1986
DOI: 10.1073/pnas.83.21.8226
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Modulation of epidermal growth factor receptors by human alpha interferon.

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Cited by 50 publications
(19 citation statements)
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“…Our data on EGFR numbers in these variants of the ZR-75-1 line contrast with an earlier report from this laboratory which showed no significant changes in expression of receptors for Interferon a 2c (Martin et al, 1991 (Zoon et al, 1986;Hamburger & Pinnamaneni, 1991).…”
Section: Resultscontrasting
confidence: 56%
“…Our data on EGFR numbers in these variants of the ZR-75-1 line contrast with an earlier report from this laboratory which showed no significant changes in expression of receptors for Interferon a 2c (Martin et al, 1991 (Zoon et al, 1986;Hamburger & Pinnamaneni, 1991).…”
Section: Resultscontrasting
confidence: 56%
“…A very attractive hypothesis would be that HLA class I molecules are in close association with NK or LAK target structures. This hypothesis is substantiated by a number of reports which indicated that several molecules are associated with HLA class I at the cell surface, including the insulin receptor (Chvatchko et al, 1983), the IL-2 receptor (Szollosi et al, 1987) and the EGF receptor (Schreiber et al, 1984), and are modulated by IFN-y (Pfeffer et al, 1987;Zoon et al, 1986).…”
Section: Discussionmentioning
confidence: 67%
“…Downregulation of expression of speci®c genes by IFNs may also negatively regulate growth (Pestka et al, 1987). This possibility is suggested by several lines of evidence: (1) IFNs down-regulate expression of growth factor receptors thereby antagonizing the growth promoting eects of speci®c growth factors (Zoon et al, 1986); (2) IFNs inhibit the activity of ornithine decarboxylase which is a rate-limiting enzyme in the biosynthesis of polyamines (Sreevalsan et al, 1980;Sekar et al, 1983); and (3) IFNs inhibit genes involved in cell growth (Harel-Bellam et al, 1988;Chatterjee and Savarese, 1992). These results suggest that multiple mechanisms may underlie the ability of IFNs to inhibit cell growth.…”
Section: Introductionmentioning
confidence: 98%