Modulations of Cytokine Expression in Pregnant Women

Tranchot-Diallo, Juliette; Gras, Gabriel; Parnet-Mathieu, F; Benveniste, Olivier; Marcé, Domíníque; Roques, Pierre; Milliez, Jacques; Chaouat, Gérard; Dormont, Dominique

doi:10.1111/j.1600-0897.1997.tb00218.x

Cited by 78 publications

(49 citation statements)

References 43 publications

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“…Although pregnant women included for our study had no contractions, the spontaneous production of IL-6 by peripheral lymphocytes was quite high. It does not confirm the observations of Tranchot-Diallo et al [10] who stated that IL-6 mRNA levels in peripheral blood mononuclear cells were depressed from the first trimester until the day of parturition. Because basal peripheral blood lymphocytes IL-6 secretion is so high, it probably means that rapidly increasing serum IL-6 concentrations in labor do not originate from activated peripheral blood lymphocytes.…”

Section: Discussioncontrasting

confidence: 55%

‘In vitro’ Cytokine Secretion by Peripheral Blood and Decidual Lymphocytes during the Third Trimester of Normal Pregnancy

Wilczyński

Tchórzewski²,

Głowacka³

et al. 2003

Gynecol Obstet Invest

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If the ‘Th2 phenomenon’ is dependent on trophoblastic antigens and cytokines, the profile of cytokines secreted by decidual lymphocytes (DL) should indicate stronger Th2 shift than that of peripheral blood lymphocytes (PBL). We studied spontaneous and mitogen-stimulated ‘in vitro’ cytokine secretion of cultured lymphocytes isolated from peripheral blood (n = 21) and decidua (n = 11) of third trimester healthy pregnant women not being in labor. The ELISA method was used for estimation of IL-2, IL-4, IL-6, IL-10, IL-12, IFN-γ and TGF-β. The results (given in pg/ml) were found to be statistically significant in the Mann-Whitney U-test (p < 0.05). Compared to PBL, DL produced spontaneously decreased concentrations of IL-12, IL-6, IFN-γ and TGF-β and upon mitogen stimulation increased quantities of IL-2, IL-4 and IL-10. It demonstrates that DL play an active role in local Th2-like immunoregulation and that their cytokine secretion pattern estimated in ‘in vitro’ conditions is biased towards Th2 activity more than that of PBL.

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Section: Discussioncontrasting

confidence: 55%

‘In vitro’ Cytokine Secretion by Peripheral Blood and Decidual Lymphocytes during the Third Trimester of Normal Pregnancy

Wilczyński

Tchórzewski²,

Głowacka³

et al. 2003

Gynecol Obstet Invest

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“…9,15 It could also depend whether control sample was taken from pregnant women at term, during labour5 or in a non pregnant women or in first trimester of pregnancy. 7 As a result of intercellular communication, changes of expression of types and qualities of cytokines occur.…”

Section: Discussionmentioning

confidence: 99%

Study of TH 1 and TH 2 activity in women with threatened miscarriages

Jain

Hassan

Jain

2015

Int J Reprod Contracept Obstet Gynecol

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“…Early placental implantation is alsocharacterized by a cytokine -and humoral-mediated antiinflammatory T-helper cell type (Th) 2-dominated environment which is thought to induce local immunosuppression to the allogeneic fetus and placenta. Consistently, classical Th2 cytokines such as interleukin (IL)-4 and IL-10 are upregulated in the serum of pregnant women [24] as well as at the fetalmaternal interface [25] and were shown to regulate trophoblast invasion [26,27]. Moreover, it is suggested that an overall shift towards proinflammatory Th1 predominance may cause adverse pregnancy outcome such as spontaneous abortion, premature delivery, preeclampsia and intrauterine growth restriction (IUGR) [28].…”

Section: Introductionmentioning

confidence: 98%

Die Rolle des invasiven, plazentaren Trophoblasten in der Schwangerschaft

Pollheimer

Knöfler

2012

Wien Med Wochenschr

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During early pregnancy the placenta-derived extravillous trophoblast starts to invade the maternal uterus in order to regulate adequate blood flow and nutrient supply to the growing fetus. A unique set of events including plugging and remodelling of maternal vessels, regulation of oxygen levels, as well as the crosstalk with maternal decidual cells are thought to be precisely controlled by the invading extravillous trophoblasts. However, defects in these processes can lead to severe complications during pregnancy threatening the well-being of both the mother and the developing fetus. For instance incomplete trophoblast-associated invasion and arterial remodelling are associated with preeclampsia, the most common pregnancy-related complication. Moreover, failure in proper placental development and adequate fetal nutrition could be effective later in life, as growth-restricted neonates have a higher risk to develop adult onset of hypertension, heart disease and diabetes mellitus. Consequently, a detailed understanding of the mechanisms that underlie trophoblast invasion is thought to improve both diagnosis and treatment of various pregnancy-related disorders.

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Modulations of Cytokine Expression in Pregnant Women

Abstract: Cytokine expression is thus finely tuned in peripheral blood during pregnancy, in a previously unexpected complex pattern, related to gestational stage.

Cited by 78 publications

References 43 publications

‘In vitro’ Cytokine Secretion by Peripheral Blood and Decidual Lymphocytes during the Third Trimester of Normal Pregnancy

‘In vitro’ Cytokine Secretion by Peripheral Blood and Decidual Lymphocytes during the Third Trimester of Normal Pregnancy

Study of TH 1 and TH 2 activity in women with threatened miscarriages

Die Rolle des invasiven, plazentaren Trophoblasten in der Schwangerschaft

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