1987
DOI: 10.1007/bf00199836
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Modulation of natural killer cell activity in stage I postmenopausal breast cancer patients on low-dose aminoglutethimide

Abstract: Natural killer (NK) cells are important in surveillance against malignant cells. The activity of NK cells can be modulated by naturally occurring mediators; interferon, interleukin-2, and hormones. Low-dose aminoglutethimide (Ag 250 mg/day) inhibits the peripheral aromatization of androstenedione hence decreasing circulating estrogens. Of ten patients treated, seven were evaluable. There was a statistically significant increase in NK activity (P = 0.0025) following the administration of Ag. There was no consis… Show more

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Cited by 11 publications
(6 citation statements)
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“…These specialized T cells are capable of recognizing various pathogens including tumor cells. Finally, although hormonal therapy can dampen the immune response, aromatase inhibitors used in vitro rendered tumor cells more sensitive to lysis by human peripheral blood mononuclear cells via monocyte-mediated antibodydependent cellular cytotoxicity [26] and may increase NK cell activity [27]. Although our work suggests common adjuvant breast cancer therapies do not inhibit the development of cellular immunity, numbers of subjects were too small to determine whether these therapies could augment the vaccinated immune response.…”
Section: Discussionmentioning
confidence: 92%
“…These specialized T cells are capable of recognizing various pathogens including tumor cells. Finally, although hormonal therapy can dampen the immune response, aromatase inhibitors used in vitro rendered tumor cells more sensitive to lysis by human peripheral blood mononuclear cells via monocyte-mediated antibodydependent cellular cytotoxicity [26] and may increase NK cell activity [27]. Although our work suggests common adjuvant breast cancer therapies do not inhibit the development of cellular immunity, numbers of subjects were too small to determine whether these therapies could augment the vaccinated immune response.…”
Section: Discussionmentioning
confidence: 92%
“…Transformed cells which evade immunosurveillance, for example because they do not express 'non-self' antigens on their surfaces or because they have effective defence mechanisms against immune attack, will be 'fitter' in a Darwinian sense and have a survival advantage. The mechanism of action of tamoxifen, which is the most clinically-effective chemopreventative agent to date (Fisher et al 1998), may include increased immunosurveillance through increased natural killer cell densities (Berry et al 1987). Dietary components that enhance the immune system's ability to identify and target for apoptosis transformed cells will have potential as effective chemopreventative agents.…”
Section: Discussionmentioning
confidence: 99%
“…Berry et al (44) described an increase in NK cell activity in postmenopausal breast cancer patients on a low dose of aminoglutethimide, a first-generation aromatase inhibitor.…”
Section: First-generation Aromatase Inhibitor (Aminoglutethimide)mentioning
confidence: 99%