Modulation of the Intestinal Ca<sup>2+</sup>Uptake by a Cheese Whey Protein Digest

Takano, Yoshihiko; Matsuura, Toshiki; Yoshikawa, Yukako; Satsu, Hideo; Sato, Ryuichiro; Shimizu, Makoto

doi:10.1271/bbb.60721

Cited by 12 publications

(9 citation statements)

References 28 publications

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“…Also, calcium uptake by specific transporters located on the IECs is regulated by diet compounds ( 61 ). For example, enhanced calcium uptake is observed with whey protein digest though the mechanism is not defined at all ( 62 ).…”

Section: Regulation Of the Intestinal Barrier Function By Nutritionalmentioning

confidence: 99%

Nutritional Keys for Intestinal Barrier Modulation

et al. 2015

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The intestinal tract represents the largest interface between the external environment and the human body. Nutrient uptake mostly happens in the intestinal tract, where the epithelial surface is constantly exposed to dietary antigens. Since inflammatory response toward these antigens may be deleterious for the host, a plethora of protective mechanisms take place to avoid or attenuate local damage. For instance, the intestinal barrier is able to elicit a dynamic response that either promotes or impairs luminal antigens adhesion and crossing. Regulation of intestinal barrier is crucial to control intestinal permeability whose increase is associated with chronic inflammatory conditions. The cross talk among bacteria, immune, and dietary factors is able to modulate the mucosal barrier function, as well as the intestinal permeability. Several nutritional products have recently been proposed as regulators of the epithelial barrier, even if their effects are in part contradictory. At the same time, the metabolic function of the microbiota generates new products with different effects based on the dietary content. Besides conventional treatments, novel therapies based on complementary nutrients are now growing. Fecal therapy has been recently used for the clinical treatment of refractory Clostridium difficile infection instead of the classical antibiotic therapy. In the present review, we will outline the epithelial response to nutritional components derived from dietary intake and microbial fermentation focusing on the consequent effects on the integrity of the epithelial barrier.

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Section: Regulation Of the Intestinal Barrier Function By Nutritionalmentioning

confidence: 99%

Nutritional Keys for Intestinal Barrier Modulation

et al. 2015

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“…CaT1(TRPV6) is known to be a calcium transporter responsible for the uptake of calcium by IECs. Takano et al 50) observed that a whey protein digest enhanced calcium uptake by IECs, although the mechanisms have not yet be determined.…”

Section: Modulation Of Transporter Functionsmentioning

confidence: 99%

Interaction between Food Substances and the Intestinal Epithelium

Shimizu

2010

Bioscience, Biotechnology, and Biochemistry

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130

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The small intestine is an organ responsible for nutrient absorption, barrier functions, signal recognition/transduction, and the production of bioactive compounds. These functions are known to be regulated by such factors as hormones and cytokines, but substances contained in the daily diet are also thought to play roles as major modulators of intestinal functions. Intestinal epithelial cells (IECs), which form a monolayer covering the inside surface of the intestinal tract, are particularly important in this modulation, because they directly interact with intestinal contents, including food substances, their digests, and gut microbial components. Using cell-based in vitro assays, we investigated the food-IEC interactions at the cellular and molecular levels, and found that a variety of food substances affected the transporter activity, tight junction permeability, metabolic enzyme expression, immune functions, and so on. Modulation of the intestinal functions by dietary substances is therefore essential to promote health.

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“…CPP-calcium complexes, for example, have been shown to keep Ca soluble at luminal pH, and subsequently promote calcium absorption. 18,19 To date, peptides from various sources, including casein, 19,20 phosvitin, 21 soy protein, 22 desalted duck egg white, 23 cheese whey protein 24 and fish-bone, 25 have been reported to exhibit calcium-binding capacity and enhance calcium absorption. However, investigation of the utilization of sea cucumber ovum hydrolysates as a source of calcium binding peptides has not been reported previously.…”

Section: Introductionmentioning

confidence: 99%