Modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters

Abstract

Background Newly, chemo‐preventive technique might be a hopeful advancement in developing countries for treating cancers with the aid of toxic less natural based constituents. Malignancy urges to augment effectual chemo‐preventive agents that are look forward to suppress the tumours which may be stimulated by chewing and smoking of tobacco and over alcohol consumption related with the high prevalence of human oral cancer (OC) patients. Methods In the present research, we examined to assess antioxidants, lipid peroxidation (LPO) and detoxification enzymes levels of anticancer activity of mangiferin on 0.5% 7.12‐dimethylbenz[a]anthracene (DMBA) provoked hamster cheek pouch carcinoma (HCPC). OC on hamster buccal pouch (HBP) was incited by DMBA treatment for thrice per week for over 14 weeks. Results 100% well defined OC establishment with body weight (bw), tumour burden (TB), antioxidant, LPO and liver marker enzymes and also histological changes were observed on DMBA‐challenged buccal pouch carcinoma (BPC) in hamsters. Orally treated mangiferin at an effective dosage of 50 mg/kg bw, to DMBA painted hamsters were significantly averted the body weight, succession of tumour, the biochemical as well as histopathological changes. Conclusion Findings of this work clearly suggest that the anti‐carcinoma effect of mangiferin possesses the modulator effects on potent antioxidant, anti‐LPO and detoxification agents to expel the metabolites of malignant cells, on DMBA‐provoked BPC in hamsters.

Therapeutic potential of mangiferin in cancer: Unveiling regulatory pathways, mechanisms of action, and bioavailability enhancements – An updated review

“…The first origin of MGF was Anemarrhena asphodeloides Bunge, which was greatly used in traditional Chinese medicine to treat neuropathy caused by diabetes (Jabeen et al., 2023 ; Lin et al., 2020 ). The major plant source of MGF is Mangifera indica (Family: Anacardiaceae ), commonly named as mango tree; fruit shells, stem, greenery, bark, roots, and seed (Aboyewa et al., 2021 ; Liu et al., 2021 ; Rodriguez‐Gonzalez et al., 2021 ; Yadav et al., 2022 ) and also found in a few other medicinal herbs and families like Salacia Chinensis ( roots ) (Zeng et al., 2020 ), Swertia chirata , Hypericum aucheri , Cyclopia intermedia (Aboyewa et al., 2021 ; Rodriguez‐Gonzalez et al., 2021 ), Anacardiaceae , Celastraceae , Gentianaceae families (Zeng et al., 2020 ), Zingiberaceae , Aphloiaceae Cnidii Rhizoma , Angelica Sinensis , and Levisticum officinale (Grauzdytė et al., 2019 ) an Aquilaria crassna (agarwood) (Thitikornpong et al., 2019 ) and honeybush tea (Chen et al., 2022 ; Zhang & Wang, 2018 ).…”

“…Several studies have been conducted in recent years employing the fruit's various components: peel, pulp, seed, and phytochemicals (Lo Galbo et al., 2021 ). Various studies show that MGF possesses some antioxidant actions, a role in treating obesity, the therapeutic potential for osteoarthritis (Aboyewa et al., 2021 ) protection of the gastrointestinal tract, an antidiabetic role, and in vitro repressing properties on type‐II 5α‐reductase, modulatory response in the immune system, that is, maybe suppressive or stimulative, hepatoprotective, and cardioprotective effects in various diseases in rodents (Khoobchandani et al., 2021 ; Liu et al., 2021 ; Mubashir et al., 2022 ; Xiao et al., 2021 ). It also shows photoprotective, analgesic, neuroprotective, anti‐Alzheimer (Grauzdytė et al., 2019 ), and anti‐allergic potential (Meng et al., 2023 ; Thitikornpong et al., 2019 ).…”

“…Various studies show that MGF possesses some antioxidant actions, a role in treating obesity, the therapeutic potential for osteoarthritis (Aboyewa et al, 2021) protection of the gastrointestinal tract, an antidiabetic role, and in vitro repressing properties on type-II 5α-reductase, modulatory response in the immune system, that is, maybe suppressive or stimulative, hepatoprotective, and cardioprotective effects in various diseases in rodents (Khoobchandani et al, 2021;Liu et al, 2021;Mubashir et al, 2022;Xiao et al, 2021).…”

“…Chemoprevention is a new treatment that involves suppressing malignant development using natural herbal-based substances (Liu et al, 2021).…”

“…812 genes were downregulated at 100 mg/kg body weight MGF dose with minor transcriptional changes in mitochondrial metabolic strain, iron maintenance, fatty acid metabolism, peroxisome proliferator-activated receptors, and regulators of lipid metabolism (PPARs), Glycoprotein 6 (GP6) signaling pathways and nuclear factor kappa B (NFkB) cause a decrease in movement (invasion) of the tumor and new blood vessels formation around tumor cells. MGF promotes decreased intra-tumoral and pre-tumoral blood supply levels (81% reduction at 200 μg/mL), and tumor volume and weight reduced by 84 and 73% at 200 μg/mL dose of MGF (Rodriguez-Gonzalez et al, 2021).Oral cancer is a malignant condition that includes head and neck carcinoma (HNC)(Liu et al, 2021); more than six lakh people have mouth cancer worldwide, and three lakhs die due to its severity. Risk factors for oral cancers are chewing betel nuts(Hung et al, 2020), overconsumption of tobacco, alcohol, and smoking.…”