activated photoremovable protecting group (PRPG) was designed based on a carbazole fused o-hydroxycinnamate platform for the dual (same or different) release of alcohols. The mechanism for the dual release proceeds through a stepwise pathway and also monitors the first and second photorelease in real time by an increase in fluorescence intensity and color change, respectively. Further, its application in staining live neurons and ex vivo imaging with two-photon excitation is shown.

Learning a Spatial Task by Trial and Error in Drosophila Highlights d Flies possess ''reward'' neurons with properties similar to those of the vertebrate MFB d Closed-loop stimulation of these neurons enables flies to learn a spatial task d Flies' learning is influenced both by vision and non-visual features in the arena d Learning is enabled by specific DA and ChAT neurons as well as MB and CX in the brain

Parallel lemniscal and non-lemniscal sources control auditory responses in the orbitofrontal cortex (OFC)

Alzheimer's disease (AD) is one of the most devastating diseases currently in the world with no effective treatments. There is increasing evidence that the gut microbiome plays a role in AD. Here we set out to study the age-related changes in the microbiome of the Tgf344-AD rats. We performed 16S ribosomal RNA sequencing on the fecal samples of male rats at 14 and 20 months of age. We found the Tgf344-AD rats to have decreased microbial diversity compared to controls at 14 months of age and this was found to be opposite at 20 months of age. Interestingly, we found a distinctive shift in the microbial community structure of the rats with aging along with changes in the microbiota composition. Some of the observed changes in the Tgf344AD rats were in the genera Bifidobacterium, Ruminococcus, Parasutterella, Lachnoclostridium and Butyricicoccus. Other age-related changes occuring in both the Tgf344-AD and WT control rats were decreases in Enterohaldus, Escherichia Shigella, Rothia and increase in Turicibacter and Clostrium_senso_stricto. Our study has shown that gut microbiota changes occurs in this Alzheimer's disease rat model.www.aging-us.com AGINGC. difficile infection [12]. These studies posit a view that gut microbiome modulation could be a potential therapy for treating AD.