1998
DOI: 10.1016/s0079-6603(08)60509-7
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Modulation of DNA Damage and DNA Repair in Chromatin

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Cited by 115 publications
(106 citation statements)
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References 123 publications
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“…Nucleosomal DNA with an inward rotational setting is likely protected from UV damage as a result of constraints on DNA bending and flexibility imposed by the nucleosome structure (22). Formation of CPDs in DNA depends not only on the absorption of UV photons, but also the flexibility and bending of adjacent pyrimidine bases to allow the photo-induced [2 + 2] cycloaddition reaction to occur (26,27). At inward rotational settings in the nucleosome, the decrease of DNA flexibility and compression of the minor groove is likely responsible for suppressing CPD formation at such sites (27).…”
Section: Discussionmentioning
confidence: 99%
“…Nucleosomal DNA with an inward rotational setting is likely protected from UV damage as a result of constraints on DNA bending and flexibility imposed by the nucleosome structure (22). Formation of CPDs in DNA depends not only on the absorption of UV photons, but also the flexibility and bending of adjacent pyrimidine bases to allow the photo-induced [2 + 2] cycloaddition reaction to occur (26,27). At inward rotational settings in the nucleosome, the decrease of DNA flexibility and compression of the minor groove is likely responsible for suppressing CPD formation at such sites (27).…”
Section: Discussionmentioning
confidence: 99%
“…Because chromatin rearrangements occur during DNA repair (53,54), the accessibility of EcoRI to rDNA chromatin was followed during NER (Figs. 5 and 6).…”
Section: Discussionmentioning
confidence: 99%
“…Changes in chromatin structure are known to go along with NER and are required for efficient DNA repair in the context of condensed chromatin [79,80]. Recent studies in yeast revealed an enhanced association of subunits of the SWI/SNF chromatin-remodelling complex with Rad4-Rad23 (XPC-RAD23B in human), the principal DNA damage recognition factor in GG-NER [81].…”
Section: Recruitment Of Chromatin Remodellers In Tc-nermentioning
confidence: 99%