Modulatory effects of miracle fruit ethanolic extracts on glucose uptake through the insulin signaling pathway in C2C12 mouse myotubes cells

Han, Yi‐Chun; Wu, Ju-Yu; Wang, Chin‐Kun

doi:10.1002/fsn3.935

Cited by 18 publications

(13 citation statements)

References 33 publications

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“…Methanolic extracts obtained from the leaves also demonstrated antidiabetic effects including insulin synthesis, a reduction in inflammation, and the modulation of carbohydrate-metabolizing enzymes [ 48 ]. Ethanolic extracts from the pulp were shown to increase the uptake of glucose through the upregulation of the GLUT4 transporter in C2C12 myocytes [ 43 ], reinforcing the idea that MB could control the circulating levels of glucose. More studies are required to identify the specific bioactive compounds responsible for these effects and to demonstrate the safety of these compounds in terms of hypoglycemia.…”

Section: Miracle Berrymentioning

confidence: 93%

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Miracle Berry as a Potential Supplement in the Control of Metabolic Risk Factors in Cancer

et al. 2020

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The increased incidence of chronic diseases related to altered metabolism has become a social and medical concern worldwide. Cancer is a chronic and multifactorial disease for which, together with genetic factors, environmental factors are crucial. According to the World Health Organization (WHO), up to one third of cancer-related deaths could be prevented by modifying risk factors associated with lifestyle, including diet and exercise. Obesity increases the risk of cancer due to the promotion of low-grade chronic inflammation and systemic metabolic oxidative stress. The effective control of metabolic parameters, for example, controlling glucose, lipid levels, and blood pressure, and maintaining a low grade of chronic inflammation and oxidative stress might represent a specific and mechanistic approach against cancer initiation and progression. Miracle berry (MB) (Synsepalum dulcificum) is an indigenous fruit whose small, ellipsoid, and bright red berries have been described to transform a sour taste into a sweet one. MB is rich in terpenoids, phenolic compounds, and flavonoids, which are responsible for their described antioxidant activities. Moreover, MB has been reported to ameliorate insulin resistance and inhibit cancer cell proliferation and malignant transformation in vitro. Herein, we briefly summarize the current knowledge of MB to provide a scientific basis for its potential use as a supplement in the management of chronic diseases related to altered metabolism, including obesity and insulin resistance, which are well-known risk factors in cancer. First, we introduce cancer as a metabolic disease, highlighting the impact of systemic metabolic alterations, such as obesity and insulin resistance, in cancer initiation and progression. Next, as oxidative stress is closely associated with metabolic stress, we also evaluate the effect of phytochemicals in managing oxidative stress and its relationship with cancer. Finally, we summarize the main biological activities described for MB-derived extracts with a special focus on the ability of miraculin to transform a sour taste into a sweet one through its interaction with the sweet taste receptors. The identification of sweet taste receptors at the gastrointestinal level, with effects on the secretion of enterohormones, may provide an additional tool for managing chronic diseases, including cancer.

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Section: Miracle Berrymentioning

confidence: 93%

“…Extracts in the presence of 95% ethanol from the skin and pulp also showed positive correlations between the total phenolic content and the in vitro antioxidant activities [ 43 ].…”

Section: Miracle Berrymentioning

confidence: 99%

Miracle Berry as a Potential Supplement in the Control of Metabolic Risk Factors in Cancer

et al. 2020

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“…Serum creatine kinase levels were measured by Creatine Kinase (CK) Colorimetric Assay Kit (BioVision, San Francisco, CA, USA ) according to the manufacturer's instruction that has been described previously (Han, Wu, & Wang, 2019). The method in tissue preparations for histopathology were adapted from Kiernan's method as described previously (Widhiantara et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Ethanolic extract of black grapes (Vitis Vinifera) ameliorates overtraining-induced pancreatic β-cells and muscle damage

Siswanto¹,

Pradhany

Yenniastoeti

et al. 2020

J. Riset Vet. Ind.

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Overtraining is a high-volume, high-intensity, long-duration, and high-frequency training. The heavier physical training, the more oxygen needed for metabolism. Increasing oxygen usage causes an elevation of electron leakage in mitochondria;thus,produce a higher amount of reactive oxygen species (ROS). Antioxidant inhibits oxidative damage in a target molecule. Grapes contain a lot of antioxidants, such as polyphenols and anthocyanins. The purpose of this study was to examine the effect of ethanol extract of Balinese grapes (Vitis vinifera) on β-cells and muscle damage in overtraining-induced rats. This study was a completely randomized experimental study using a posttest only control group design. Samples were 36 male albino rats (Rattus norvergicus), aged 2.5-3 months, divided randomly into two groups. The control group (P0), 18 rats, were given overtraining and placebo of 2 ml distilled water; the treatment group (P1) 18 rats, were given overtraining and 25g/kg.BW ethanol extract of Balinese grapes. The result showed the average amount of pancreatic β-cells in the P0 group was higher than the P1 group (p< 0.001). In addition, the average level of creatine kinase was also higher in the P1 group than those of the P0 group (p<0,001). It can be concluded that the administration of ethanolic extract of Balinese grapes mitigates the damage on pancreatic β-cells and muscle cells induced with overtraining.

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“…The leaf extract has the function such as presence of anti-hyperuric acid ( Shi, et al, 2016 ; Chen, et al, 2018 ), inhibition of oxidative damage, and anti-mutagenicity ( Chen, et al, 2015 ). Research on seeds has focused on cholesterol-lowering ( Huang, et al, 2020 ) and antidiabetic effects ( Han, et al, 2019 ). MFS oil has also been reported to treat breakage and damaged hair in women because of the phytochemicals and nutrients it contains ( Del Campo, et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease

Huang

Xue²,

Chen³

et al. 2023

Front. Pharmacol.

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Currently, the treatment of Alzheimer’s disease (AD) is still at the stage of symptomatic treatment due to lack of effective drugs. The research on miracle fruit seeds (MFSs) has focused on lipid-lowering and antidiabetic effects, but no therapeutic effects have been reported in AD. The purpose of this study was to provide data resources and a potential drug for treatment of AD. An AD mouse model was established and treated with MFSs for 1 month. The Morris water maze test was used to assess learning memory function in mice. Nissl staining was used to demonstrate histopathological changes. MFSs were found to have therapeutic implications in the AD mouse model, as evidenced by improved learning memory function and an increase in surviving neurons. To explore the mechanism of MFSs in treating AD, network pharmacological approaches, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and molecular docking studies were carried out. Based on the network pharmacology strategy, 74 components from MFS corresponded to 293 targets related to the AD pathology. Among these targets, AKT1, MAPK3, ESR1, PPARG, PTGS2, EGFR, PPARA, CNR1, ABCB1, and MAPT were identified as the core targets. According to the relevant number of core targets, cis-8-octadecenoic acid, cis-10-octadecenoic acid, 2-dodecenal, and tetradecane are likely to be highly correlated with MFS for AD. Enrichment analysis indicated the common targets mainly enriched in AD and the neurodegeneration-multiple disease signaling pathway. The molecular docking predictions showed that MFSs were stably bound to core targets, specifically AKT1, EGFR, ESR1, PPARA, and PPARG. MFSs may play a therapeutic role in AD by affecting the insulin signaling pathway and the Wnt pathway. The findings of this study provide potential possibilities and drug candidates for the treatment of AD.

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Modulatory effects of miracle fruit ethanolic extracts on glucose uptake through the insulin signaling pathway in C2C12 mouse myotubes cells

Cited by 18 publications

References 33 publications

Miracle Berry as a Potential Supplement in the Control of Metabolic Risk Factors in Cancer

Miracle Berry as a Potential Supplement in the Control of Metabolic Risk Factors in Cancer

Ethanolic extract of black grapes (Vitis Vinifera) ameliorates overtraining-induced pancreatic β-cells and muscle damage

Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease

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