Modulation of immune function and cytokine production by various levels of vitamin E supplementation during murine AIDS

Wang, Yuejian; Huanga, Dennis S.; Wood, Steve; Watson, Ronald R.

doi:10.1016/0162-3109(95)00061-w

Cited by 45 publications

(22 citation statements)

References 26 publications

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“…Dietary supplementation with vit. E in mice infected with LP-BM5 retrovirus, restored the inhibited IL-2 and interferon gamma production by splenocytes and normalized the increased IL-6 and IL-10 production caused by retrovirus infection [26]. Healthy adults supplemented with vit.…”

Section: Discussionmentioning

confidence: 99%

In vitro immune response of human peripheral blood cells to vitamins C and E

Bergman

Salman

Djaldetti

et al. 2004

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 99%

In vitro immune response of human peripheral blood cells to vitamins C and E

Bergman

Salman

Djaldetti

et al. 2004

The Journal of Nutritional Biochemistry

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“…Vitamin C helps improve T- and B-lymphocyte proliferative responses and reduces the concentration of proinflammatory cytokines [39-41]. Vitamin E is responsible for improving delayed type hypersensitivity skin response, increasing IL-2 production, neutrophil phagocytosis, lymphocyte proliferation, and antibody response to T-cell dependent vaccines, and reducing production of inflammatory cytokines such as TNF- α and IL-6 [42,43]. However, we did not observe an association between immune markers such as CD4, CD8, and CD3 T-cell count with multivitamin supplementation, except for children older than 3 years of age.…”

Section: Discussionmentioning

confidence: 99%

A randomized trial of multivitamin supplementation in children with tuberculosis in Tanzania

Mehta

Mugusi²,

Bosch

et al. 2011

Nutr J

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BackgroundChildren with tuberculosis often have underlying nutritional deficiencies. Multivitamin supplementation has been proposed as a means to enhance the health of these children; however, the efficacy of such an intervention has not been examined adequately.Methods255 children, aged six weeks to five years, with tuberculosis were randomized to receive either a daily multivitamin supplement or a placebo in the first eight weeks of anti-tuberculous therapy in Tanzania. This was only 64% of the proposed sample size as the trial had to be terminated prematurely due to funding constraints. They were followed up for the duration of supplementation through clinic and home visits to assess anthropometric indices and laboratory parameters, including hemoglobin and albumin.ResultsThere was no significant effect of multivitamin supplementation on the primary endpoint of the trial: weight gain after eight weeks. However, significant differences in weight gain were observed among children aged six weeks to six months in subgroup analyses (n = 22; 1.08 kg, compared to 0.46 kg in the placebo group; 95% CI = 0.12, 1.10; p = 0.01). Supplementation resulted in significant improvement in hemoglobin levels at the end of follow-up in children of all age groups; the median increase in children receiving multivitamins was 1.0 g/dL, compared to 0.4 g/dL in children receiving placebo (p < 0.01). HIV-infected children between six months and three years of age had a significantly higher gain in height if they received multivitamins (n = 48; 2 cm, compared to 1 cm in the placebo group; 95% CI = 0.20, 1.70; p = 0.01; p for interaction by age group = 0.01).ConclusionsMultivitamin supplementation for a short duration of eight weeks improved the hematological profile of children with tuberculosis, though it didn't have any effect on weight gain, the primary outcome of the trial. Larger studies with a longer period of supplementation are needed to confirm these findings and assess the effect of multivitamins on clinical outcomes including treatment success and growth failure.Clinicaltrials.gov IdentifierNCT00145184

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“…Higher level of ␣-tocopherol may promote the transport of ␣-tocopherol to the uterus and placenta during embryogenesis, which may compensate for vitamin E loss caused by infections. A previous study also reported that high-level vitamin E supplementation in infected mice could reverse immune function disorders caused by retrovirus infection as well as promoting recovery of infected mice (36). It was reported that vitamin E supplement increased the survival rate of mice infected with type I Diplococcus lanceolatus from 15 to 70% (37).…”

Section: Discussionmentioning

confidence: 99%

Effects of Vitamin E on Reproductive Protection in Pregnant Mice Infected with Pseudorabies Virus (PRV) via Regulating Expression of Toll-Like Receptors (TLRs) and Cytokine Balance

Luo

Lin

et al. 2010

J Nutr Sci Vitaminol

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Summary Vitamin E supplement and pseudorabies virus (PRV) infection have a reciprocal role in influencing the maternal immune response, a key determinant of the success or failure of pregnancy. However, it remains unknown whether vitamin E supplement provides protection against PRV-induced failure of pregnancy. This study was therefore conducted to investigate the effect of dietary vitamin E level (0, 75, 375, 750 and 1,500 mg/kg) on the reproduction performance, immunity and expression of Toll-like receptors (TLRs) of PRVchallenged mice. The mortality and abortion rate of PRV-challenged mice decreased with the increase in vitamin E consumption. Overall, PBS-injected mice had a higher live embryo number and live litter size than PRV-challenged mice. Both live embryo number and live litter size of PRV-challenged mice increased with increasing vitamin E levels. Vitamin E supplement resulted in decreased concentration of serum IL-2 and IFN-␥ , but increased concentration of serum IL-10. The concentration of serum IgG, IgA and IgM increased with increasing vitamin E levels. In the uterine and embryo mRNA abundance of TLR3, TLR7 and TLR9 was higher in PRV-challenged mice than that in PBS-injected mice fed on the same dosage of vitamin E. The mRNA abundance of embryonic TLR3, TLR7 and TLR9 in PRV-challenged mice decreased with increasing vitamin E levels. Collectively, vitamin E supplement may improve reproductive performance of PRV-challenged mice by attenuating PRV-induced negative effects on the cytokine profile, immunoglobulin synthesis and TLR expression.

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Modulation of immune function and cytokine production by various levels of vitamin E supplementation during murine AIDS

Cited by 45 publications

References 26 publications

In vitro immune response of human peripheral blood cells to vitamins C and E

In vitro immune response of human peripheral blood cells to vitamins C and E

A randomized trial of multivitamin supplementation in children with tuberculosis in Tanzania

Effects of Vitamin E on Reproductive Protection in Pregnant Mice Infected with Pseudorabies Virus (PRV) via Regulating Expression of Toll-Like Receptors (TLRs) and Cytokine Balance

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