Mogroside-Rich Extract From Siraitia grosvenorii Fruits Ameliorates High-Fat Diet-Induced Obesity Associated With the Modulation of Gut Microbiota in Mice

Abstract

Siraitia grosvenorii is a kind of medicinal food plant. The mogroside-rich extract (MGE) of its fruits can effectively ameliorate obesity, but the underlying mechanisms remain underexplored. In this study, we aimed to determine whether MGE can ameliorate obesity by protecting against the divergences of gut microbiota. Mice were challenged with a high-fat diet (HFD) and treated with MGE by oral gavage. Then, the characteristics of the gut microbiota were determined by 16S rDNA analysis. Our findings showed that MGE could significantly reduce body weight gain and fat tissue weight of the mice fed with HFD. Moreover, MGE markedly attenuated fatty liver, and improved glucose tolerance and insulin sensitivity. We further found that the gut microbiota structures were disturbed by HFD feeding. In particular, the abundance of Firmicutes was increased and the abundance of Bacteroidetes was decreased, resulting in an increased proportion of Firmicutes to Bacteroidetes (F/B), which contributes to obesity. Interestingly, the abnormal proportion of F/B of HFD feeding mice was restored to the level of control mice by MGE treatment. Additionally, the abundances of obesogenic microbiota, such as Ruminiclostridium and Oscillibacter were also decreased after MGE treatment. In summary, our findings demonstrate that MGE can modulate gut microbiota in obese mice and shed new light on how it alleviates obesity.

The effects of Ascophyllum nodosum, Camellia sinensis-leaf extract, and their joint interventions on glycolipid and energy metabolism in obese mice

“…Notably, the analysis of differential bacterial abundances in this research was based on the Kruskal–Wallis rank-sum test, which may increase the probability of obtaining false positives or false negatives in this kind of dataset. Elevated F:B values are known to drive obesity by promoting lipid uptake by the intestine and accelerating energy absorption ( 43 ). In the present study, we discovered that the intervention of plant extracts significantly reduced F:B values compared to the HFD group.…”

Mogroside-rich extract from Siraitia grosvenorii fruits protects against heat stress-induced intestinal damage by ameliorating oxidative stress and inflammation in mice

“…33 Mogroside-rich extract (MGE) is a kind of mogroside extract. In our previous study, MGE ameliorate obesity by modulating gut microbiota 34 and improved age-related oestrous cycle disorder and the decline in ovarian reserve function by reducing ovarian inflammatory stress in mice. 35 Therefore, mogroside extract has the potential to be used as a therapeutic agent for adverse reactions induced by heat stress.…”

Effects of Siraitia grosvenorii seed flour on the properties and quality of steamed bread

“…Siraitia grosvenorii , also known as longevity fruit, is a species of the cucurbitaceae and is mainly planted in Guangxi, Hunan, and Guangdong provinces of China. As a medicinal and food homolog ( 1 ), S. grosvenorii has been used in traditional Chinese medicine and beverages for hundreds of years in China, due to its biological functions, including lowering lipid level ( 2 ), lowering blood glucose level ( 3 ), improving immune functions ( 4 ), and anti-inflammations ( 5 ). The triterpenoid in this fruit have been used as low-calorie sweeteners in recent years.…”