Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats

Ali, Shimaa O.; Darwish, Hebatallah A.; Ismail, Nabila A.

doi:10.1016/j.cbi.2014.03.009

Cited by 45 publications

(23 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TAA causes an elevation of oxidative stress, enhancing free radical mediated damage to proteins, lipids and DNA (Brucket al, 2004;Tunez et al, 2005;Uskokovic-Markovic et al, 2007). Several studies have demonstrated the beneficial effect of antioxidants against TAA toxicity (UskokovicMarkovic et al, 2007;Baskaran et al, 2010;Mustafa et al, 2013;Ali et al, 2014). Olive leaves are a source of several antioxidants (Briante et al, 2002;Bouaziz and Sayadi, 2005;Meirinhos et al, 2005;Ranalli et al, 2006).…”

Section: Discussionmentioning

confidence: 96%

Physiological investigations on the effect of olive and rosemary leaves extracts in male rats exposed to thioacetamide

Al-Attar

Shawush

2014

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Physiologically, it is known that thioacetamide (TAA) toxicity is generally associated with hepatic fibrosis induction, complicated metabolic disorders and health problems. The capability of extracts of olive and rosemary leaves to attenuate the severe physiological disturbances induced by thioacetamide (TAA) intoxication in male rats has been evaluated. Healthy male Wistar rats were used in the present study and were divided randomly into eight groups. Rats of the first group were served as normal control. Rats of the second group were administrated with TAA. Rats of the third, fourth and fifth groups were exposed to TAA plus olive leaves extract, TAA plus rosemary leaves extract and TAA plus olive and rosemary leaves extracts respectively. The sixth, seventh and eighth groups were supplemented with olive leaves extract, rosemary leaves extract, and olive and rosemary leaves extracts respectively. After 12 weeks of experimental treatments, the levels of serum glucose, total protein, albumin and high density lipoprotein cholesterol were significantly decreased, while the levels of triglycerides, cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, creatine kinase and lactate dehydrogenase were statistically increased in rats exposed to TAA. Administration of the studied extracts inhibited the hematobiochemical parameters and improved the physiological disturbances induced by TAA intoxication. Additionally, most improvements were noted in rats administrated with rosemary leaves extract followed by olive and rosemary leaves extracts and olive leaves extract. These results suggested that the effect of these extracts might be due to their antioxidant activities against TAA toxicity.

show abstract

Section: Discussionmentioning

confidence: 96%

Physiological investigations on the effect of olive and rosemary leaves extracts in male rats exposed to thioacetamide

Al-Attar

Shawush

2014

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

show abstract

“…1) is derived from the milk thistle plant (Lee et al 2006) and has been used for centuries as a natural remedy in the treatment of hepatitis and cirrhosis (Stanca et al 2013;Ali et al 2014;Serviddio et al 2014), as well as in the protection of the liver from toxic substances (Tedesco et al 2004;Sersen et al 2006). SIL is also efficacious in preventing hepatic lipid peroxidation and ischemia (Lettéron et al 1990; Raza et al 2011).…”

Section: Introductionmentioning

confidence: 98%

Preparation and performance evaluation of emulsomes as a drug delivery system for silybin

Zhou

Chen

2015

Arch. Pharm. Res.

View full text Add to dashboard Cite

We developed silybin (SIL) emulsomes and evaluated their physicochemical properties and the in vivo pharmacokinetics of SIL delivered by emulsomes in rats. SIL emulsomes were prepared using the thin film dispersion method. SIL emulsomes were evaluated for their entrapment efficiency, particle size, zeta potential, morphology, in vitro release, and in vivo drug delivery in rats. The entrapment efficiency was above 80 %. The average particle size and zeta potential were 364.1 ± 20 nm and -34 ± 8 mV, respectively. Morphological analysis revealed that the SIL emulsomes were spherical in shape. Compared to an SIL solution, emulsomes produced sustained release of SIL for up to 48 h after an initial burst release in vitro. The pharmacokinetics of SIL emulsomes in rats were evaluated after intravenous injection, and the results were compared with those obtained for the control SIL solution. Following SIL delivery by emulsomes, the area under the curve was 2.2-fold higher and the mean residence time was 2.5-fold higher than the corresponding values recorded using SIL solution. Hence, emulsomes might represent a promising system for improving the bioavailability of lipophilic drugs. Moreover, emulsomes produce sustained drug release, which is advantageous in the clinical setting.

show abstract

“…Treatment schedule. One week after acclimatization, a large group of rats was given intraperitoneal doses of 200 mg TAA/kg body-weight, on alternative days, three times weekly for 4 weeks [30,31]. At the end of the induction period, a group of rats was killed to assess the development of chronic hepatitis (TAA) in comparison with their respective saline-treated control group.…”

Section: Methodsmentioning

confidence: 99%

Curcumin, Silybin Phytosome^® and α‐R‐Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production

Ali

Darwish

Ismail

2015

Basic Clin Pharma Tox

View full text Add to dashboard Cite

Chronic hepatitis is recognized as a worldwide health problem that gradually progresses towards cirrhosis and hepatocellular carcinoma. Despite the large number of experiments using animal models for allergic hepatitis, it is still difficult to produce a picture of chronic hepatitis. Therefore, this study was conducted to introduce an animal model approximating to the mechanism of chronicity in human hepatitis. The study also aimed to examine the hepatoprotective effects of curcumin, silybin phytosome â and a-R-lipoic acid against thioacetamide (TAA)-induced chronic hepatitis in rat model. TAA was administered intraperitoneally at a dose of 200 mg/kg three times weekly for 4 weeks. At the end of this period, a group of rats was killed to assess the development of chronic hepatitis in comparison with their respective control group. TAA administration was then discontinued, and the remaining animals were subsequently allocated into four groups. Group 1 was left untreated, whereas groups 2-4 were allowed to receive daily oral doses of curcumin, silybin phytosome â or a-R-lipoic acid, respectively, for 7 weeks. Increases in hepatic levels of malondialdehyde associated with TAA administration were inhibited in groups receiving supplements. Furthermore, glutathione depletion, collagen deposition, macrophage activation and nuclear factor jappa-B expression as well as tumour necrosis factor-a and interleukin-6 levels were significantly decreased in response to supplements administration. Serological analysis of liver function and liver histopathological examination reinforced the results. The above evidence collectively indicates that the antioxidant and anti-inflammatory activities of curcumin, silybin phytosome â and a-R-lipoic acid may confer therapeutic efficacy against chronic hepatitis.

show abstract

Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats

Cited by 45 publications

References 48 publications

Physiological investigations on the effect of olive and rosemary leaves extracts in male rats exposed to thioacetamide

Physiological investigations on the effect of olive and rosemary leaves extracts in male rats exposed to thioacetamide

Preparation and performance evaluation of emulsomes as a drug delivery system for silybin

Curcumin, Silybin Phytosome^® and α‐R‐Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production

Contact Info

Product

Resources

About

Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats

Cited by 45 publications

References 48 publications

Physiological investigations on the effect of olive and rosemary leaves extracts in male rats exposed to thioacetamide

Physiological investigations on the effect of olive and rosemary leaves extracts in male rats exposed to thioacetamide

Preparation and performance evaluation of emulsomes as a drug delivery system for silybin

Curcumin, Silybin Phytosome® and α‐R‐Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production

Contact Info

Product

Resources

About

Curcumin, Silybin Phytosome^® and α‐R‐Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production