Modulation of transcallosally mediated motor inhibition in children with attention deficit hyperactivity disorder (ADHD) by medication with methylphenidate (MPH)

Buchmann, Johannes; Gierow, Wolfgang; Weber, S.; Hoeppner, Jacqueline; Klauer, Thomas; Wittstock, M.; Benecke, Reiner; Haessler, Frank; Wolters, Alexander

doi:10.1016/j.neulet.2006.06.026

Cited by 43 publications

(25 citation statements)

References 39 publications

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“…Concerning the RMT, no significant difference was found between ADHD and the healthy subjects in previous studies (13,14,16,17,42). Consistent with earlier studies (9,1013,17,18,19), no significant difference was detected in the RMT between before and after administration of MPH medication in ADHD subjects in this study. In contrast to MPH that chiefly affects dopamine and norepinephrine, drugs which block voltage gated sodium channels increase the RMT (43)(44)(45)(46), whereas ketamine that may indirectly increase neurotransmission through the AMPA receptor decreases it (8,47).…”

Section: Discussionsupporting

confidence: 89%

“…No significant differences in the RMT were found between ADHD and healthy subjects in previous studies (13)(14)(15)(16)(17). In addition, MPH treatment did not affect the RMT in ADHD patients (9,10,13,17,18,19).…”

Section: Discussionmentioning

confidence: 55%

“…However, other studies did not find differences in the CMCT between healthy children and children with ADHD (16,17,19). MPH did not alter the CMCT in ADHD children (16,19).…”

Section: Discussionmentioning

confidence: 74%

“…Uclés et al suggested that increased CMCT in ADHD could be related to delay in the maturation of cortico-motoneuronal system (21). However, no difference was found in the CMCT between normal and ADHD subjects in some previous studies (16,17,19). Administration of MPH did not change CMCT in children with ADHD in earlier studies (16,19).…”

Section: Discussionmentioning

confidence: 76%

See 3 more Smart Citations

The Effects of Methylphenidate on Transcranial Magnetic Stimulation Parameters in Children with Attention Deficit Hyperactivity Disorder

Ozdag

Yorbık

Durukan

et al. 2010

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 55%

“…However, other studies did not find differences in the CMCT between healthy children and children with ADHD (16,17,19). MPH did not alter the CMCT in ADHD children (16,19).…”

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 76%

See 2 more Smart Citations

The Effects of Methylphenidate on Transcranial Magnetic Stimulation Parameters in Children with Attention Deficit Hyperactivity Disorder

Ozdag

Yorbık

Durukan

et al. 2010

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…Although early clinical trials showed clinical responses to methylphenidate and ATX appeared to be equivalent , more recent studies comparing ATX to long-acting stimulants (Gibson et al, 2006) as well as clinical experience suggest ATX induces much more variable clinical responses and may differ in other important ways. It would also be of interest to compare ATX effects on other measures, such as transcallosal inhibition, with those of psychostimulants (Buchmann et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Atomoxetine treatment of ADHD in Tourette Syndrome: Reduction in motor cortex inhibition correlates with clinical improvement

Gilbert

Zhang

Lipps

et al. 2007

Clinical Neurophysiology

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Objective: In children with Attention Deficit Hyperactivity Disorder (ADHD), clinical responses to the selective norepinephrine reuptake inhibitor atomoxetine (ATX) vary. We sought to determine in children with Tourette Syndrome (TS) whether clinical responses correlate with changes in short interval cortical inhibition (SICI). Methods:Fourteen children, ages 8 to 16, with ADHD and TS were treated open-label with ATX for one month. ADHD rating scale scores and SICI, measured with paired-pulse Transcranial Magnetic Stimulation (pTMS), were assessed blindly and independently at treatment onset and one month later.Results: Eleven children, mean ADHD Rating Scale scores 31.8 (SD 8.2) at onset completed the study. After one month, ADHDRS changes ranged from an increase of 4 points to a decrease (improvement) of 24 points (mean change -9.6, SD 9.1). The changes in ADHDRS scores correlated with reduction in SICI (r = .74, p = .010). Conclusions:In children with TS, one month of atomoxetine treatment appears to induce correlated improvements in ADHD and, paradoxically, further reductions in cortical inhibition.Significance: PTMS-evoked SICI in ADHD with TS may be a biomarker of both deficiency and compensatory changes within cortical interneuronal systems. Effective atomoxetine treatment may augment compensatory processes and thereby reduce SICI.

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Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies

Storebø

Pedersen

Ramstad

et al. 2018

Cochrane Database of Systematic Reviews

244

161

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Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate. Our certainty in the evidence is very low, and accordingly, it is not possible to accurately estimate the actual risk of adverse events. It might be higher than reported here.Given the possible association between methylphenidate and the adverse events identified, it may be important to identify people who are most susceptible to adverse events. To do this we must undertake large-scale, high-quality RCTs, along with studies aimed at identifying responders and non-responders.

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Modulation of transcallosally mediated motor inhibition in children with attention deficit hyperactivity disorder (ADHD) by medication with methylphenidate (MPH)

Cited by 43 publications

References 39 publications

The Effects of Methylphenidate on Transcranial Magnetic Stimulation Parameters in Children with Attention Deficit Hyperactivity Disorder

The Effects of Methylphenidate on Transcranial Magnetic Stimulation Parameters in Children with Attention Deficit Hyperactivity Disorder

Atomoxetine treatment of ADHD in Tourette Syndrome: Reduction in motor cortex inhibition correlates with clinical improvement

Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies

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