Modulation of human ovarian function by melatonin

Rai, Seema; Ghosh, Hindole

doi:10.2741/875

Cited by 17 publications

(10 citation statements)

References 7 publications

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“…The expression of StAR is also under the diurnal regulation of melatonin in both gonads and adrenal glands [testes ( Frungieri et al, 2017 ), ovaries ( Tamura et al, 2009 ; Rai and Gosh, 2021 ) and adrenal glands ( Minnetti et al, 2020 )].…”

Section: Circadian Regulation Of Steroidogenesismentioning

confidence: 99%

“…Melatonin also regulates the mRNA level of the enzymes important in ovarian androgen and estrogen synthesis. In porcine antral follicles, melatonin inhibited expression of CYP 17A1 but not CYP19A1 (reviewed by Tamura et al, 2009 ; Rai and Gosh, 2021 ). Pinealectomy increased CYP17A1 in rat theca interna and interstitial cells and CYP19A1 in granulosa cells whereas chronic administration of melatonin decreased CYP17A1 ( Maganhin et al, 2014 ; Lima et al, 2015 ).…”

Section: Circadian Regulation Of Steroidogenesismentioning

confidence: 99%

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Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids

Yao

Silver

2022

Front. Behav. Neurosci.

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BackgroundSteroids are lipid hormones that reach bodily tissues through the systemic circulation, and play a major role in reproduction, metabolism, and homeostasis. All of these functions and steroids themselves are under the regulation of the circadian timing system (CTS) and its cellular/molecular underpinnings. In health, cells throughout the body coordinate their daily activities to optimize responses to signals from the CTS and steroids. Misalignment of responses to these signals produces dysfunction and underlies many pathologies.Questions AddressedTo explore relationships between the CTS and circulating steroids, we examine the brain clock located in the suprachiasmatic nucleus (SCN), the daily fluctuations in plasma steroids, the mechanisms producing regularly recurring fluctuations, and the actions of steroids on their receptors within the SCN. The goal is to understand the relationship between temporal control of steroid secretion and how rhythmic changes in steroids impact the SCN, which in turn modulate behavior and physiology.Evidence SurveyedThe CTS is a multi-level organization producing recurrent feedback loops that operate on several time scales. We review the evidence showing that the CTS modulates the timing of secretions from the level of the hypothalamus to the steroidogenic gonadal and adrenal glands, and at specific sites within steroidogenic pathways. The SCN determines the timing of steroid hormones that then act on their cognate receptors within the brain clock. In addition, some compartments of the body-wide CTS are impacted by signals derived from food, stress, exercise etc. These in turn act on steroidogenesis to either align or misalign CTS oscillators. Finally this review provides a comprehensive exploration of the broad contribution of steroid receptors in the SCN and how these receptors in turn impact peripheral responses.ConclusionThe hypothesis emerging from the recognition of steroid receptors in the SCN is that mutual shaping of responses occurs between the brain clock and fluctuating plasma steroid levels.

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Section: Circadian Regulation Of Steroidogenesismentioning

confidence: 99%

Section: Circadian Regulation Of Steroidogenesismentioning

confidence: 99%

Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids

Yao

Silver

2022

Front. Behav. Neurosci.

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“…What's more, MT can act on the hypothalamic-pituitary-ovarian axis (HPO) via hypothalamic gonadotropins or directly bind to ovarian granulosa cells to exert effects on HPO [ 55 ]. Additionally, MT plays a central role in the reproductive system by upregulating LH receptor mRNA to suppress gonadotropin-releasing hormone (GnRH) and GnRH receptor expression as well [ 56 ]. As for the resource, MT in the ovary can be derived from systemic blood circulation or synthesized by granulosa cells, including the cumulus granulosa cells and oocytes [ 57 – 60 ].…”

Section: There Is a Strong Connection Between Melatonin (Mt) And Poimentioning

confidence: 99%

Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved

Sun

Yang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Objective. Premature ovarian insufficiency (POI) is a female reproductive disorder of unknown etiology with no definite pathogenesis. Melatonin (MT) is an endogenous hormone synthesized mainly by pineal cells and has strong endogenous effects in regulating ovarian function. To systematically explore the pharmacological mechanism of MT on POI therapy, a literature review approach was conducted at the signaling pathways level. Methods. Relevant literatures were searched and downloaded from databases, including PubMed and China National Knowledge Infrastructure, using the keywords “premature ovarian insufficiency,” “Hippo signaling pathways,” and “melatonin.” The search criteria were from 2010 to 2022. Text mining was also performed. Results. MT is involved in the regulation of Hippo signaling pathway in a variety of modes and has been correlated with ovarian function. Conclusions. The purpose of this review is to summarize the research progress of Hippo signaling pathways and significance of MT in POI, the potential crosstalk between MT and Hippo signaling pathways, and the prospective therapy.

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“…MT can act on the hypothalamus-pituitary-ovarian axis (HPO) by regulating the hypothalamic gonadotropins, which can also directly bind to the ovarian granulosa cells to exert effects on HPO [ 26 , 27 ]. MT inhibits the expressions of gonadotropin-releasing hormone (GnRH) and GnRH receptors by up-regulating the LH receptor mRNAs [ 28 ]. GnRH, in turn, controls the secretions of the gonadotropin luteinizing hormone (LH) and follicle stimulating hormone (FSH), which regulates the reproductive function at the gonadal level and participates in maintaining the level of the corpus luteum during pregnancy [ 28 , 29 ].…”

Section: Mt and Ovarian Functionsmentioning

confidence: 99%

“…MT inhibits the expressions of gonadotropin-releasing hormone (GnRH) and GnRH receptors by up-regulating the LH receptor mRNAs [ 28 ]. GnRH, in turn, controls the secretions of the gonadotropin luteinizing hormone (LH) and follicle stimulating hormone (FSH), which regulates the reproductive function at the gonadal level and participates in maintaining the level of the corpus luteum during pregnancy [ 28 , 29 ]. The wide distribution of MT receptors is the basis for its extensive biological effects.…”

Section: Mt and Ovarian Functionsmentioning

confidence: 99%

Research progress of melatonin (MT) in improving ovarian function: a review of the current status

Guo

Sun

Wang

et al. 2021

Aging

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Melatonin (MT) is an endogenous hormone mainly synthesized by pineal cells, which has strong endogenous effects of eliminating free radicals and resisting oxidative damages. Melatonin (MT) can not only regulate the body’s seasonal and circadian rhythms; but also delay ovarian senescence, regulate ovarian biological rhythm, promote follicles formation, and improve oocyte quality and fertilization rate. This review aimd to provide evidence concerning the synthesis and distribution, ovarian function, and role of MT in development of follicles and oocytes. Moreover, the role of MT as antioxidative, participating in biological rhythm regulation, was also reviewed. Furthermore, the effects of MT on various ovarian related diseases were analyzed, particularly for the ovarian aging and polycystic ovary syndrome (PCOS).

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Modulation of human ovarian function by melatonin

Cited by 17 publications

References 7 publications

Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids

Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids

Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved

Research progress of melatonin (MT) in improving ovarian function: a review of the current status

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