Modulation of the endogenous Annexin A1 in a cigarette smoke cessation model: Potential therapeutic target in reversing the damage caused by smoking?

Lebron, Isabella de Souza Lima; Silva, Ligia Furlan da; Paletta, Julia Tagliaferri; Silva, Rafael André da; Sant’Ana, Monielle; Costa, Sara de Souza; Iyomasa-Pilon, Melina Mizusaki; Souza, Helena Ribeiro; Possebon, Lucas; Girol, Ana Paula

doi:10.1016/j.prp.2019.152614

Cited by 3 publications

(1 citation statement)

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“…It is important to note that tumor markers can be altered by certain comorbidities. There are studies that show an association between specific comorbidities and IGFBP7 or ANXA1 [ 69 , 70 , 83 ]. As blood samples for our study were taken from all patients the day before surgery or panendoscopy as part of the standard preoperative examination, acute inflammatory processes or exacerbations of disease can be reliably excluded, as the patients would otherwise not have been applicable for the operation.…”

Section: Discussionmentioning

confidence: 99%

Exosomal Serum Biomarkers as Predictors for Laryngeal Carcinoma

Schuster,

Wendler,

Pesold

et al. 2024

Cancers

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Background: The lack of screening methods for LSCC is a critical issue, as treatment options and the treatment outcome greatly depend on the stage of LSCC at initial diagnosis. Therefore, the objective of this study was to identify potential exosomal serum biomarkers that can diagnose LSCC and distinguish between early- and late-stage disease. Methods: A multiplexed proteomic array was used to identify differentially expressed proteins in exosomes isolated from the serum samples of LSCC patients compared to the control group (septorhinoplasty, SRP). The most promising proteins for diagnosis and differentiation were calculated using biostatistical methods and were validated by immunohistochemistry (IHC), Western blots (WB), and ELISA. Results: Exosomal insulin-like growth factor binding protein 7 (IGFBP7) and Annexin A1 (ANXA1) were the most promising exosomal biomarkers for distinguishing between control and LSCC patients and also between different stages of LSCC (fold change up to 15.9, p < 0.001 for all). Conclusion: The identified proteins represent potentially novel non-invasive biomarkers. However, these results need to be validated in larger cohorts with a long-term follow-up. Exosomal biomarkers show a superior signal-to-noise ratio compared to whole serum and may therefore be an important tool for non-invasive biomarker profiling for laryngeal carcinoma in the future.

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Section: Discussionmentioning

confidence: 99%