Modulation of gastrointestinal bacterial in chronic atrophic gastritis model rats by Chinese and west medicine intervention

Abstract

Chronic atrophic gastritis (CAG) is well-known related with multiple pathogenic factors and normally therapies comprised by western or Chinese medicines. The present study was designed to identify the bacterial community characterized by 16S rRNA amplicon sequencing and determine the modulate affection of bacterial composition response western and Chinese medicine Qinghuayin (QHY) as well as antibiotic on model rats. The result shown the overall structure alteration of bacterial appeared under medicine intervened, antibiotic caused a marked depletion in bacterial diversity and richness. The enrichments of Firmicutes (85.1–90.7%) in antibiotic-free converts into Bacteroidetes (30.7–34.6%) in antibiotic-added model rat were demonstrated. Firmicutes as the most dominant phylum in antibiotic-free treatments and significantly decreased till 21.9–68.5% in antibiotic-added treatments. Especially QHY-treated rats showed highest RA of Firmicutes (90.7%) and the amelioration of CAG using QHY attributed by beneficial bacterial enrichment, especially Ruminococcus, Lactobacillus and Bifidobacterium. In addition, alpha and beta diversity analysis also demonstrated the clear dispersion and aggregation that revealed the alteration and steady of bacterial community structures. In summary, QHY has potential application value in the treatment of CAG, which attributed to close relation with the modulatory of internal bacterial communities.

Exploring the therapeutic mechanisms of Coptidis Rhizoma in gastric precancerous lesions: a network pharmacology approach

“…However, due to its inherently “cold” nature according to Traditional Chinese Medicine theory, prolonged use may lead to gastrointestinal discomfort [ 28 , 29 ]. It is also the mainstay of many Chinese herbal compounds for the treatment of GPL, such as Huazhuojiedu decoction, Qinhuayin, and Weixibaonizhuan pills [ 27 , 30 , 31 ]. In vitro experiments have demonstrated that the main extracts of Coptidis Rhizoma, such as berberine and quercetin, have antitumor activities, such as inhibiting angiogenesis and inducing apoptosis [ 32 – 34 ].…”

High Hepcidin Levels Promote Abnormal Iron Metabolism and Ferroptosis in Chronic Atrophic Gastritis

“…A growing number of studies have focused primarily on the impact of Helicobacter pylori infection on hepcidin levels in the intestinal tract [ 2 , 4 , 31 ]. This infection is known to be a significant risk factor for the development of CAG and GC, leading to anemia and depletion of serum iron stores, inducing anemia and depleting serum iron storage levels [ 32 , 33 ].…”

Granule Dendrobii suppresses chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine by modulating the gastrointestinal bacteria in rats

“…Traditional Chinese medicine (TCM) has a unique advantage in treating gastrointestinal diseases with reliable therapeutic efficacy and fewer adverse effects. Studies have shown that TCM can reduce or reverse the precancerous lesions of GC, and prevent the development of GC (7)(8). Granule Dendrobii (GD), a TCM herb composed of Dendrobium officinale Kimura et Migo and Panax quinquefolium L, is commonly used for treating stomach diseases.…”