Modulation of dopamine metabolizing enzymes and antioxidant status by Capsicum annuum Lin in rotenone-intoxicated rat brain

Abstract

Graphical abstract

Ninety-day repeated oral toxicity study of saponified Capsicum annum fruit extract with 50% capsanthin in Sprague-Dawley Rats with a 28-day recovery period

“…Administration of corn oil at the usual dose rate of 10 mL/kg as a vehicle of a test agent to rats resulted in toxic effects on the kidney. Histopathologic findings of corn oil 10 mL/kg fed male rats showed severe epithelial necrosis and fatty degeneration of the proximal tubule and female rats showed severe fatty degeneration of proximal tubules tended to have both necrosis and basophilic tubules [27] . In this study, the tubular degenerative changes in both control and treated group may be attributed to corn oil treatment.…”

Cognitive impairment by non‐insulin‐dependent diabetes mellitus was attenuated by dietary supplements of marble vine (Dioclea reflexa) and plantain (Musa paradisiaca) dough meals in albino rats

“…Redox abnormalities in favor of cerebral oxidative reactions result in oxidative damage and subsequent damage to neuronal cell membrane or mitochondria (Valko et al, 2007;Funk, Yurdagul, & Orr, 2012). The increase in the dopamine concentration by the formulated dough meals sample suggests their ability to enhance tyrosine hydroxylase activity for increased dopamine synthesis (Ogunruku, Ogunyemi, Oboh, Babatunde, & Boligon, 2019. Although, dopamine is an enzyme that plays vital role in the motor functions, a reduction in its concentration leads to significant degradation in the activities of the motor neurons which is seen in patients suffering from stroke and its related complications (Gallego, Setién, Izquierdo, Casis, & Casis, 2003).…”

Neuroprotective effects of curcumin on the cerebellum in a rotenone‐induced Parkinson’s Disease Model

“…Moreover, selective loss of dopamine neurons and low striatum dopamine levels occur in PD patients. Dopamine deficiency eventually causes dysregulation of basal ganglia circuits, resulting in clinical motive symptoms, including bradykinesia, restless tremor, rigidity, and postural instability 3 . Recently, the role of oxidative stress has attracted increasing attention in neurological abnormalities.…”

“…Dopamine deficiency eventually causes dysregulation of basal ganglia circuits, resulting in clinical motive symptoms, including bradykinesia, restless tremor, rigidity, and postural instability. 3 Recently, the role of oxidative stress has attracted increasing attention in neurological abnormalities. Therefore, oxidative stress may also play a role in PD pathophysiology.…”

“…tween the four groups [F(3,36) = 166.6, p < 0.0001]. Tukey's post hoc test revealed that GSH levels in group II (22.64 ± 4.08) were significantly lower than those in groups I (112.14 ± 4.03, p < 0.0001), III (120.47 ± 1.91, p < 0.0001), and IV (120.47 ± 1.91, p < 0.0001) as shown in Figure12F.…”