Modulation of GdCl<sub>3</sub>and Angelica Sinensis polysaccharides on differentially expressed genes in liver of hepatic immunological injury mice by cDNA microarray

Ding, Hong; Shi, Gang-Gang; Yu, Xin; Yu, Jin; Huang, Jiean

doi:10.3748/wjg.v9.i5.1072

Cited by 7 publications

(2 citation statements)

References 36 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunoactivity is the most important function of ASP. It could enhance the proliferative response of lymphocytes in vitro and differential expression of genes in the liver of immunological injury mice [27,28] . In the present study, 30 mg/kg ASP could increase cytochrome P450 content , P450 isoform activities and GST activities.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Kupffer cells on hepatic drug metabolism

Ding¹,

Tong²,

Wu³

et al. 2004

WJG

Self Cite

View full text Add to dashboard Cite

AIM:To observe the effects of Kupffer cells on hepatic drug metabolic enzymes. METHODS:Kunming mice were ip injected with GdCl 3 10, 20, 40 mg/kg to decrease the number and block the function of kupffer cells selectively. The contents of drug metabolic enzymes, cytochrome P450, NADPH-cytochrom C redutase (NADPH-C), aniline hydroxylase (ANH), aminopyrine Ndemethylase (AMD), erythromycin N-demethylase (EMD), and glutathione s-transferase (mGST) in hepatic microsome and S9-GSTpi, S9-GST in supernatant of 9 000 g were accessed 1 d after the injection. The time course of alteration of drug metabolic enzymes was observed on d 1, 3, and 6 treated with a single dose GdCl 3 . Mice were treated with Angelica sinensis polysaccharides (ASP) of 30, 60, 120 mg/kg, ig, qd ×6 d, respectively and the same assays were performed. RESULTS: P450 content and NADPH-C, ANH, AMD, and EMD activities were obviously reduced 1 d after Kupffer cell blockade. However, mGST and S9-GST activities were significantly increased. But no relationship was observed between GdCl 3 dosage and enzyme activities. With single dose GdCl 3 treatment, P450 content, NADPH-C, and ANH activities were further decreased following Kupffer cell blockade lasted for 6 d, by 35.7%, 50.3%, 36.5% after 3 d, and 57.9%, 57.9%, 63.2% after 6 d, respectively. On the contrary, AMD, EMD, mGST, and S9-GST activities were raised by 36.5%, 71.9%, 23.1%, 35.7% after 3 d, and 155%, 182%, 21.5%, 33.7% after 6 d, respectively. Furthermore, the activities of drug metabolic enzymes were markedly increased after 30 mg/kg ASP treatment, and decreased significantly after 120 mg/kg ASP treatment. No change in activity of S9-GSTpi was observed in the present study.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulation of Kupffer cells on hepatic drug metabolism

Ding¹,

Tong²,

Wu³

et al. 2004

WJG

Self Cite

View full text Add to dashboard Cite

show abstract

“…Diels, is a potent bioactive compound known for its hepatoprotective effects. It has demonstrated efficacy in various liver disease models, including lipopolysaccharide (LPS) and Bacillus Calmette–Guerin‐induced hepatic immunological injury (Ding et al, 2003), acetaminophen‐induced acute liver injury (Cao et al, 2018), CCl 4 ‐induced liver fibrosis (Wang et al, 2020), alcoholic fatty liver disease (AFLD) (He et al, 2022), and high‐fat diet (HFD)‐induced NAFLD (Wang et al, 2016). A large number of in vivo and in vitro experiments have validated the pharmacological potential of orally administered polysaccharides (Pan et al, 2022; Zheng et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Angelica sinensis polysaccharide ameliorates nonalcoholic fatty liver disease via restoring estrogen‐related receptor α expression in liver

Luo

Zhang

Chen

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Angelica sinensis polysaccharide (ASP) showed increasingly recognized hepatoprotective effects and lipid regulation. Because polysaccharides are typically degraded into fragments or short‐chain fatty acids in the gut, rather than being absorbed in their intact form, it is worth pondering why ASP can regulate hepatic lipid metabolism and protect the liver from damage caused by lipid accumulation. In vivo and in vitro nonalcoholic fatty liver disease (NAFLD) models with lipid accumulation were established to investigate the effect and potential mechanisms of ASP on hepatic fat accumulation. Our results showed that ASP remodeled the composition and abundance of the gut microbiota in high‐fat diet‐fed mice and increased their levels of propionate (0.92 ± 0.30 × 107 vs. 2.13 ± 0.52 × 107) and butyrate (1.83 ± 1.31 × 107 vs. 6.39 ± 1.44 × 107). Sodium propionate significantly increased the expression of estrogen‐related receptor α (ERRα) in liver cells (400 mM sodium propionate for 2.19‐fold increase) and alleviated the progress of NAFLD in methionine–choline‐deficient diet model. Taken together, our study demonstrated that ASP can regulate hepatic lipid metabolism via propionate/ERRα pathway and ultimately relieving NAFLD. Our findings demonstrate that ASP can be used as a health care product or food supplement to prevent NAFLD.

show abstract

Current awareness on comparative and functional genomics

2003

Comp Funct Genom

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, this current awareness service is provided by John Wiley & Sons and contains newly‐published material on comparative and functional genomics. Each bibliography is divided into 16 sections. 1 Reviews & symposia; 2 General; 3 Large‐scale sequencing and mapping; 4 Genome evolution; 5 Comparative genomics; 6 Gene families and regulons; 7 Pharmacogenomics; 8 Large‐scale mutagenesis programmes; 9 Functional complementation; 10 Transcriptomics; 11 Proteomics; 12 Protein structural genomics; 13 Metabolomics; 14 Genomic approaches to development; 15 Technological advances; 16 Bioinformatics. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

show abstract

Modulation of GdCl₃and Angelica Sinensis polysaccharides on differentially expressed genes in liver of hepatic immunological injury mice by cDNA microarray

Abstract: AIM:To study the modulating effect of GdCl 3 and Angelica Sinensis polysaccharides (ASP) on differentially expressed genes in liver of hepatic immunological mice by cDNA microarray. METHODS:Hepatic immunological injury was induced by lipopolysaccharide (LPS ip, 0.2 mg·kg -1

Cited by 7 publications

References 36 publications

Modulation of Kupffer cells on hepatic drug metabolism

Modulation of Kupffer cells on hepatic drug metabolism

Angelica sinensis polysaccharide ameliorates nonalcoholic fatty liver disease via restoring estrogen‐related receptor α expression in liver

Current awareness on comparative and functional genomics

Contact Info

Product

Resources

About

Modulation of GdCl3and Angelica Sinensis polysaccharides on differentially expressed genes in liver of hepatic immunological injury mice by cDNA microarray

Abstract: AIM:To study the modulating effect of GdCl 3 and Angelica Sinensis polysaccharides (ASP) on differentially expressed genes in liver of hepatic immunological mice by cDNA microarray. METHODS:Hepatic immunological injury was induced by lipopolysaccharide (LPS ip, 0.2 mg·kg -1

Cited by 7 publications

References 36 publications

Modulation of Kupffer cells on hepatic drug metabolism

Modulation of Kupffer cells on hepatic drug metabolism

Angelica sinensis polysaccharide ameliorates nonalcoholic fatty liver disease via restoring estrogen‐related receptor α expression in liver

Current awareness on comparative and functional genomics

Contact Info

Product

Resources

About

Modulation of GdCl₃and Angelica Sinensis polysaccharides on differentially expressed genes in liver of hepatic immunological injury mice by cDNA microarray