Modulation of tumor necrosis factor-stimulated gene-6 (TSG-6) expression in human endometrium

Capp, Edison; Milner, Caroline M.; Williams, J.; Hauck, Lena; Jauckus, Julia; Strowitzki, T.; Germeyer, Ariane

doi:10.1007/s00404-013-3080-9

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…37 TNFAIP6 protein is a secreted protein which belongs to a member of the hyaluronic acid-binding protein family, and it may be related to the stability of extracellular matrix and cell migration. 38,39 Physiological Functions and Mechanisms of TNFAIP6 TSG-6 is believed to be an inflammatory protein associated with accelerated wound healing and reduced tissue fibrosis, and it can regulate chemokines by inhibiting the interaction of chemokines and mucopolysaccharides. 40,41 In rheumatoid arthritis and osteoarthritis, a study found that TSG-6 was high expression in patients' joints, suggesting that TSG-6 might be a proinflammatory medium.…”

Section: Tnfaip6 Basic Characteristics Of Tnfaip6mentioning

confidence: 99%

“…40 In vitro studies found that TSG-6 interacted with protein ligands and different mucopolysaccharides, and it could inhibit neutrophilic migration. 39 In addition, TSG-6 could inhibit the transmigration of neutrophils stimulated by chemokines through direct interaction between TSG-6 and CXCL8 binding site. At the same time, TSG-6 might impair the binding of CXCL8 to cell surface mucopolysaccharide, as well as the transport of CXCL8 in endothelial cells.…”

Section: Tnfaip6 Basic Characteristics Of Tnfaip6mentioning

confidence: 99%

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<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

Guo¹,

Yuan²

2020

OTT

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Tumor necrosis factor (TNF) is the first cytokine used in tumor biotherapy, but TNFrelated drugs are limited by the lack of specific targets. Tumor necrosis factor alpha-induced proteins (TNFAIPs), derived from TNF, is a protein family and participates in proliferation, invasion and metastasis of tumor cells. In order to better understand biological functions and potential roles of TNFAIPs in malignant tumors, this paper in the form of "Gene-Protein-Tumor correlation" summarizes the biological characteristics, physiological functions and mechanisms of TNFAIPs by searching National Center of Biotechnology Information, GeneCards, UniProt and STRING databases. The relationship between TNFAIPs and malignant tumors is analyzed, and protein-protein interaction diagram in members of TNFAIPs is drawn based on TNF for the first time. We find that TNF as a key factor is related to TNFAIP1, TNFAIP3, TNFAIP5, TNFAIP6, TNFAIP8 and TNFAIP9, which can be directly involved in activating TNFAIP1, TNFAIP5, TNFAIP8 and TNFAIP9. We confirm that the mechanism of TNFAIP1, TNFAIP2 and TNFAIP3 inducing tumors may be related to NF-κB signaling pathway, but the mechanism of tumor induction by other members of TNFAIPs is not clear. In the future, translational studies are needed to explore the mechanisms of TNF-TNFAIPs-tumors.

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Section: Tnfaip6 Basic Characteristics Of Tnfaip6mentioning

confidence: 99%

Section: Tnfaip6 Basic Characteristics Of Tnfaip6mentioning

confidence: 99%

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

Guo¹,

Yuan²

2020

OTT

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“…TSG6 is released from neutrophils, mast cells, macrophages, and stromal cells, and it displays antiinflammatory and tissue-protective properties (Day and Milner, 2019). These include inhibition of neutrophil migration, polarization of macrophages to an anti-inflammatory M2 phenotype, and modulation of endometrial matrix turnover and organization (Capp et al, 2014;Day and Milner, 2019). The present results lead to the hypothesis that underexpression of TSG6 in ST cells of persistent cows may be a relevant marker for the persistence of endometrial inflammation or a putative therapeutic target.…”

Section: Endometrial Health Status and Genes Related To Immune Responsementioning

confidence: 54%

Subclinical endometritis differentially affects the transcriptomic profiles of endometrial glandular, luminal, and stromal cells of postpartum dairy cows

Pereira

Guo

Silva

et al. 2022

Journal of Dairy Science

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In postpartum dairy cows, subclinical endometritis (SCE) is characterized by persistent endometrial inflammation, which has profound detrimental effects on subsequent reproductive performance. To date, transcriptomic studies related to this condition were either based on biopsy-derived whole-endometrium tissue or endometrial swab or cytobrush samples, thus masking effects of disease on cell type-specific gene expression. This study tested the hypothesis that different endometrial health statuses are associated with distinct transcription profiles of endometrial stromal, glandular, and luminal epithelial cells. At 44 d postpartum (DPP), endometrial biopsies were taken from dairy cows (n = 24) classified as healthy, recovered from SCE, or affected by persistent SCE, according to endometrial cytology taken at 21 and 44 DPP. Stromal, glandular, and luminal epithelial cells were isolated from the whole-tissue biopsy by laser capture microdissection, and the cell-specific transcription profiles were determined by RNA sequencing. Differential gene expression was analyzed with DESeq2 (https: / / bioconductor .org/ packages/ release/ bioc/ html/ DESeq2 .html).Results demonstrated that global transcriptomic profiles and corresponding lists of differentially expressed genes between cows with different health statuses were distinct among cell types. Results also showed that although healthy and recovered cows presented similar endometrial clinically healthy phenotypes at 44 DPP, the prior presence of immune cells still affected the transcriptome of endometrial cells at this stage, delaying complete functional recovery. Recovery or persistence of inflammation was associated with gene expression patterns involved not only in immune function but also in tissue remodeling, cell adhesion, and uterine receptivity in a cell type-specific manner. Identifying these signatures may contribute to the development of novel diagnostic tools and therapeutic strategies. In addition, these results may help to define preventive measures or ways to stimulate recovery from endometrial inflammation, thus helping to restore the fertility of postpartum dairy cows.

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“…During MeV infection, viral P protein activates the expression of the ubiquitin modifier TNFAIP3, which interacts with TRAF6-binding protein, TAX1BP1, forming a complex that acts as TRAF6 inhibitor by preventing E3 ligase TRAF6 polyubiquitination [ 63 ], thus blocking the TLR4-mediated proinflammatory signaling [ 63 ]. The second member of the family found to be overexpressed in our study is TNFAIP6, known as TSG-6, a secreted multifunctional protein, produced at sites of inflammation, which acts as mediator of tissue remodeling and anti-inflammatory responses, mainly by regulating chemokines [ 61 , 64 , 65 ]. Human TNFAIP6 has a Link module (Link_TSG6) which binds to CXC- and CC-chemokines inhibiting neutrophile migration and their influx to inflammatory sites [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Dual RNA-Seq Enables Full-Genome Assembly of Measles Virus and Characterization of Host–Pathogen Interactions

et al. 2021

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Measles virus (MeV) has a negative-sense 15 kb long RNA genome, which is generally conserved. Recent advances in high-throughput sequencing (HTS) and Dual RNA-seq allow the analysis of viral RNA genomes and the discovery of viral infection biomarkers, via the simultaneous characterization of the host transcriptome. However, these host–pathogen interactions remain largely unexplored in MeV infections. We performed untargeted Dual RNA-seq in 6 pharyngeal and 6 peripheral blood mononuclear cell (PBMCs) specimens from patients with MeV infection, as confirmed via routine real-time PCR testing. Following optimised DNase treatment of total nucleic acids, we used the pharyngeal samples to build poly-A-enriched NGS libraries. We reconstructed the viral genomes using the pharyngeal datasets and we further conducted differential expression, gene-ontology and pathways enrichment analysis to compare both the pharyngeal and the peripheral blood transcriptomes of the MeV-infected patients vs. control groups of healthy individuals. We obtained 6 MeV genotype-B3 full-genome sequences. We minutely analyzed the transcriptome of the MeV-infected pharyngeal epithelium, detecting all known viral infection biomarkers, but also revealing a functional cluster of local antiviral and inflammatory immune responses, which differ substantially from those observed in the PBMCs transcriptome. The application of Dual RNA-seq technologies in MeV-infected patients can potentially provide valuable information on the virus genome structure and the cellular innate immune responses and drive the discovery of new targets for antiviral therapy.

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Modulation of tumor necrosis factor-stimulated gene-6 (TSG-6) expression in human endometrium

Abstract: These data suggest that TSG-6 expression might be essential in endometrial matrix organization and feto-maternal communication during the implantation process.

Cited by 7 publications

References 38 publications

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

Subclinical endometritis differentially affects the transcriptomic profiles of endometrial glandular, luminal, and stromal cells of postpartum dairy cows

Dual RNA-Seq Enables Full-Genome Assembly of Measles Virus and Characterization of Host–Pathogen Interactions

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