Mohs micrographic surgery for extramammary Paget disease: A pooled analysis of individual patient data

Extramammary Paget Disease of the Vulva: A Case Series Examining Treatment, Recurrence, and Malignant Transformation

“…A 2013 meta-analysis presented 90 cases (of which only 21 had EMPD of the vulva) with median follow-up of 27.5 months with a low recurrence rate of 12.2%. 19 Mohs microsurgery may provide complete margin control through histologic assessment of the entire periphery. If a large area is affected by EMPD, however, MMS excisions may require advanced closure techniques with a similar impact on form and function.…”

5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease

“…However, frozen sections have a false-negative rate of 10.4%, up to as high as 40%, and is known to have no improvement in disease outcome (15,16). MMS may lower local recurrence rate (17)(18)(19)(20) but is timeconsuming and requires additional faculty for use.…”

Cancers of the Vulva and Vagina

“…257 Rarely, Paget's disease may become invasive, and metastases to groin nodes have been reported. Negative surgical margins have only limited correlation with freedom from local relapse.…”