Modulation of the COMT Val158Met polymorphism on resting-state EEG power

Solís, S.; Pérez-Luque, Elva; Gutiérrez-Muñoz, Mayra

doi:10.3389/fnhum.2015.00136

Cited by 4 publications

(3 citation statements)

References 56 publications

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“…Although polymorphisms of COMT and DRD4 had been linked to EEG phenotypes (Loo et al 2010 ; Solís-Ortiz et al 2015 ), these potential links had not yet been investigated within tasks examining the neurophysiological indices of frontostriatal and parietal attentional networks. Our study aimed to investigate the relationship between COMT and DRD4 polymorphisms and ICA source-resolved brain activity during a cognitive control task, and our findings suggest higher genetic penetrance for IC-derived EEG measures of cognitive control than traditional channel based measures.…”

Section: Discussionmentioning

confidence: 99%

EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes

et al. 2017

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Cognitive or executive control is a critical mental ability, an important marker of mental illness, and among the most heritable of neurocognitive traits. Two candidate genes, catechol-O-methyltransferase (COMT) and DRD4, which both have a roles in the regulation of cortical dopamine, have been consistently associated with cognitive control. Here, we predicted that individuals with the COMT Met/Met allele would show improved response execution and inhibition as indexed by event-related potentials in a Go/NoGo task, while individuals with the DRD4 7-repeat allele would show impaired brain activity. We used independent component analysis (ICA) to separate brain source processes contributing to high-density EEG scalp signals recorded during the task. As expected, individuals with the DRD4 7-repeat polymorphism had reduced parietal P3 source and scalp responses to response (Go) compared to those without the 7-repeat. Contrary to our expectation, the COMT homozygous Met allele was associated with a smaller frontal P3 source and scalp response to response-inhibition (NoGo) stimuli, suggesting that while more dopamine in frontal cortical areas has advantages in some tasks, it may also compromise response inhibition function. An interaction effect emerged for P3 source responses to Go stimuli. These were reduced in those with both the 7-repeat DRD4 allele and either the COMT Val/Val or the Met/Met homozygous polymorphisms but not in those with the heterozygous Val/Met polymorphism. This epistatic interaction between DRD4 and COMT replicates findings that too little or too much dopamine impairs cognitive control. The anatomic and functional separated maximally independent cortical EEG sources proved more informative than scalp channel measures for genetic studies of brain function and thus better elucidate the complex mechanisms in psychiatric illness.

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Section: Discussionmentioning

confidence: 99%

EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes

et al. 2017

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“…Several SNPs in the DAT1 transporter protein gene alter the recapture of dopamine[ 95 ], which have been associated with impulsivity and increased food intake[ 96 , 97 ]. A reduced COMT activity in the Val158Met polymorphism affects the degradation of dopamine and other catecholamines (epinephrine, norepinephrine) causing higher dopamine synaptic levels[ 98 , 99 ]. Stein et al[ 100 ] have proposed that Met / Met carriers be identified as “worriers” whereas the Val / Val carriers were known as “warriors” in response to stress resistance.…”

Section: Genetic Factorsmentioning

confidence: 99%

Genes, emotions and gut microbiota: The next frontier for the gastroenterologist

Panduro¹,

Rivera-Iñiguez²,

Sepúlveda-Villegas³

et al. 2017

WJG

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Most medical specialties including the field of gastroenterology are mainly aimed at treating diseases rather than preventing them. Genomic medicine studies the health/disease process based on the interaction of the human genes with the environment. The gastrointestinal (GI) system is an ideal model to analyze the interaction between our genes, emotions and the gut microbiota. Based on the current knowledge, this mini-review aims to provide an integrated synopsis of this interaction to achieve a better understanding of the GI disorders related to bad eating habits and stress-related disease. Since human beings are the result of an evolutionary process, many biological processes such as instincts, emotions and behavior are interconnected to guarantee survival. Nourishment is a physiological need triggered by the instinct of survival to satisfy the body’s energy demands. The brain-gut axis comprises a tightly connected neural-neuroendocrine circuitry between the hunger-satiety center, the dopaminergic reward system involved in the pleasure of eating and the gut microbiota that regulates which food we eat and emotions. However, genetic variations and the consumption of high-sugar and high-fat diets have overridden this energy/pleasure neurocircuitry to the point of addiction of several foodstuffs. Consequently, a gut dysbiosis generates inflammation and a negative emotional state may lead to chronic diseases. Balancing this altered processes to regain health may involve personalized-medicine and genome-based strategies. Thus, an integrated approach based on the understanding of the gene-emotions-gut microbiota interaction is the next frontier that awaits the gastroenterologist to prevent and treat GI disorders associated with obesity and negative emotions.

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“…Little is known about the genetics underlying EEG traits or pharmacologically modulated EEG, but twin studies show that heritability of resting EEG oscillations is substantial (Stassen et al 1987), particularly for PAF (Posthuma et al 2001;Smit et al 2005Smit et al , 2006 and -band oscillations with 80-90% heritability estimates (Van Beijsterveldt & van Baal 2002;Van Beijsterveldt et al 1996). The COMT polymorphism contributes to individual differences in brain oscillations, with Val homozygotes exhibiting reduced 2 and PAF compared to Met/Met carriers (Bodenmann et al 2009a;Enoch et al 2003), who exhibited greater delta, theta and beta (Solis-Ortiz et al 2015).…”

mentioning

confidence: 99%

COMT polymorphism modulates the resting‐state EEG alpha oscillatory response to acute nicotine in male non‐smokers

Bowers

Smith

Choueiry

et al. 2015

Genes Brain and Behavior

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Modulation of the COMT Val158Met polymorphism on resting-state EEG power

Cited by 4 publications

References 56 publications

EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes

EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes

Genes, emotions and gut microbiota: The next frontier for the gastroenterologist

COMT polymorphism modulates the resting‐state EEG alpha oscillatory response to acute nicotine in male non‐smokers

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