Mogroside V reduce OVA-induced pulmonary inflammation based on lung and serum metabolomics

Mogroside-rich extract from Siraitia grosvenorii fruits protects against heat stress-induced intestinal damage by ameliorating oxidative stress and inflammation in mice

“…30 Liu et al reported that mogroside V effectively reduced the levels of IgE, TNF-α, and IL-5 to ameliorated ovalbumin-induced lung inflammation in mice. 31 Moreover, the antioxidant effect of the mogroside extract was also observed in some experiments. For example, the novel polysaccharide from Siraitia grosvenorii residues showed certain antioxidant activity in vitro , especially its DPPH free radical scavenging effect.…”

Protective effects of Descurainia sophia seeds extract and its fractions on pulmonary edema by untargeted urine and serum metabolomics strategy

“…It has been reported that vitamin B6 deficiency can reduce its antioxidant capacity or promote inflammatory reactions directly ( Lee et al, 2018 ). Further study observed that the pyridoxal level was inversely associated with the degree of inflammatory response and oxidative stress, and that a low pyridoxine level could enhance inflammation ( Liu et al, 2021 ). Compatible with those observations, the content of pyridoxal and pyridoxine in the urine of the model group decreased, which could further aggravate inflammatory damage to the lung.…”

“…Tryptophan is metabolized mainly by a rate-limiting enzyme, indoleamine 2,3-dioxygenase (IDO) through the kynurenine pathway (KP) ( Badawy, 2017 ). IDO can be driven by the gut microbiota and proinflammatory cytokines (e.g., interferon-γ, TNF-α, prostaglandin-E2 ( Li et al, 2020 ; Liu et al, 2021 ; Zhou, N. et al, 2018 ). In the present study, levels of tryptophan catabolites through the KP (e.g., kynurenic acid, xanthurenic acid) were increased in the model group, suggesting upregulated IDO activity, microbial dysbiosis and release of proinflammatory factors in PE.…”

“…It has been reported that vitamin B6 deficiency can reduce its antioxidant capacity or promote inflammatory reactions directly (Lee et al, 2018). Further study observed that the pyridoxal level was inversely associated with the degree of inflammatory response and oxidative stress, and that a low pyridoxine level could enhance inflammation (Liu et al, 2021).…”

Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis

“…12 Our previous studies demon-strated that MV could alleviate OVA-induced pulmonary inflammation in mice. 13 In addition, MV can reduce the production of proinflammatory cytokines, protecting lung tissue against acute lung injury induced by LPS. 14 In RAW 264.7 cells, MV reduces the increase in reactive oxygen species (ROS) levels induced by LPS.…”