Moisture plasticization for enteric Eudragit® L30D-55-coated pellets prior to compression into tablets

Rujivipat, Soravoot; Bodmeier, Roland

doi:10.1016/j.ejpb.2012.01.003

Cited by 27 publications

(9 citation statements)

References 21 publications

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“…Functional polymers play an important role when it comes to controlled drug release formulations. Poly(meth)acrylates, which are known as EUDRAGIT ® polymers, are commonly employed and offer several advantages in various formulations [38][39][40]. Eudragit enteric coating polymers contain free carboxylic acid groups [41].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity

et al. 2020

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This study aimed at improving the targeting and cytotoxic effect of ellagic acid (EA) on colon cancer cells. EA was encapsulated in chitosan (CHIT) polymers then coated by eudragit S100 (ES100) microparticles. The release of EA double-coated microparticles (MPs) was tested at simulative pH values. Maximum release was observed at 24 h and pH 7.4. The cytotoxicity of EA MPs on HCT 116 colon cancer cells was synergistically improved as compared with raw EA. Cell-cycle analysis by flow cytometry suggested enhanced G2-M phase colon cancer cell accumulation. In addition, a significantly higher cell fraction was observed in the pre-G phase, which highlighted the enhancement of the proapoptotic activity of EA formulated in the double-coat mixture. Annexin-V staining was used for substantiation of the observed cell-death-inducing activity. Cell fractions were significantly increased in early, late, and total cell death. This was backed by high elevation in cellular content of caspase 3. Effectiveness of the double-coated EA to target colonic tissues was confirmed using real-time iohexol dye X-ray radiography. In conclusion, CHIT loaded with EA and coated with ES100 formula exhibits improved colon targeting as well as enhanced cytotoxic and proapoptotic activity against HCT 116 colon cancer when compared with the administration of raw EA.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity

et al. 2020

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“…The drug degradation rate could be affected by excipient hygroscopicity after storage in high humidity due to its sensitivity to water [26]. Besides, the film with Eudragit® L 30D-55 as a coating polymer exhibits certain moisture permeability and allows for wateruptake, which could potentially cause drug degradation under high moisture [8].…”

Section: Drug Degradation Rate Studiesmentioning

confidence: 99%

“…[1,4]. However, the compression of pellets into tablets creates several challenges: (1) to achieve non-segregated mixture of pellets and fillers/binders to ensure uniform distribution of pellets in tablets and multi-particulate function of the system [5,6]; (2) to form flexible polymeric film with elongation value greater than 75%, so it can withstand the compaction pressure without damage and neutralize the pellet deformation to ensure the designed release profiles of the pellets [7,8]. These challenges have constrained the development of traditional pellet-containing tablets (PCT).…”

Section: Introductionmentioning

confidence: 99%

Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients

et al. 2015

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“…In addition, moisture is also essential for the successful compression of coated pellets. Rujivipat and Bodmeier (2012) investigated how important moisture play role in the coating films properties. Coated pellets were stored at different humidity at room temperature for 1 month, including 52%, 75%, 84%, 95% and 100% RH.…”

Section: Formulation Factormentioning

confidence: 99%

Investigation for the quality factors on the tablets containing medicated pellets

Tan

2016

Saudi Pharmaceutical Journal

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Sustained and controlled pellets are considered as one of the ideal dosage forms. Due to the large coverage area of pellets, loaded drugs can be absorbed completely in the body and bioavailability is improved correspondingly. Coated pellets-containing tablet is a special oral formulation consisting of various pellets with different release rate. Desired rate of drug release rate can be achieved by adjusting the proportion of pellets. However, this formulation faces strict requirements in the process of preparation. Several factors will influence release behavior of tablets, including pellet cores, coating, and tabletting. Therefore, these factors will be investigated sufficiently in this review to provide valuable information for manufacturing process.

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Moisture plasticization for enteric Eudragit® L30D-55-coated pellets prior to compression into tablets

Cited by 27 publications

References 21 publications

RETRACTED: Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity

RETRACTED: Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity

Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients

Investigation for the quality factors on the tablets containing medicated pellets

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