Modulation of sleep: A new approach of treating memory impairment in schizophrenia?

Göder, Robert; Boigs, Margret; Braun, Susanne; Friege, Lars; Fritzer, Gunther; Aldenhoff, Josef B.; Hinze-Selch, D.

doi:10.1055/s-2003-825340

Cited by 2 publications

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“…In healthy individuals, REM sleep deprivation results in memory impairment (33); however, more recently NREM sleep has been linked to memory consolidation (34). In humans with schizophrenia, a direct link is seen between decreased amounts of NREM sleep and impaired visuospatial memory (35). This suggests that the stages of sleep and their electrophysiological characteristics influence neuronal plasticity.…”

Section: Discussionmentioning

confidence: 99%

Dysfunction of the Scn8a Voltage-gated Sodium Channel Alters Sleep Architecture, Reduces Diurnal Corticosterone Levels, and Enhances Spatial Memory

Papale

Paul

Sawyer

et al. 2010

Journal of Biological Chemistry

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Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of transient depolarizing currents and play a critical role in the electrical signaling between neurons. A null mutation in the VGSC gene SCN8A, which encodes the transmembrane protein Na v 1.6, was identified previously in a human family. Heterozygous mutation carriers displayed a range of phenotypes, including ataxia, cognitive deficits, and emotional instability. A possible role for SCN8A was also proposed in studies examining the genetic basis of attempted suicide and bipolar disorder. In addition, mice with a Scn8a loss-of-function mutation (Scn8a

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Section: Discussionmentioning

confidence: 99%

Dysfunction of the Scn8a Voltage-gated Sodium Channel Alters Sleep Architecture, Reduces Diurnal Corticosterone Levels, and Enhances Spatial Memory

Papale

Paul

Sawyer

et al. 2010

Journal of Biological Chemistry

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“…Likewise, recognition memory performance for landscapes correlates with amounts of SWS gained during a postlearning nap (25). SWS deprivation impairs the retention of spatial rotation abilities (26), and memory for spatial locations is impaired in proportion to lower amounts of SWS in schizophrenic patients (27). Besides, extensive navigation in a virtual maze increases stage II sleep duration on the first posttraining night (28).…”

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confidence: 99%

Sleep after spatial learning promotes covert reorganization of brain activity

Orban

Rauchs

Balteau

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

154

130

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Sleep promotes the integration of recently acquired spatial memories into cerebral networks for the long term. In this study, we examined how sleep deprivation hinders this consolidation process. Using functional MRI, we mapped regional cerebral activity during place-finding navigation in a virtual town, immediately after learning and 3 days later, in subjects either allowed regular sleep (RS) or totally sleep-deprived (TSD) on the first posttraining night. At immediate and delayed retrieval, place-finding navigation elicited increased brain activity in an extended hippocamponeocortical network in both RS and TSD subjects. Behavioral performance was equivalent between groups. However, striatal navigation-related activity increased more at delayed retrieval in RS than in TSD subjects. Furthermore, correlations between striatal response and behavioral performance, as well as functional connectivity between the striatum and the hippocampus, were modulated by posttraining sleep. These data suggest that brain activity is restructured during sleep in such a way that navigation in the virtual environment, initially related to a hippocampus-dependent spatial strategy, becomes progressively contingent in part on a response-based strategy mediated by the striatum. Both neural strategies eventually relate to equivalent performance levels, indicating that covert reorganization of brain patterns underlying navigation after sleep is not necessarily accompanied by overt changes in behavior.functional MRI ͉ hippocampus ͉ sleep deprivation ͉ memory consolidation ͉ striatum T he hypothesis that sleep represents a crucial, albeit not always indispensable, neurophysiological state that actively promotes learning-dependent brain plasticity (1-5) has become a main topic of interest in neuroscience. In this view, an active processing of freshly acquired memories may occur in the sleeping brain, supporting the gradual consolidation process by which labile recent memories are restructured and incorporated into stable memories for the long term (6, 7).Memories that can be consciously and symbolically expressed belong to the declarative memory system. At the neuroanatomical level, their encoding and initial maintenance rely upon the integrity of the medial temporal lobe, with the hippocampus at its core (8, 9). Episodic memory for personally experienced events set in a spatiotemporal context is defined as a subclass of declarative memory (10). Animal (11) and human (12) studies suggest that the hippocampus is involved in spatial learning, because encoding is based on a flexible knowledge of relationships between environmental cues. Hippocampus-dependent spatial memory in animals is thus phylogenetically viewed as a homologue of human episodic͞ declarative memory (13,14). However, spatial navigation in a well learned environment may also be mediated by the striatum through the expression of stimulus-response associations (15, 16). Current research further suggests that rodents (17, 18) and humans (19) tend to initially use a hippocampus-de...

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Modulation of sleep: A new approach of treating memory impairment in schizophrenia?

Cited by 2 publications

References 0 publications

Dysfunction of the Scn8a Voltage-gated Sodium Channel Alters Sleep Architecture, Reduces Diurnal Corticosterone Levels, and Enhances Spatial Memory

Dysfunction of the Scn8a Voltage-gated Sodium Channel Alters Sleep Architecture, Reduces Diurnal Corticosterone Levels, and Enhances Spatial Memory

Sleep after spatial learning promotes covert reorganization of brain activity

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