2003
DOI: 10.1046/j.1523-1755.2003.00804.x
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Modulation of renal epithelial barrier function by mitogen-activated protein kinases (MAPKs): Mechanism of cyclosporine A–induced increase in transepithelial resistance

Abstract: The results presented here suggest that activation of the ERK 1/2 MAPK cascade is important in the regulation of the paracellular permeability in MDCK cells. Activation of this pathway appears to be pivotal to the CsA-induced increase in TER.

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Cited by 42 publications
(37 citation statements)
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“…This is in agreement with data from Horvath et al (2002) showing impaired cell-cell contact after noncytotoxic doses of OTA. Additionally, recent data indicate opposite influence of ERK1/2 and p38 on renal paracellular permeability (Kiely et al, 2003), which is in agreement with the above-described activation of MAPKs by OTA. Inhibition of ERK1/2 together with 100 nM OTA did not further increase epithelial leakage, whereas it dramatically decreased total cell number.…”
Section: Discussionsupporting
confidence: 89%
“…This is in agreement with data from Horvath et al (2002) showing impaired cell-cell contact after noncytotoxic doses of OTA. Additionally, recent data indicate opposite influence of ERK1/2 and p38 on renal paracellular permeability (Kiely et al, 2003), which is in agreement with the above-described activation of MAPKs by OTA. Inhibition of ERK1/2 together with 100 nM OTA did not further increase epithelial leakage, whereas it dramatically decreased total cell number.…”
Section: Discussionsupporting
confidence: 89%
“…Inhibition of this pathway significantly attenuated the TGF-␤1-induced increase in TER after 48 and 72 h of treatment. However, we observed no significant change in the CsA-induced effect when we inhibited the p38 MAPK pathway (6), which signifies that TGF-␤1 may also be mediating its effect on barrier function via the p38 MAPK pathway, but this particular signaling route is not triggered by exposure to CsA.…”
Section: Discussioncontrasting
confidence: 55%
“…MDCK II cells (22) that were obtained from the American Type Culture Collection (Middlesex, UK) were cultured as before (6). CsA was prepared as a stock solution (4.2 mM) in 100% EtOH.…”
Section: Cell Culture and Treatmentmentioning
confidence: 99%
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