2022
DOI: 10.1016/j.bpc.2022.106856
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Modulation of global stability, ligand binding and catalytic properties of trypsin by anions

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Cited by 3 publications
(3 citation statements)
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“…The observed slopes of thermodynamic parameters obtained for different salts (e.g., ΔΔH/Δ[salt]) are specific for a given chloride salt and may be correlated with some of the physicochemical properties of the cation. Similar correlations were found in different studies of proteins in the presence of salts of the Hofmeister series [ 42 , 43 , 44 , 45 ]. In our case, we could not find any evidence for a robust correlation between the salt-specific values of the slopes and ion properties such as hydration entropy, hydration number, charge density, polarizability, and viscosity B coefficient (see Figures S6–S17 , Supplementary Materials , which includes also pairwise correlations between thermodynamic parameters of domains).…”
Section: Discussionsupporting
confidence: 88%
“…The observed slopes of thermodynamic parameters obtained for different salts (e.g., ΔΔH/Δ[salt]) are specific for a given chloride salt and may be correlated with some of the physicochemical properties of the cation. Similar correlations were found in different studies of proteins in the presence of salts of the Hofmeister series [ 42 , 43 , 44 , 45 ]. In our case, we could not find any evidence for a robust correlation between the salt-specific values of the slopes and ion properties such as hydration entropy, hydration number, charge density, polarizability, and viscosity B coefficient (see Figures S6–S17 , Supplementary Materials , which includes also pairwise correlations between thermodynamic parameters of domains).…”
Section: Discussionsupporting
confidence: 88%
“…To determine whether there is a correlation between ion properties and their efficiency in affecting the rate of the eADF4(C16) fibril elongation, we plotted the slope of dk + /d[salt] from Figure 5a, within the concertation range of 0-150 mM salt, against selected intrinsic properties of the anions. Many parameters reflect different anion properties, but as we pointed out in our previous work, some of these parameters correlate with each other, significantly reducing the number of meaningful dependencies (Dušekov a et al, 2022). As a result, we plotted the parameter dk + /d[salt] versus charge density (Figure 5b) (which also correlates with surface tension and air/water partition coefficient of anions), polarizability (Figure 5d), and viscosity B-coefficient (which also correlates with partition coefficient at hydrocarbon surface) (Figure 5c).…”
Section: Morphology Of Nanofibrilsmentioning
confidence: 90%
“…In 1888, Franz Hofmeister divided ions into kosmotropes and chaotropes based on their capacity to either “fit into” or “break” the ordered structure of water, and their capability to salt out or salt in proteins, respectively (Hofmeister, 1888). By arranging selected anions according to their impact on various protein properties, such as solubility, stability, or activity (Baldwin, 1996; Cacace et al, 1997; Dušeková et al, 2022; Sedlak et al, 2008), the so‐called Hofmeister series of anions can be arranged in the following order: normalSO42>lefttrueHPO42>normalF>normalCl>normalBr>normalI>NO3>ClO4>normalSCN. …”
Section: Introductionmentioning
confidence: 99%