Neuroprotective effects of curcumin on the cerebellum in a rotenone‐induced Parkinson’s Disease Model

Fikry, Heba; Saleh, Lobna A.; Gawad, Sara Abdel

doi:10.1111/cns.13805

Cited by 39 publications

(16 citation statements)

References 55 publications

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“…Curcumin is found to be effective in in vivo models of AD and PD at doses 30-80 mg/kg i.p. and 150-300 mg/kg oral gavage per day treatment (Fikry et al, 2022;Rajeswari & Sabesan, 2008;Sharma & Nehru, 2018;Zheng et al, 2017). Also, in clinical trials of AD and PD patients, curcumin is reported to be used at doses from 0.08 to 4 g daily by oral administration (Ghodsi et (Maiti et al, 2021;Tello-Franco et al, 2013;Wu et al, 2022).…”

Section: Plant-derived Polyphenolsmentioning

confidence: 99%

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Phukan,

Roy,

Gahatraj

et al. 2023

Phytotherapy Research

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Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by the impairment of memory and motor functions, respectively. Despite several breakthroughs, there exists a lack of disease‐modifying treatment strategies for these diseases, as the available drugs provide symptomatic relief and bring along side effects. Bioactive compounds are reported to bear neuroprotective properties with minimal toxicity, however, a detailed elucidation of their modes of neuroprotection is lacking. The review elucidates the neuroprotective mechanism(s) of some of the major phyto‐compounds in pre‐clinical and clinical studies of AD and PD to understand their potential in combating these diseases. Curcumin, eugenol, resveratrol, baicalein, sesamol and so on have proved efficient in countering the pathological hallmarks of AD and PD. Curcumin, resveratrol, caffeine and so on have reached the clinical phases of these diseases, while aromadendrin, delphinidin, cyanidin and xanthohumol are yet to be extensively explored in pre‐clinical phases. The review highlights the need for extensive investigation of these compounds in the clinical stages of these diseases so as to utilize their disease‐modifying abilities in the real field of treatment. Moreover, poor pharmacokinetic properties of natural compounds are constraints to their therapeutic yields and this review suggests a plausible contribution of nanotechnology in overcoming these limitations.

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Section: Plant-derived Polyphenolsmentioning

confidence: 99%

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Phukan,

Roy,

Gahatraj

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…It is known for its potent neuroprotective, anti-inflammatory, antioxidant, and anticancer properties. [7][8][9][10][11] Several studies have demonstrated that curcumin plays a protective role in several neurodegenerative diseases, including Parkinson's disease, [12] Alzheimer's disease, [13] and Huntington's disease, [14] as well as neuroinflammation. [15] Many studies have described the anti-inflammatory effects of curcumin in nervous system disorders, chronic inflammation, cancer, cardiovascular disease, and other common diseases.…”

Section: Backgroundsmentioning

confidence: 99%

Curcumin protects PC12 cells from a high glucose-induced inflammatory response by regulating the miR-218-5p/TLR4 axis

Yuan

Song²,

Zhang³

et al. 2022

Medicine

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Background: Curcumin exerts a protective effect on diabetic encephalopathy (DN), It is known for its potent neuroprotective, anti-inflammatory, antioxidant, and anticancer properties. However, the underlying mechanisms of curcumin's neuroprotective effects resulting from high glucose (HG)-induced injuries remain unknown. The purpose of this study is to identify the protective mechanism of Curcumin in the DN.Methods: In this study, pheochromocytoma cells (PC12 cells) were pretreated with different concentrations of Curcumin and then co-treated with Curcumin and glucose for 48 hours, and the cell viability was evaluated by CCK-8, the expression of the inflammatory mediators were detected by ELISA, the miR-218-5p and toll-like receptors (TLR4) level were examined by both quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, the potential target genes of miR-218-5p were identified using luciferase reporter assay.Results: The viability of PC12 cells treated with HG was significantly reduced in a dose-and time-dependent manner. Cotreatment of curcumin with HG significantly increased cell viability. Curcumin inhibited the expression of the inflammatory mediators, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), and induced the expression of the anti-inflammatory mediator interleukin-10 (IL-10). Curcumin upregulated the levels of miR-218-5p and downregulated the expression of TLR4 in HG-treated PC12 cells. The curcumin-induced anti-inflammatory effect was abrogated by a miR-218-5p inhibitor and overexpression of TLR4. The results suggest that curcumin ameliorates the inflammatory response by upregulating miR-218-5p levels in PC12 cells. Conclusions: Our results indicate a protective role for curcumin in PC12 cells and suggest that it should be considered for the prophylactic treatment of DN in the future. Abbreviations: 3'UTR = 3'-untranslated region, DMEM = Dulbecco's modified eagle medium, DN = diabetic encephalopathy, FBS = fetal bovine serum, HG = high glucose, IL-10 = interleukin-10, IL-6 = interleukin 6, miRNAs = microRNAs, PC12 cells = pheochromocytoma cells, qRT-PCR = quantitative real-time polymerase chain reaction, TBST = tris buffered saline with tween-20, TLR = Toll-like receptors, TNF-α = tumor necrosis factor-α.

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“…The cerebellum is a brain region important for motor and non-motor functions [1][2][3][4][5]. It has been shown that abnormalities in the cerebellum are associated with several diseases such as cerebellar hypoplasia, ataxia, autism and Parkinson's disease (PD) [6][7][8]. The cerebellum originates from the anterior hindbrain [9].…”

Section: Introductionmentioning

confidence: 99%

Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

Cheng

Xia

et al. 2023

Mol Brain

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The prenylation of proteins is involved in a variety of biological functions. However, it remains unknown whether it plays an important role in the morphogenesis of the cerebellum. To address this question, we generated a mouse model, in which the geranylgeranyl pyrophosphate synthase (Ggps1) gene is inactivated in neural progenitor cells in the developing cerebellum. We report that conditional knockout (cKO) of Ggps1 leads to severe ataxia and deficient locomotion. To identify the underlying mechanisms, we completed a series of cellular and molecular experiments. First, our morphological analysis revealed significantly decreased population of granule cell progenitors (GCPs) and impaired proliferation of GCPs in the developing cerebellum of Ggps1 cKO mice. Second, our molecular analysis showed increased expression of p21, an important cell cycle regulator in Ggps1 cKO mice. Together, this study highlights a critical role of Ggpps-dependent protein prenylation in the proliferation of cerebellar GCPs during cerebellar development.

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Neuroprotective effects of curcumin on the cerebellum in a rotenone‐induced Parkinson’s Disease Model

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 39 publications

References 55 publications

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Curcumin protects PC12 cells from a high glucose-induced inflammatory response by regulating the miR-218-5p/TLR4 axis

Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

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