Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria

Fabersani, Emanuel; Russo, Matías; Marquez, Antonela; Abeijón-Mukdsi, Claudia; Medina, Roxana Beatriz; Gauffin-Cano, Paola

doi:10.1016/j.foodres.2018.06.014

Cited by 18 publications

(15 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This peptide acts promoting the proliferation of proinflammatory cells and cytokines, like TNF-α and IL-6. The immunomodulatory probiotic CRL431 previously showed to raise leptin levels in mice under a caloric restriction diet (16). In general, it is expected that positive impacts of probiotics on obesity and associated metabolic disorders are related to a decrease in serum leptin values or leptin expression (10,38,39).…”

Section: Discussionmentioning

confidence: 99%

Lactic Acid Bacteria Strains Differently Modulate Gut Microbiota and Metabolic and Immunological Parameters in High-Fat Diet-Fed Mice

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background: Dietary strategies, including the use of probiotics as preventive agents that modulate the gut microbiota and regulate the function of adipose tissue, are suitable tools for the prevention or amelioration of obesity and its comorbidities. We aimed to evaluate the effect of lactic acid bacteria (LAB) with different adipo- and immuno-modulatory capacities on metabolic and immunological parameters and intestinal composition microbiota in high-fat-diet-induced in mice fed a high-fat dietMethods: Balb/c weaning male mice were fed a standard (SD) or high-fat diet (HFD) with or without supplementation with Limosilactobacillus fermentum CRL1446 (CRL1446), Lactococcus lactis CRL1434 (CRL1434), or Lacticaseibacillus casei CRL431 (CRL431) for 45 days. Biochemical and immunological parameters, white-adipose tissue histology, gut microbiota composition, and ex vivo cellular functionality (adipocytes and macrophages) were evaluated in SD and HFD mice.Results: CRL1446 and CRL1434 administration, unlike CRL431, induced significant changes in the body and adipose tissue weights and the size of adipocytes. Also, these strains caused a decrease in plasmatic glucose, cholesterol, triglycerides, leptin, TNF-α, IL-6 levels, and an increase of IL-10. The CRL1446 and CRL1434 obese adipocyte in ex vivo functionality assays showed, after LPS stimulus, a reduction in leptin secretion compared to obese control, while with CRL431, no change was observed. In macrophages from obese mice fed with CRL1446 and CRL1434, after LPS stimulus, lower levels of MCP-1, TNF-α, IL-6 compared to obese control were observed. In contrast, CRL431 did not induce modification of cytokine values. Regarding gut microbiota, all strain administration caused a decrease in Firmicutes/Bacteroidetes index and diversity. As well as, related to genus results, all strains increased, mainly the genera Alistipes, Dorea, Barnesiella, and Clostridium XIVa. CRL1446 induced a higher increase in the Lactobacillus genus during the study period.Conclusions: The tested probiotic strains differentially modulated the intestinal microbiota and metabolic/immunological parameters in high-fat-diet-induced obese mice. These results suggest that CRL1446 and CRL1434 strains could be used as adjuvant probiotics strains for nutritional treatment to obesity and overweight. At the same time, the CRL431 strain could be more beneficial in pathologies that require regulation of the immune system.

show abstract

Section: Discussionmentioning

confidence: 99%

Lactic Acid Bacteria Strains Differently Modulate Gut Microbiota and Metabolic and Immunological Parameters in High-Fat Diet-Fed Mice

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the Firmicutes phylum, several studies assessed the impact of 25-40% CR based on a normal ad libitum diet and showed an increase of Lactobacillaceae [16,94], such as Lactobacillus spp. [17][18][19][20][21][22], Erysipelotrichaceae [16,94], and Ruminococcaceae [94] in CR rodents compared with normal-diet rodents. Conversely, a decrease of Lactococcus spp., [22], Lachnospiraceae [22,95] and Clostridiales [94,95] was found in CR rodents compared with controls.…”

Section: Caloric Restriction (Cr) and Gut Microbiota Variationsmentioning

confidence: 98%

“…CR could also impact the composition of Bacteroidetes, increasing the abundance of Bacteroidaceae [16,17,20,21,94], Proteobacteria [17,21,22,96], and Verrucomicrobia [16,96] with an increase of Akkermansia muciniphila counts [16]. In the Actinobacteria phylum, in several studies [17,[20][21][22], counts of some Bifidobacterium spp. increased in CR animals compared with normal diet-fed animals.…”

Section: Caloric Restriction (Cr) and Gut Microbiota Variationsmentioning

confidence: 99%

“…Several studies found an enrichment of Lactobacillus spp. induced by different dietary restrictions in mice [17,20] and humans [98]. An interesting study [20] compared the effects of the administration of the feruloyl esterase-producing strain Lactobacillus fermentum CRL1446 to a CR diet, compared to a control diet and a CR diet.…”

Section: Gut Microbiota and Host Metabolism During Dietary Restrictionsmentioning

confidence: 99%

“…In parallel, numerous studies have reported changes in microbiota composition in both preclinical and clinical models during dietary restrictions [16][17][18][19][20][21][22][23][24]. Gut microbiota is a complex community of over 100 trillion bacteria, yeasts, viruses, and parasites influencing host physiology, metabolism, and immune function [25].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases

Rinninella

Cintoni²,

Raoul

et al. 2020

Microorganisms

View full text Add to dashboard Cite

In recent decades, there has been a growing interest in dietary restrictions for their promising effects on longevity and health span. Indeed, these strategies are supposed to delay the onset and burden of non-communicable diseases (NCDs) such as obesity, diabetes, cancer and neurological and gastrointestinal inflammatory diseases. At the same time, the gut microbiota has been shown to play a crucial role in NCDs since it is actively involved in maintaining gut homeostasis through its impact on nutrients metabolism, gut barrier, and immune system. There is evidence that dietary restrictions could slow down age-related changes in the types and numbers of gut bacteria, which may counteract gut dysbiosis. The beneficial effects on gut microbiota may positively influence host metabolism, gut barrier permeability, and brain functions, and subsequently, postpone the onset of NCDs prolonging the health span. These new insights could lead to the development of novel strategies for modulating gut microbiota with the end goal of treating/preventing NCDs. This review provides an overview of animal and human studies focusing on gut microbiota variations during different types of dietary restriction, in order to highlight the close relationship between gut microbiota balance and the host’s health benefits induced by these nutritional regimens.

show abstract

Diet-Induced Alterations in Gut Microbiota Composition and Function

Rinninella

Cintoni

Raoul

et al. 2022

Comprehensive Gut Microbiota

View full text Add to dashboard Cite

Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria

Abstract: Modulation of intestinal microbiota and IMMUNO-metabolic parameters by caloric restriction and lactic acid bacteria. Frin (2017),

Cited by 18 publications

References 66 publications

Lactic Acid Bacteria Strains Differently Modulate Gut Microbiota and Metabolic and Immunological Parameters in High-Fat Diet-Fed Mice

Lactic Acid Bacteria Strains Differently Modulate Gut Microbiota and Metabolic and Immunological Parameters in High-Fat Diet-Fed Mice

Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases

Diet-Induced Alterations in Gut Microbiota Composition and Function

Contact Info

Product

Resources

About