Modulation of Oxidative Stress in Cardiovascular Diseases

Jha, Jay C.; Bose, Madhura; Jandeleit‐Dahm, Karin

doi:10.1007/978-981-13-8946-7_10

Cited by 3 publications

(2 citation statements)

References 113 publications

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“…8,53 Another important disease whose progression has been correlated with ROS is cardiovascular disease (CVD), 54 which includes atherosclerosis and myocardial infarction among others, some of the major causes of death worldwide. 55 Increased ROS concentrations have been correlated to CVD through the activation of several signaling cascades in the coronary endothelium, a vascular tissue, during pathogenic cardiovascular events.…”

Section: Overview Of the (Patho)physiologicalmentioning

confidence: 99%

Small-Molecule Inhibitors of Reactive Oxygen Species Production

2021

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Reactive oxygen species (ROS) are involved in physiological cellular processes including differentiation, proliferation, and apoptosis by acting as signaling molecules or regulators of transcription factors. The maintenance of appropriate cellular ROS levels is termed redox homeostasis, a balance between their production and neutralization. High concentrations of ROS may contribute to severe pathological events including cancer, neurodegenerative, and cardiovascular diseases. In recent years, approaches to target the sources of ROS production directly in order to develop tool compounds or potential therapeutics have been explored. Herein, we briefly outline the major sources of cellular ROS production and comprehensively review the targeting of these by small-molecule inhibitors. We critically assess the value of ROS inhibitors with different mechanisms-of-action, including their potency, mode-of-action, known off-target effects, and clinical or preclinical status, while suggesting future avenues of research in the field.

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Section: Overview Of the (Patho)physiologicalmentioning

confidence: 99%

Small-Molecule Inhibitors of Reactive Oxygen Species Production

2021

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“…It is proven that NS could increase SOD activity, which is associated with reducing hydrogen peroxide and superoxide radical generation (Hassan, Akhtar, Ahmed, Ahmad, & Najmi, 2017). The impaired antioxidant system could augment ROS and pro-inflammatory markers, resulting in increased adhesion molecule expression and eventually atherosclerosis progression (Jha, Bose, & Jandeleit-Dahm, 2019). NS could exert its beneficial effect through this pathway.…”

Section: The Effect Of Ns Oil On Oxidationmentioning

confidence: 99%

Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double‐blind, placebo‐control clinical trial

Tavakoli‐Rouzbehani

Abbasnezhad

Kheirouri

et al. 2022

Phytotherapy Research

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A therapeutic compound with antioxidant and anti-inflammatory effects might be a practical approach in endothelial dysfunction caused by oxidation and inflammation associated with atherosclerosis. Therefore, we aim to examine the efficacy of Nigella sativa (NS) oil supplementation on endothelial function and atherogenic indices in coronary artery disease (CAD) patients. Sixty individuals aged between 35 to 65 years old were recruited and divided into two groups, receiving either 2 g/daily of NS oil or sunflower oil as the placebo for 8 weeks. Serum levels of adhesion molecules, oxidative markers, and atherogenic parameters were evaluated at the starting point and the end of supplementation. Serum levels of vascular cell adhesion protein 1 (sVCAM-1) [À264.44 95% C, (156.83, 372.04)], intercellular adhesion molecule 1 (sICAM-1) [À132.38 95% C, (40.64, 224.1)], and malondialdehyde (MDA) [À0.21 95% C, (0.03, 0.40)] declined significantly following NS supplementation, while total antioxidant capacity increased [0.03 95% C, (0.03, 0.16)]. NS oil supplementation demonstrated a potential beneficial effect on endothelial function by reducing ICAM-1, VCAM-1 levels and affecting oxidative markers. However, further studies are necessary to elucidate NS oil as a therapeutic agent and complementary therapy in patients with stable CAD.

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Impact of COVID-19 on Employee Behavior: Stress and Coping Mechanism During WFH (Work From Home) Among Service Industry Employees

Sahni

2020

IJOM

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The continuing crisis of Coronavirus-19 disease (COVID-19) has changed our lives considerably; imposing the need for various modifications for organizations and individuals to cope up in this testing time. This study is undertaken to have an insight on how organizations and individuals adapt to these changes and challenges. The impact of coronavirus on human body is well known and more research is underway but what it does to the human behavior and the psychosocial effects are yet to be unraveled. To dive deep into the behavioral consequences of such pandemic, 23 in-depth interviews (Male 12; female 13, average age of 39 years) were conducted with middle level managers in public and private service industry of Riyadh, Saudi Arabia. Using the Conservation of resource theory (COR), this paper explores the employee’s perception of different types of stressors and examine a variety of coping mechanisms including the type of organizational support provided during this crisis. The findings of the interview suggest that the stress levels were moderate to high among all the participants. The main themes emerged from the interviews were categorized into five; (i) Triggers of stress (ii) Organizational support (iii) Coping strategies & resources (iv) Blurred boundaries during WFH and (v) Positivity in this crisis. The study presents an integrated Stress Model with key triggers, coping strategies (resources), organization support and outcome. The triggers inducing stress includes fear of unknown, ineffective communication at work, lack of clarity and direction, interruptions during WFH resulting in loss of resources like time and energy. All this might disturb employee’s mental health leading to prolonged stress or even psychosomatic diseases. Therefore, it is an important issues which need to be given priority in all organizations. The findings support the notion that there is a dire need for psycho-social support, community support and an effective system of organizational support to sustain employee’s emotional and mental wellbeing. The findings of the study are valuable and have urgent policy implications for devising a special EAP for crisis like COVID-19 and any future cases. Although the lockdown would be gradually eased, organizations need to rethink about different alternatives to work. The need of the hour is to be more agile and flexible to foster creativity and innovation.

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Modulation of Oxidative Stress in Cardiovascular Diseases

Cited by 3 publications

References 113 publications

Small-Molecule Inhibitors of Reactive Oxygen Species Production

Small-Molecule Inhibitors of Reactive Oxygen Species Production

Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double‐blind, placebo‐control clinical trial

Impact of COVID-19 on Employee Behavior: Stress and Coping Mechanism During WFH (Work From Home) Among Service Industry Employees

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