Modulation of Craving Related Brain Responses Using Real-Time fMRI in Patients with Alcohol Use Disorder

Karch, Susanne; Keeser, Daniel; Hümmer, Sebastian; Paolini, Marco; Kirsch, V.; Karali, Temmuz; Kupka, M.; Rauchmann, Boris‐Stephan; Chrobok, Agnieszka; Blautzik, Janusch; Koller, Gabi; Ertl‐Wagner, Birgit; Pogarell, Oliver

doi:10.1371/journal.pone.0133034

Cited by 83 publications

(79 citation statements)

References 50 publications

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“…Compared to both no feedback and sham feedback control groups, the real feedback group had reduced activation of VS after treatment. These results were similar to those reported by Karch et al (2015), who utilized two different control groups, one with false feedback and another with no feedback. The real feedback group exhibited lower activation in ACC, dlPFC, inferior temporal gyrus, MFG, and insula.…”

Section: Neuromodulatory Techniques For Treatmentsupporting

confidence: 89%

Neuroimaging the Effectiveness of Substance Use Disorder Treatments

Cabrera

Wiers

Lindgren

et al. 2016

J Neuroimmune Pharmacol

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Neuroimaging techniques to measure the function and biochemistry of the human brain such as positron emission tomography (PET), proton magnetic resonance spectroscopy ((1)H MRS), and functional magnetic resonance imaging (fMRI), are powerful tools for assessing neurobiological mechanisms underlying the response to treatments in substance use disorders. Here, we review the neuroimaging literature on pharmacological and behavioral treatment in substance use disorder. We focus on neural effects of medications that reduce craving (e.g., naltrexone, bupropion hydrochloride, baclofen, methadone, varenicline) and that improve cognitive control (e.g., modafinil, N-acetylcysteine), of behavioral treatments for substance use disorders (e.g., cognitive bias modification training, virtual reality, motivational interventions) and neuromodulatory interventions such as neurofeedback and transcranial magnetic stimulation. A consistent finding for the effectiveness of therapeutic interventions identifies the improvement of executive control networks and the dampening of limbic activation, highlighting their values as targets for therapeutic interventions in substance use disorders.

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Section: Neuromodulatory Techniques For Treatmentsupporting

confidence: 89%

Neuroimaging the Effectiveness of Substance Use Disorder Treatments

Cabrera

Wiers

Lindgren

et al. 2016

J Neuroimmune Pharmacol

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“…with alcohol use disorder, enhanced prefrontal activation after neuro-feedback-training was associated with reduced craving [Karch et al, 2015]. Interestingly, excitatory stimulation of the PFC with transcranial direct current stimulation [Kekic et al, 2014] and transcranial magnetic stimulation [Uher et al, 2005] also reduced food craving and improved the self-reported ability to resist food in healthy women.…”

Section: Discussionmentioning

confidence: 98%

Oxytocin enhances cognitive control of food craving in women

Striepens

Schroter

Stoffel‐Wagner

et al. 2016

Human Brain Mapping

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In developed countries, obesity has become an epidemic resulting in enormous health care costs for society and serious medical complications for individuals. The homeostatic regulation of food intake is critically dependent on top-down control of reward-driven food craving. There is accumulating evidence from animal studies that the neuropeptide oxytocin (OXT) is involved in regulating hunger states and eating behavior, but whether OXT also contributes to cognitive control of food craving in humans is still unclear. We conducted a counter-balanced, double-blind, within-subject, pharmacological magnetic resonance imaging experiment involving 31 healthy women who received 24 IU of intranasal OXT or placebo and were scanned twice while they were exposed to pictures of palatable food. The participants were instructed either to imagine the immediate consumption or to cognitively control the urge to eat the food. Our results show a trend that OXT specifically reduced food craving in the cognitive control condition. On the neural level, these findings were paralleled by an increase of activity in the middle and superior frontal gyrus, precuneus, and cingulate cortex under OXT. Interestingly, the behavioral OXT effect correlated with the OXT-induced changes in the prefrontal cortex and precuneus. Collectively, the present study provides first evidence that OXT plays a key role in the cognitive regulation of food craving in women by strengthening activity in a broad neurocircuitry implicated in top-down control and self-referential processing. Hum Brain Mapp 37:4276-4285, 2016. © 2016 Wiley Periodicals, Inc.

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“…To date, several studies show that neurofeedback training causes behavioral effects that are specific to the functional role of the targeted cortical area (Weiskopf et al, 2004; Bray et al, 2007; Caria et al, 2007; Rota et al, 2009; Shibata et al, 2011; Scharnowski et al, 2012, 2015; Robineau et al, 2014; Koush et al, 2015; Scharnowski and Weiskopf, 2015). Even more importantly, real-time fMRI neurofeedback training has also been shown to have therapeutic effects in chronic pain patients (deCharms et al, 2005; Guan et al, 2015), Parkinson’s disease (Subramanian et al, 2011), tinnitus (Haller et al, 2010), depression (Linden et al, 2012; Young et al, 2014), obsessive-compulsive disorder (Scheinost et al, 2013, 2014), spider phobia (Zilverstand et al, 2015), and addiction (Li et al, 2013; Karch et al, 2015; Kirsch et al, 2015; Hartwell et al, 2016). Especially for clinical applications of neurofeedback it is crucial that the learning effects persist beyond the initial training period and that voluntary control transfers to situations without neurofeedback information.…”

Section: Discussionmentioning

confidence: 99%

Maintenance of Voluntary Self-regulation Learned through Real-Time fMRI Neurofeedback

Robineau¹,

Meskaldji

Koush

et al. 2017

Front. Hum. Neurosci.

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Neurofeedback based on real-time functional magnetic resonance imaging (fMRI) is an emerging technique that allows for learning voluntary control over brain activity. Such brain training has been shown to cause specific behavioral or cognitive enhancements, and even therapeutic effects in neurological and psychiatric patient populations. However, for clinical applications it is important to know if learned self-regulation can be maintained over longer periods of time and whether it transfers to situations without neurofeedback. Here, we present preliminary results from five healthy participants who successfully learned to control their visual cortex activity and who we re-scanned 6 and 14 months after the initial neurofeedback training to perform learned self-regulation. We found that participants achieved levels of self-regulation that were similar to those achieved at the end of the successful initial training, and this without further neurofeedback information. Our results demonstrate that learned self-regulation can be maintained over longer periods of time and causes lasting transfer effects. They thus support the notion that neurofeedback is a promising therapeutic approach whose effects can last far beyond the actual training period.

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Modulation of Craving Related Brain Responses Using Real-Time fMRI in Patients with Alcohol Use Disorder

Cited by 83 publications

References 50 publications

Neuroimaging the Effectiveness of Substance Use Disorder Treatments

Neuroimaging the Effectiveness of Substance Use Disorder Treatments

Oxytocin enhances cognitive control of food craving in women

Maintenance of Voluntary Self-regulation Learned through Real-Time fMRI Neurofeedback

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