Modulation of somatosensation by transcranial magnetic stimulation over somatosensory cortex: a systematic review

Tang, Dinglan; Niziolek, Caroline A.; Parrell, Benjamin

doi:10.1007/s00221-023-06579-9

Cited by 4 publications

(5 citation statements)

References 109 publications

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“…Moreover, although the threshold changes induced by iTBS did differ from the baseline phase, they did not show significant differences when directly compared to control sessions (sham or no stimulation). This is consistent with previous TBS studies on the hand showing that the effect of iTBS over S1 tends to be less robust and stable than that of cTBS (see review, Tang et al, 2023). Spatial amplitude discrimination relies on a combination of excitation within and inhibition between adjacent cortical columns in the S1 (Friedman et al, 2008).…”

Section: Discussionsupporting

confidence: 93%

“…Participants were trained to maintain the target level of muscle contraction using EMG feedback from the electrodes placed on the tongue, displayed visually on a computer monitor. S1 was initially localized by moving 2 cm posterior from M1 hotspot on the cortex as measured using Brainsight Neuronavigation (Tang et al, 2023). If single-pulse TMS over this region elicited MEPs from the tongue muscles, the coil was moved posteriorly until tongue MEPs were no longer elicited.…”

Section: Methodsmentioning

confidence: 99%

“…Changes in response properties of S1 neurons and local excitatory/inhibitory circuitry in S1 have been observed in animals in response to manipulation of sensory experience (Blake et al, 2010; Cheetham et al, 2007) and repetitive intracortical microstimulation (Dinse et al, 1997; Heusler et al, 2000). In humans, emerging studies have used forms of repetitive transcranial magnetic stimulation (rTMS) as a tool to investigate somatosensory perception (see review, Tang et al, 2023). More recently, theta burst stimulation (TBS) has gained popularity and has been shown to modulate both somatosensory cortex activity and somatosensory perception (Kumar et al, 2019; Ragert et al, 2008; Rai et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Theta-burst stimulation over primary somatosensory cortex modulates tactile acuity of tongue

Tang,

Tommerdahl,

Niziolek

et al. 2024

Preprint

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BackgroundEmerging studies in humans have established the modulatory effects of repetitive transcranial magnetic stimulation (rTMS) over primary somatosensory cortex (S1) on somatosensory cortex activity and perception. However, to date, research in this area has primarily focused on the hand and fingers, leaving a gap in our understanding of the modulatory effects of rTMS on somatosensory perception of the orofacial system and speech articulators.ObjectiveThe present study aimed to examine the effects of different types of theta-burst stimulation—continuous TBS (cTBS), intermittent TBS (iTBS), or sham—over the tongue representation of left S1 on tactile acuity of the tongue.MethodsIn a repeated-measures design, fifteen volunteers participated in four separate sessions, where cTBS, iTBS, sham, or no stimulation was applied over the tongue representation of left S1. Effects of TBS were measured on both temporal and spatial perceptual acuity of tongue using a custom vibrotactile stimulator.ResultsCTBS significantly impaired spatial amplitude threshold at the time window of 16-30 minutes after stimulation, while iTBS improved it at the same time window. The effect of iTBS, however, was smaller than cTBS. In contrast, neither cTBS nor iTBS had any effect on the temporal discrimination threshold.ConclusionsThe current study establishes the validity of using TBS to modulate somatosensory perception of the orofacial system. Directly modifying somatosensation in the orofacial system has the potential to benefit clinical populations with abnormal tactile acuity, improve our understanding of the role of sensory systems in speech production, and enhance speech motor learning and rehabilitation.HighlightsTheta-burst stimulation (TBS) can modulate somatosensation in the orofacial systemcTBS over S1 impaired spatial acuity of tongueiTBS over S1 improved spatial acuity of tongue

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Theta-burst stimulation over primary somatosensory cortex modulates tactile acuity of tongue

Tang,

Tommerdahl,

Niziolek

et al. 2024

Preprint

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“…Administering oral morphine among 14 healthy adults modulated the medial frontopolar cortex area (mFP; medial Brodmann area10) [ 23 ]. Noninvasive transcranial magnetic stimulation stimulated the prefrontal cortex (PFC) [ 24 ] or primary somatosensory cortex (S1) and the second somatosensory cortex (S2) to control pain [ 25 ]. Using 15 healthy adult volunteers, VR gaming altered PFC to control thermal pain, in which functional near-infrared spectroscopy captured PFC and S1/S2 signals [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial

Jain,

Armstrong,

Luna

et al. 2024

PLOS Digit Health

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Key features of virtual reality (VR) that impact the effectiveness of pain reduction remain unknown. We hypothesized that specific features of the VR experience significantly impact VR’s effectiveness in reducing pain during pediatric burn dressing care. Our randomized controlled trial included children 6 to 17 years (inclusive) who were treated in the outpatient clinic of an American Burn Association–verified pediatric burn center. Participants were randomly assigned (1:1:1) to active VR (playing the VR), passive VR (immersed in the same VR environment without interactions), or standard-of-care. On a scale from 0 to 100, participants rated overall pain (primary outcome) and features of the VR experience (game realism, fun, and engagement). Path analysis assessed the interrelationships among these VR key features and their impact on self-reported pain scores. From December 2016 to January 2019, a total of 412 patients were screened for eligibility, and 90 were randomly assigned (31 in the active VR group, 30 in the passive VR group, and 29 in the standard-of-care group). The current study only included those in the VR groups. The difference in median scores of VR features was not statistically significant between the active (realism, 77.5 [IQR: 50–100]; fun, 100 [IQR: 81–100]; engagement, 90 [IQR: 70–100]) and passive (realism, 72 [IQR: 29–99]; fun, 93.5 [IQR: 68–100]; engagement, 95 [IQR: 50–100]) VR distraction types. VR engagement had a significant direct (-0.39) and total (-0.44) effect on self-reported pain score (p<0.05). Key VR features significantly impact its effectiveness in pain reduction. The path model suggested an analgesic mechanism beyond distraction. Differences in VR feature scores partly explain active VR’s more significant analgesic effect than passive VR. Trial Registration: ClinicalTrials.gov Identifier: NCT04544631.

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“… 17 More importantly, in a study that investigated treatment effects of rTMS with DLPFC targeting in depression, these regions have also been observed with alterations after a seed‐based connectivity analysis. 28 Notably, somatosensory regions are related to proprioception, 29 while limbic regions including cingulate cortex usually are in charge of receiving inputs or external stimulations from other brain regions and involved in complicated and interconnected cognitive and emotional processing. 30 While the TMS has been suggested to act through a top‐down mechanism, 27 it could be inferred that some specific neural circuit is evoked after DLPFC stimulation, in which somatosensory regions percept the stimulations whereas the limbic regions process them.…”

Section: Discussionmentioning

confidence: 99%

The acute effects of repetitive transcranial magnetic stimulation on laminar diffusion anisotropy of neocortical gray matter

Zhang

Liu

Zhao

et al. 2023

MedComm

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Repetitive transcranial magnetic stimulation (rTMS) is increasingly used to treat neuropsychiatric disorders. Inhibitory and excitatory regimens have been both adopted but the exact mechanism of action remains unclear, and investigating their differential effects on laminar diffusion profiles of neocortex may add important evidence. Twenty healthy participants were randomly assigned to receive a low‐frequency/inhibitory or high‐frequency/excitatory rTMS targeting the left dorsolateral prefrontal cortex (DLPFC). With the brand‐new submillimeter diffusion tensor imaging of whole brain and specialized surface‐based laminar analysis, fractional anisotropy (FA) and mean diffusion (MD) profiles of cortical layers at different cortical depths were characterized before/after rTMS. Inhibitory and excitatory rTMS both showed impacts on diffusion metrics of somatosensory, limbic, and sensory regions, but different patterns of changes were observed—increased FA with inhibitory rTMS, whereas decreased FA with excitatory rTMS. More importantly, laminar analysis indicated laminar specificity of changes in somatosensory regions during different rTMS patterns—inhibitory rTMS affected the superficial layers contralateral to the DLPFC, while excitatory rTMS led to changes in the intermediate/deep layers bilateral to the DLPFC. These findings provide novel insights into acute neurobiological effects on diffusion profiles of rTMS that may add critical evidence relevant to different protocols of rTMS on neocortex.

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Modulation of somatosensation by transcranial magnetic stimulation over somatosensory cortex: a systematic review

Cited by 4 publications

References 109 publications

Theta-burst stimulation over primary somatosensory cortex modulates tactile acuity of tongue

Theta-burst stimulation over primary somatosensory cortex modulates tactile acuity of tongue

Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial

The acute effects of repetitive transcranial magnetic stimulation on laminar diffusion anisotropy of neocortical gray matter

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