Modulatory effect of butyric acid—a product of dietary fiber fermentation in experimentally induced diabetic rats

Kumar, C. Mohan; Rachappaji, K S; Nandini, C.; Sambaiah, K.; Salimath, Paramahans V.

doi:10.1016/s0955-2863(02)00180-8

Cited by 26 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these, butyric acid [33], trans -palmitoleic acid [34] and phytanic acid [35] have been shown to have antidiabetic properties. Phytanic acid, a product of ruminal degradation of chlorophyll, induces brown adipocyte differentiation, and induces the uncoupling protein in brown adipocytes, leading to increased thermogenesis [35].…”

Section: Sfamentioning

confidence: 99%

Saturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular Risk

2017

View full text Add to dashboard Cite

Dietary recommendations to decrease the risk of cardiovascular disease (CVD) have focused on reducing intake of saturated fatty acids (SFA) for more than 50 years. While the 2015–2020 Dietary Guidelines for Americans advise substituting both monounsaturated and polyunsaturated fatty acids for SFA, evidence supports other nutrient substitutions that will also reduce CVD risk. For example, replacing SFA with whole grains, but not refined carbohydrates, reduces CVD risk. Replacing SFA with protein, especially plant protein, may also reduce CVD risk. While dairy fat (milk, cheese) is associated with a slightly lower CVD risk compared to meat, dairy fat results in a significantly greater CVD risk relative to unsaturated fatty acids. As research continues, we will refine our understanding of dietary patterns associated with lower CVD risk.

show abstract

Section: Sfamentioning

confidence: 99%

Saturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular Risk

2017

View full text Add to dashboard Cite

show abstract

“…Our earlier studies on n-butyrate had shown the importance of fibres on the activity of intestinal disaccharidases which further facilitated slow absorption of glucose [11,48]. …”

Section: Discussionmentioning

confidence: 99%

“…After they escape digestion in the small intestine, they enter the large intestine, where they become substrate for the intestinal microflora that can degrade many of the non-starch polysaccharides into short chain fatty acids (SCFA) [10]. Beneficial effects of SCFA are well documented [11]. Although, dietary fiber treatment is known to maintain blood glucose level [12], their beneficial effects on diabetic complications particularly nephropathy is not well addressed.…”

Section: Introductionmentioning

confidence: 99%

Effect of spent turmeric on kidney glycoconjugates in streptozotocin-induced diabetic rats

Kumar

Salimath

2014

J Diabetes Metab Disord

View full text Add to dashboard Cite

BackgroundCurcumin known to have number of medicinal use and masked the fiber containing ukonan like active polysaccharide in turmeric and its pharmacological effect will be addressed on diabetic nephropathy particularly the glycoconjugates of extracellular components viz., glycoproteins and glycosaminoglycans - heparan sulfate (HS).MethodsMale Wistar rats were maintained on AIN-76 diet containing 10% spent turmeric and were grouped into control and STZ induced diabetes SFC/TFC and SFD/TFD, respectively. Diabetic status was monitored using blood and urine, and at the end, harvested kidneys were used to study the amelioration of glycoprotiens (collagen) and HS by enzymatic digestion, spectrophotometric, hydroxyproline and agarose electrophoretic methods.ResultsIn the present study spent turmeric (10%) fed diabetic rats showed improved glomerular filtration rate (50%), kidney enlargement (60%) and other glycoconjugate metabolism in kidney. Increased collagen content in diabetic group was observed by hydroxyproline estimation (24%) and periodic acid-Schiff’s (PAS) staining. Furthermore, elevated activities of enzymes involved in the synthesis and degradation of glycosaminoglycans (GAGs) were significantly lowered in spent turmeric fed diabetic group. Improvement in total GAGs (43%) and sulfate content (18%) followed by fractionation of GAGs using specific enzymes led to HS (28%) in the spent turmeric fed diabetic group, when compared to starch fed diabetic group and was further confirmed by electrophoresis of GAG.ConclusionThese results clearly indicate beneficial role of spent turmeric in controlling glycoconjugates such as glycoproteins and heparan sulfate related kidney complications during diabetes.

show abstract

“…Various dietary components, such as wheat bran and guar gum, butyric acid, the product obtained by anaerobic digestion of dietary fiber, fenugreek, and spent turmeric, have been shown to ameliorate the diabetic condition to various extents, imparting beneficial effects on the kidney. [7][8][9] Coccinia indica (synonym C. cordifolia) belongs to the Cucurbitaceae family and grows abundantly in India. It is a climbing perennial herb, growing throughout India especially in warmer and humid climatic conditions.…”

Section: Introduction Dmentioning

confidence: 99%

Renoprotective Effect ofCoccinia indicaFruits and Leaves in Experimentally Induced Diabetic Rats

Gurukar

Mahadevamma

Chilkunda

2013

Journal of Medicinal Food

View full text Add to dashboard Cite

Diabetic nephropathy is one of the secondary complications of diabetes mellitus that is marked by changes in extracellular matrix components leading to end-stage renal failure. Diet plays an important role in managing diabetes. In the present study, the effect of Coccinia indica consumption on diabetes-mediated kidney damage was determined. Both control and diabetic rats were fed with AIN-76 diet supplemented with C. indica fruits and leaves individually at 10% and 5%, respectively, for a period of 2 months. Various parameters, such as fasting blood glucose, urine sugar, albumin excretion, kidney index, and glomerular filtration rate, were ameliorated to various extents by the supplementation of C. indica in the diet. Additionally, diabetic rats fed with diet supplemented with C. indica fruits or leaves showed improvement in glucose tolerance compared to control diabetic rats. They also exhibited beneficial effects on key antioxidant enzymes of the kidney. Furthermore, an increase in laminin and fibronectin as a result of diabetes was alleviated in C. indica-fed rats. These results indicate that the consumption of C. indica is beneficial in partially containing diabetes-mediated deleterious effects on the kidney.

show abstract

Modulatory effect of butyric acid—a product of dietary fiber fermentation in experimentally induced diabetic rats

Cited by 26 publications

References 21 publications

Saturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular Risk

Saturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular Risk

Effect of spent turmeric on kidney glycoconjugates in streptozotocin-induced diabetic rats

Renoprotective Effect ofCoccinia indicaFruits and Leaves in Experimentally Induced Diabetic Rats

Contact Info

Product

Resources

About