Modulation of synaptic plasticity by short-term aerobic exercise in adult mice

D’Arcangelo, Giovanna; Triossi, Tamara; Buglione, Antonio; Melchiorri, G; Tancredi, Virginia

doi:10.1016/j.bbr.2017.05.058

Cited by 18 publications

(17 citation statements)

References 25 publications

(26 reference statements)

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“…Moreover, training significantly reduced serum glucose, LDH in both young and old animals and improved the weight in young animals, indicating beneficial effects of the continuous progressive training protocol. Actually, we recently demonstrated that a short-term aerobic exercise in adult mice enhances body weight and synaptic plasticity if training load is adequate and appropriate recovery periods are respected [ 37 ]. In the present work young animals, trained for a longer period (3 months), exhibit an enhancement in synaptic plasticity and old mice present a blockade reversal of the LTP induction phase indicating that motor activity exerts positive effects on neuronal plasticity.…”

Section: Discussionmentioning

confidence: 99%

Modulation of GDF11 expression and synaptic plasticity by age and training

et al. 2017

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The Growth Differentiation Factor 11 (GDF11) has been controversially involved in the aging/rejuvenation process. To clarify whether GDF11 is differently expressed during aging, we have evaluated GDF11 levels in skeletal muscles and hippocampi of young and old mice, sedentary or subjected to a 12-weeks triweekly training protocol. The results of real-time PCR and Western blot analyses indicate that skeletal muscles of sedentary old mice express higher levels of GDF11 compared to young animals (p < 0.05). Conversely, in hippocampi no significant differences of GDF11 expression are detected. Analysis of long-term potentiation, a synaptic plasticity phenomenon, reveals that population spikes in response to a tetanic stimulus are significantly higher in sedentary young mice than in old animals (p < 0.01). Training induces a significant improvement of long-term potentiation in both young and old animals (p < 0.05), an increase (p < 0.05) of skeletal muscle GDF11 levels in young mice and a reduction of GDF11 expression in hippocampi of old mice (p < 0.05). Overall, data suggest that GDF11 can be considered an aging biomarker for skeletal muscles. Moreover, physical exercise has a positive impact on long-term potentiation in both young and old mice, while it has variable effects on GDF11 expression depending on age and on the tissue analyzed.

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Section: Discussionmentioning

confidence: 99%

Modulation of GDF11 expression and synaptic plasticity by age and training

et al. 2017

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“…In preclinical studies, swimming showed antidepressant-like effects on anhedonia in stressed rodents along with a normalization of a stress-induced BDNF mRNA expression decrease (Jiang et al 2014). A 21-day exercise regimen in rats transiently increased LTP in the DG of the hippocampus (Radahmadi et al 2016), although recent data suggested that, if motor activity could exert positive effects on cognitive processes, it was under very controlled conditions (D’Arcangelo et al 2017) and that acute swim stress could also led to LTD (Tabassum and Frey 2013). …”

Section: Neuroplasticity Changes In Mdd and The Effects Of Antidepresmentioning

confidence: 99%

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

et al. 2018

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Depression is a major health problem with a high prevalence and a heavy socioeconomic burden in western societies. It is associated with atrophy and impaired functioning of cortico-limbic regions involved in mood and emotion regulation. It has been suggested that alterations in neurotrophins underlie impaired neuroplasticity, which may be causally related to the development and course of depression. Accordingly, mounting evidence suggests that antidepressant treatment may exert its beneficial effects by enhancing trophic signaling on neuronal and synaptic plasticity. However, current antidepressants still show a delayed onset of action, as well as lack of efficacy. Hence, a deeper understanding of the molecular and cellular mechanisms involved in the pathophysiology of depression, as well as in the action of antidepressants, might provide further insight to drive the development of novel fast-acting and more effective therapies. Here, we summarize the current literature on the involvement of neurotrophic factors in the pathophysiology and treatment of depression. Further, we advocate that future development of antidepressants should be based on the neurotrophin theory.

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“…Relatedly, exercise-related, BDNF-induced neurogenesis influences synaptic development, and in turn, likely plays an important role in LTP production. Other candidate mechanisms include exercise-related alterations in cholinergic activity [27], mineralocorticoid/glucocorticoid receptor expression [29], cAMP signaling [37], and inflammatory cytokines [38].…”

Section: Non-human Studiesmentioning

confidence: 99%

The Effects of Exercise on Long-Term Potentiation: A Candidate Mechanism of the Exercise-Memory Relationship

Loprinzi¹

2019

obm neurobiol

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Objective: The objective of this paper was to evaluate the extent to which exercise may influence long-term potentiation (LTP), a key cellular correlate of episodic memory function. Methods: Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus and Google Scholar. Results: The computerized searches revealed 20 articles meeting the study criteria. Among these 20 evaluated articles, 17 were conducted in an animal model and 3 among humans. All 17 of these studies, with the exception of one, provided evidence that exercise enhances LTP. Each of the three human studies demonstrated evidence that exercise was favorably associated with LTP or LTP-like mechanisms. In animal models, exercise reliability increases LTP and lowers the threshold for LTP induction. Conclusion: Chronic exercise appears to robustly enhance LTP. The mechanisms of this effect are multifold and include, for example, exercise modulation of the structure and function of NMDA receptors.

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Modulation of synaptic plasticity by short-term aerobic exercise in adult mice

Cited by 18 publications

References 25 publications

Modulation of GDF11 expression and synaptic plasticity by age and training

Modulation of GDF11 expression and synaptic plasticity by age and training

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

The Effects of Exercise on Long-Term Potentiation: A Candidate Mechanism of the Exercise-Memory Relationship

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