Optimization of artemether-loaded NLC for intranasal delivery using central composite design

Jain, Kunal; Sood, Sumeet; Kuppusamy, Gowthamarajan

doi:10.3109/10717544.2014.885999

Cited by 126 publications

(78 citation statements)

References 59 publications

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“…While 83.53% of loaded 25.19% (amount of drug entrapped in NLC) was considered to be the maintenance dose (towards sustained delivery). Further, the desired polynomial equations, showed a good fit of responses at different concentrations (table 6), thereby supporting the significance of the said model [29].…”

Section: Effect Of Dependent Variables On Responsessupporting

confidence: 65%

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Ziprasidone Hydrochloride Loaded Nanostructured Lipid Carriers (Nlcs) for Intranasal Delivery: Optimization and in Vivo Studies

et al. 2019

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Objective: The present study was an attempt to systemically deliver the most desirable schizophrenia drug, ziprasidone hydrochloride (ZRS) via the intranasal route using nanostructured lipid carrier (NLC) approach. Methods:The desired ZRS loaded NLCs were developed using central composite statistical design and the developed formulation was monitored for improving ZRS bioavailability and their brain targeting efficacy.Results: Pharmacokinetic studies revealed a 10 fold increase (ZRS blood-brain ratio) for NLCs administered through nasal route (in comparison to intravenous route). Similarly, the concentration of ZRS (in the brain) delivered via nasal route exhibits 4 fold increment at all-time points.Conclusion: Therefore, the obtained results suggest a potential nose to brain transport of loaded ZRS by effective bypassing of the Blood-Brain Barrier (BBB). I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

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Section: Effect Of Dependent Variables On Responsessupporting

confidence: 65%

“…) as independent variables, while levels-1 and+1 were chosen as low and high, whereas 0 was chosen as the centre point [29]. .…”

Section: Effect Of Dependent Variables On Responsesmentioning

confidence: 99%

Ziprasidone Hydrochloride Loaded Nanostructured Lipid Carriers (Nlcs) for Intranasal Delivery: Optimization and in Vivo Studies

et al. 2019

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“…The heating and cooling rates were 10 C/min and 150 C/min, respectively. All thermal measurements were performed over 40-400 C under a nitrogen purge of 50 ml/min (Sood et al, 2013;Jain et al, 2014).…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

A novel vesicular transdermal delivery of nifedipine – preparation, characterization andin vitro/in-vivoevaluation

et al. 2014

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Nifedipine is a calcium channel blocker extensively used in the treatment of anginal and hypertension. On oral administration it undergoes extensive first pass metabolism, which outweighs its absorbance through gastrointestinal tract (GIT) and bioavailability of the drug in systemic circulation. As an alternative to oral route transdermal route of drug delivery was developed. In the present investigation, proniosomes are prepared by varying the ratio of span-40, lecithin, aqueous phase and polymer. Formulation containing span-40, lecithin, isopropyl alcohol, 0.1% glycerol (5:5:4) and HPMC (2%) showed smaller vesicle size, high entrapment efficiency. The niosomal formation after hydration and their surface morphology of optimized formulation was studied by Motic and transmission electron microscopy. FTIR and differential scanning calorimetry studies were performed to unravel and understand the solid state properties of the drug and chemical interaction with formulation excipients. The ex-vivo Franzdiffusion studies were carried out in pH 6.8 using rat skin and the results showed better permeability of niosomes with good steady state flux and enhancement ratio suggesting the potential of proniosomal carriers for improved transdermal delivery of nifedipine. Skin irritation studies for 7 days, showed that the drug when formulated as proniosomes to be non-irritant with no erythemia development compared to pure drug. From the bio-distribution studies, the vesicles prepared with hydroxy propyl methyl cellulose with span-40 was found to be ideal batch as the concentration of drug at target site was higher.

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“…It was developed by Box and Wilson using RSM 17. It is the most commonly used optimization method with the multi-advantages of fewer test, high precision and predictability.…”

Section: Methodsmentioning

confidence: 99%

Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro

Wang¹,

Luo²,

Li³

et al. 2017

DDDT

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Invasion and metastasis are the main causes leading to the death of patients with hepatocellular carcinoma (HCC). Multivesicular liposomes loaded with oleanolic acid (OA-MVLs) have been well demonstrated to suppress survival, growth and angiogenesis of HCC cells. Emerging evidence demonstrates that OA was able to suppress the invasion of HCC cells by down-regulating myocyte enhancer factor-2. We hypothesized that the optimized OA-MVLs could inhibit the migration and invasion of HCC cells. In this study, we utilized central composite design and response surface methodology to assess the influence of some parameters on particle size and encapsulation efficiency and obtain the optimized formulation of OA-MVLs. Subsequently, the human HCC cell lines SMMC-7721 and HepG2 were treated with different doses of OA-MVLs and OA, respectively. Cellular survival, adhesion, migration and invasion in vitro were evaluated. We found that the optimized OA-MVLs significantly decreased the ability of HCC cells to adhere, migrate and invade in vitro. Furthermore, OA-MVLs significantly inhibited the survival of HCC cells at 160 µmol/L but showed no obvious inhibition effect on the cell vitality of normal liver cells. Our findings indicate that OA-MVLs did inhibit the cell survival, adhesion, invasion and metastasis of HCC cells in vitro. Although the involved mechanisms are still unclear, our findings can contribute to a better development of a preventive and therapeutic strategy for human HCC.

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Optimization of artemether-loaded NLC for intranasal delivery using central composite design

Cited by 126 publications

References 59 publications

Ziprasidone Hydrochloride Loaded Nanostructured Lipid Carriers (Nlcs) for Intranasal Delivery: Optimization and in Vivo Studies

Ziprasidone Hydrochloride Loaded Nanostructured Lipid Carriers (Nlcs) for Intranasal Delivery: Optimization and in Vivo Studies

A novel vesicular transdermal delivery of nifedipine – preparation, characterization andin vitro/in-vivoevaluation

Optimized formulation of multivesicular liposomes loaded with oleanolic acid enhanced anticancer effect in vitro

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