Modulation of murine pluripotential stem cell proliferation in vivo by lithium carbonate

Vs, Gallicchio; Chen, MG

doi:10.1182/blood.v56.6.1150.1150

Cited by 43 publications

(15 citation statements)

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“…Dealing with lithium poisoning, cytopenias are scarcely reported. Lithium can reduce erythroid progenitor growth in vitro [ 7 ]. On mice [ 8 ], lithium treatment with 20 mg/kg daily can reduce erythropoiesis.…”

Section: Discussionmentioning

confidence: 99%

Lithium: one drug, five complications

et al. 2017

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BackgroundLithium poisoning could trigger multiple complications. We report the case of a lithium poisoning with five complications that are described for the first time together.Case reportA 60-year-old woman was admitted in our intensive care unit for altered consciousness. Severe lithium intoxication was diagnosed (lithium plasmatic level 8.21 mmol/l) associated with acute oliguric kidney failure. Continuous renal replacement therapy was started immediately. Orotracheal intubation was quickly required because of status epilepticus. Medullary aplasia happened 48 h after the patient was intubated. Infectious and immunological causes were ruled out and lithium poisoning was considered as the most likely etiology. Iterative blood and platelet transfusion were required. Severe polyneuropathy was diagnosed on the 5th day after admission. The patient showed a peripheral tetraparesia and cranial nerve failure while lithium plasmatic level had decreased to a therapeutic level. Conversely, urine output increased and hypernatremia promptly occurred, which led to diabetes insipidus diagnosis. Neuropathy decreased in 72 h and the patient was definitely extubated by the 11th day. Hematologic disturbances decreased and no blood transfusion would be required after the 8th day. The patient would keep sequellas of the poisoning. Thin motricity would still be altered and polyuria would remain. Diffuse alopecia was promptly observed, with no iron deficiency or thyroid disturbance.ConclusionIn addition to presenting this case report, we herein discuss the drug causality, the consequences, and the plausible pathophysiology of these five situations.

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Section: Discussionmentioning

confidence: 99%

Lithium: one drug, five complications

et al. 2017

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“…Lithium carbonate does not injure the liver in the routine dose and is a perfect substitution for ATD. Study has found that an additive effect of increasing white blood cells was observed in patients treated with lithium carbonate because it may modulate granulocytopoiesis [ 20 ]. Moreover, lithium salts can not only increase the level of CD34 but also induce granulocyte colony-stimulating factor and increase the number of neutrophils by stimulating bone marrow; thus, it is a good choice in patients with leucopenia or agranulocytosis [ 21 – 23 ].…”

Section: Discussionmentioning

confidence: 99%

Lithium Carbonate in the Treatment of Graves’ Disease with ATD-Induced Hepatic Injury or Leukopenia

Ruan

Liu

Chen

et al. 2015

International Journal of Endocrinology

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Objective. GD with ATD-induced hepatic injury or leukopenia occurs frequently in clinical practice. The purpose of the present study was to observe the clinical effect of lithium carbonate on hyperthyroidism in patients with GD with hepatic injury or leukopenia. Methods. Fifty-one patients with GD with hepatic injury or leukopenia participated in the study. All patients were treated with lithium carbonate, in addition to hepatoprotective drugs or drugs that increase white blood cell count. Thyroid function, liver function, and white blood cells were measured. Clinical outcomes were observed after a 1-year follow-up. Results. After treatment for 36 weeks, symptoms of hyperthyroidism and the level of thyroid hormones were improved and liver function, and white blood cells returned to a normal level. Twelve patients (23.5%) obtained clinical remission, 6 patients (11.8%) relapsed after withdrawal, 25 patients (49.0%) received radioiodine therapy, and 8 patients (15.7%) underwent surgical procedures after lithium carbonate treatment. Conclusion. Lithium carbonate has effects on the treatment of mild-to-moderate hyperthyroidism caused by GD, and it is particularly suitable for patients with ATD-induced hepatic injury or leukopenia.

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“…Li also acts on pluripotent stem cells, platelet production and megakaryocytes [71]. Li carbonate at a dose of 1milliequivalent per litre (mEq/l) of solution is shown to increase bone marrow CFUs and granulopoiesis [72]. PI3Kand mTOR signalling is regulated by GSK3.…”

Section: Lithium and Haematopoiesismentioning

confidence: 99%

Lithium: Immunomodulatory and Anti-Infectious Activities

2019

JPR

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Lithium (Li), a well-known immunomodulatory agent, has been in use for the treatment of several infectious diseases. Li mainly acts through GSK3β inactivation and several other signalling pathways, which are directly involved in the activation of innate immune system. Li therapy has been shown to cause effective modulation of various inflammatory cytokines, and has also been shown to boost immunity in several disease models. Apart from treatment for mania, Li has also been proved to be effective against infections caused by viruses, bacteria, parasites, and certain life-style disorders. Its effects, ranging from common defensive capabilities to complex pathways for protection of human body, make Li extraordinary. Thus, Li is an absolute requirement that can be a solution for some of the immune related disorders. This review mainly focuses on pharmacology, immune reactions of different cell types, and anti-infectious activities of Li.

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Modulation of murine pluripotential stem cell proliferation in vivo by lithium carbonate

Cited by 43 publications

References 0 publications

Lithium: one drug, five complications

Lithium: one drug, five complications

Lithium Carbonate in the Treatment of Graves’ Disease with ATD-Induced Hepatic Injury or Leukopenia

Lithium: Immunomodulatory and Anti-Infectious Activities

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