Moisturizing effects of topical nicotinamide on atopic dry skin

Soma, Yoshinao; Kashima, Masato; Imaizumi, Akiko; Takahama, Hideto; Kawakami, Tamihiro; Mizoguchi, Masahiro

doi:10.1111/j.1365-4632.2004.02375.x

Cited by 74 publications

(55 citation statements)

References 25 publications

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“…Niacinamide is involved in the biosynthesis of ceramides in keratinocytes by activating the mRNA expression of serine palmitoyltransferase, the key enzyme for the sphingolipid synthesis [30]. As a result the increased rate of ceramide synthesis again influences the barrier effect of the stratum corneum [31,32]. Niacinamide is also a potent inhibitor of cAMP-phosphodiesterase, stabilises the mast cells and therefore reduces the release of histamine [33,34,35,36,37,38,39].…”

Section: Biological Effects With Dermatological Relevancementioning

confidence: 99%

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Wohlrab¹,

Kreft²

2014

Skin Pharmacol Physiol

107

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Niacinamide, an amide of vitamin B₃ (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given a sufficient bioavailability, niacinamide has antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic and lightening effects depending on its concentration. Within a complex metabolic system niacinamide controls the NFκB-mediated transcription of signalling molecules by inhibiting the nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically founded evaluation, it can be stated that the use of niacinamide in galenic preparations for epicutaneous application offers most interesting prospects.

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Section: Biological Effects With Dermatological Relevancementioning

confidence: 99%

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Wohlrab¹,

Kreft²

2014

Skin Pharmacol Physiol

107

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“…The existing preclinical data show that NIC has the potential for topical application in cosmetic or pharmaceutical industry because of its barrier restoration, anti-inflammatory, and depigmenting effects. 41,42 Moreover, NIC has a therapeutic potential as an inhibitor of proinflammatory cytokines in inflammatory disease. 43 Activation of NF-κB is a very important factor in both lesional and nonlesional skin from patients with psoriasis.…”

mentioning

confidence: 99%

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

Wan

Pan

Long

et al. 2017

IJN

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The hybrid system based on nanoparticles (NPs) self-assembled by the conjugations of hyaluronic acid with cholesterol (HA–Chol NPs) combined with nicotinamide (NIC) for tacrolimus (FK506), ie, FK506 NPs–NIC, has been confirmed to exhibit a significant synergistic effect on FK506 permeation through and into intact skin; thus, it may be a promising approach for FK506 to effectively treat skin diseases. The aim of this study was to evaluate its potential for the treatment of psoriasis. In vitro permeation through the psoriatic skin was carried out, and the results revealed that the combination of NPs with NIC exhibited a significant synergistic effect on FK506 deposition within the psoriatic skin (3.40±0.67 μg/cm 2 ) and penetration through the psoriatic skin (30.86±9.66 μg/cm 2 ). The antipsoriatic activity of FK506 NPs–NIC was evaluated through the treatment for imiquimod (IMQ)-induced psoriasis. The psoriasis area and severity index (PASI) score demonstrated that FK506 HA–Chol NPs–NIC exerted the effect on ameliorating the skin lesions comparable to clobetasol propionate (a positive drug for psoriasis) and superior to commercial FK506 ointment (Protopic ® ), and the histological study showed that it presented a synergistic effect on antipsoriasis after FK506 incorporation into NPs combined with NIC hydrotropic system, which might ultimately increase the therapeutic effect and minimize the systemic side effects by reducing the overall dose of FK506. RAW 264.7 cell uptake presented the enhancement of drugs delivered into cells by HA–Chol NPs–NIC. The antiproliferative activity on HaCaT cells identified that FK506 HA–Chol NPs–NIC exhibited significant inhibiting effects on HaCaT proliferation. The results support that the combination of HA–Chol NPs with NIC is a promising approach for FK506 for the treatment of psoriasis.

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“…Moreover, C. olitorius contains significant amounts of vitamin E and vitamin B 3 [2]. It has previously been reported that vitamin E improved the symptoms of AD by decreasing the concentrations of inflammatory factors [22], and that nicotinamide, which is the amide of vitamin B 3 , promoted a decrease in TEWL on atopic dry skin [23]. These compounds may play a role in the observed efficacy of COEW on ADlike inflammation.…”

Section: Skin Hydrating Effects Of Corchorus Olitorius Extract In a Mmentioning

confidence: 97%

Skin Hydrating Effects of <i>Corchorus olitorius</i> Extract in a Mouse Model of Atopic Dermatitis

Yokoyama¹,

Hiramoto²,

Fujikawa³

et al. 2014

JCDSA

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Background: Corchorus olitorius leaf contains a significant amount of mucilaginous polysaccharide. It has been generally accepted that the polysaccharides derived from botanical extracts increase skin hydration. Since skin hydration improves skin barrier function, it is one of the most effective treatments for atopic dermatitis (AD). However, other components of botanical extracts other than polysaccharides may influence skin hydration and transepidermal water loss (TEWL). The aim of this study was to evaluate the hydration efficacy and skin barrier protection afforded to the skin after exposure to Corchorus olitorius extract without high-molecular-weight compounds (COEW), such as polysaccharides. Methods: NC/Nga mice possess disrupted skin barrier function, and were used as a model for AD. A stable base cream was supplemented with 0.2% COEW and applied to the dorsal skin of these mice. Skin hydration and TEWL were analyzed after a 14-d period of daily application. AD scores and plasma immunoglobulin E (IgE) concentrations were also investigated. Results: Compared to control mice, mice treated with the COEW cream showed significantly increased skin hydration and reduced TEWL. Plasma IgE concentrations were not affected by the COEW cream, whereas an increase in AD score in NC/Nga mice was prevented because of the application of the COEW cream. Conclusions: COEW has the ability to maintain hydration of the skin, and to prevent the disruption of skin barrier function, which leads to the aggravation of AD. COEW may be used as an adjunct treatment for AD.

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Moisturizing effects of topical nicotinamide on atopic dry skin

Abstract: Nicotinamide cream is a more effective moisturizer than white petrolatum on atopic dry skin, and may be used as a treatment adjunct in atopic dermatitis.

Cited by 74 publications

References 25 publications

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

Skin Hydrating Effects of <i>Corchorus olitorius</i> Extract in a Mouse Model of Atopic Dermatitis

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Moisturizing effects of topical nicotinamide on atopic dry skin

Abstract: Nicotinamide cream is a more effective moisturizer than white petrolatum on atopic dry skin, and may be used as a treatment adjunct in atopic dermatitis.

Cited by 74 publications

References 25 publications

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Niacinamide - Mechanisms of Action and Its Topical Use in Dermatology

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

Skin Hydrating Effects of &lt;i&gt;Corchorus olitorius&lt;/i&gt; Extract in a Mouse Model of Atopic Dermatitis

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Skin Hydrating Effects of <i>Corchorus olitorius</i> Extract in a Mouse Model of Atopic Dermatitis