Modulation of cerebral malaria by curcumin as an adjunctive therapy

Jain, Kunal; Sood, Sumeet; Kuppusamy, Gowthamarajan

doi:10.1016/j.bjid.2013.03.004

Cited by 37 publications

(30 citation statements)

References 107 publications

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“…Phytochemical profile of A. nepalensis leaves extracts demonstrated that diarylheptanoids is a major class of compound present in sufficient quantity (Yadav et al, ). Curcumin, one of the diarylheptanoid isolated from Curcuma longa , has been extensively studied against malaria pathogenesis (Haddad et al, ; Jain et al, ).…”

Section: Discussionmentioning

confidence: 99%

Diarylheptanoids Rich Fraction ofAlnus nepalensisAttenuates Malaria Pathogenesis:In-vitroandIn-vivoStudy

et al. 2016

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Diarylheptanoids from Alnus nepalensis leaves have been reported for promising activity against filariasis, a mosquito-borne disease, and this has prompted us to investigate its anti-malarial and safety profile using in-vitro and in-vivo bioassays. A. nepalensis leaf extracts were tested in-vitro against chloroquine-sensitive Plasmodium falciparum NF54 by measuring the parasite specific lactate dehydrogenase activity. Among all, the chloroform extract (ANC) has shown promising anti-plasmodial activity (IC50 8.06 ± 0.26 µg/mL). HPLC analysis of ANC showed the presence of diarylheptanoids. Efficacy and safety of ANC were further validated in in-vivo system using Plasmodium berghei-induced malaria model and acute oral toxicity in mice. Malaria was induced by intra-peritoneal injection of P. berghei infected red blood cells to the female Balb/c mice. ANC was administered orally at doses of 100 and 300 mg/kg/day following Peter's 4 day suppression test. Oral administration of ANC showed significant reduction of parasitaemia and increase in mean survival time. It also attributed to inhibition of the parasite induced pro-inflammatory cytokines as well as afford to significant increase in the blood glucose and haemoglobin level when compared with vehicle-treated infected mice. In-vivo safety evaluation study revealed that ANC is non-toxic at higher concentration. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Diarylheptanoids Rich Fraction ofAlnus nepalensisAttenuates Malaria Pathogenesis:In-vitroandIn-vivoStudy

et al. 2016

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“…This represents an enormous burden of disease, due to the high prevalence of infection (Jain et al, 2013a). It is characterized by impaired consciousness, seizures, hallucinations, severe metabolic acidosis, jaundice, renal failure and respiratory distress (Beales et al, 2000;Maitland & Newton, 2005).…”

Section: Introductionmentioning

confidence: 99%

Optimization of artemether-loaded NLC for intranasal delivery using central composite design

Jain¹,

Sood²,

Kuppusamy³

2014

Drug Delivery

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The objective of the study was to optimize artemether-loaded nanostructured lipid carriers (ARM-NLC) for intranasal delivery using central composite design. ARM-NLC was prepared by microemulsion method with optimized formulation having particle size of 123.4 nm and zeta potential of À34.4 mV. Differential scanning calorimetry and powder X-ray diffraction studies confirmed that drug existed in amorphous form in NLC formulation. In vitro cytotoxicity assay using SVG p12 cell line and nasal histopathological studies on sheep nasal mucosa indicated the developed formulations were non-toxic and safe for intranasal administration.In vitro release studies revealed that NLC showed sustained release up to 96 h. Ex vivo diffusion studies using sheep nasal mucosa revealed that ARM-NLC had significantly lower flux compared to drug solution (ARM-SOL). Pharmacokinetic and brain uptake studies in Wistar rats showed significantly higher drug concentration in brain in animals treated intranasally (i.n.) with ARM-NLC. Brain to blood ratios for ARM-NLC (i.n.), ARM-SOL (i.n.) and ARM-SOL (i.v.) were 2.619, 1.642 and 0.260, respectively, at 0.5 h indicating direct nose to brain transport of ARM. ARM-NLC showed highest drug targeting efficiency and drug transport percentage of 278.16 and 64.02, respectively, which indicates NLC had better brain targeting efficiency compared to drug solution.

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“…In children, seizures are most commonly occurring after the sudden onset of coma, whereas in adults a seizure is related to gradually developed coma [37]. Seizures represent 80% of African children of cerebral malaria symptoms [34,35].…”

Section: Malariamentioning

confidence: 99%

Parasites in central nervous system

Mohamed¹,

Mansour²

2017

IJMDC

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Parasites are different organisms that can be classified into single-cell organisms and multicellular organisms. Complications caused by parasites affect both children and adults in high number. Some parasites cause diseases with symptoms and other cause no symptoms. Parasites can be present in unusual places such as in central nervous system (CNS). The parasitic infections of CNS are sources of mortality and morbidity.

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Modulation of cerebral malaria by curcumin as an adjunctive therapy

Cited by 37 publications

References 107 publications

Diarylheptanoids Rich Fraction ofAlnus nepalensisAttenuates Malaria Pathogenesis:In-vitroandIn-vivoStudy

Diarylheptanoids Rich Fraction ofAlnus nepalensisAttenuates Malaria Pathogenesis:In-vitroandIn-vivoStudy

Optimization of artemether-loaded NLC for intranasal delivery using central composite design

Parasites in central nervous system

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