Moisturizing treatment of patients with atopic dermatitis and ichthyosis vulgaris improves dry skin, but has a modest effect on gene expression regardless of <scp>FLG</scp> genotype

Hoppe, Torborg; Winge, M; Bradley, J. F. N.; Nordenskjöld, Magnus; Vahlquist, Anders; Törmä, Hans; Berne, Berit

doi:10.1111/jdv.12333

Cited by 20 publications

(18 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…can dramatically impair quality of life of many patients. On the other hand, appropriate moisturization and emollient treatment of the skin can alleviate symptoms, and in some cases, they are even able to prevent the onset of AD (Hoppe et al, 2015;Sawatzky et al, 2016;Sugiura et al, 2014). Although inappropriate epidermal ceramide production is thought to be the most important player in these processes, a growing body of evidence now supports the concept that dysregulation of SG functions and the subsequent alterations in the SLP are also fundamental.…”

Section: Discussionmentioning

confidence: 99%

Endocannabinoid Tone Regulates Human Sebocyte Biology

Zákány

Oláh

Markovics

et al. 2018

Journal of Investigative Dermatology

View full text Add to dashboard Cite

We have previously shown that endocannabinoids (eCBs) (e.g., anandamide) are involved in the maintenance of homeostatic sebaceous lipid production in human sebaceous glands and that eCB treatment dramatically increases sebaceous lipid production. Here, we aimed to investigate the expression of the major eCB synthesizing and degrading enzymes and to study the effects of eCB uptake inhibitors on human SZ95 sebocytes, thus exploring the role of the putative eCB membrane transporter, which has been hypothesized to facilitate the cellular uptake and subsequent degradation of eCBs. We found that the major eCB synthesizing (N-acyl phosphatidylethanolamine-specific phospholipase D, and diacylglycerol lipase-α and -β) and degrading (fatty acid amide hydrolase, monoacylglycerol lipase) enzymes are expressed in SZ95 sebocytes and also in sebaceous glands (except for diacylglycerol lipase-α, the staining of which was dubious in histological preparations). eCB uptake-inhibition with VDM11 induced a moderate increase in sebaceous lipid production and also elevated the levels of various eCBs and related acylethanolamides. Finally, we found that VDM11 was able to interfere with the proinflammatory action of the TLR4 activator lipopolysaccharide. Collectively, our data suggest that inhibition of eCB uptake exerts anti-inflammatory actions and elevates both sebaceous lipid production and eCB levels; thus, these inhibitors might be beneficial in cutaneous inflammatory conditions accompanied by dry skin.

show abstract

Section: Discussionmentioning

confidence: 99%

Endocannabinoid Tone Regulates Human Sebocyte Biology

Zákány

Oláh

Markovics

et al. 2018

Journal of Investigative Dermatology

View full text Add to dashboard Cite

show abstract

“…The preliminary in vitro data suggest that xylitol leads to an elevated protein expression of filaggrin (7). Since the application of glycerol alone does not seem to influence the expression of filaggrin in vivo (22), it can be assumed that xylitol is responsible for the increased quantity of filaggrin. However, the exact mechanism via which this polyol elevates the expression of filaggrin demands further investigation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin

Korponyai¹,

Szél²,

Behány³

et al. 2017

Acta Derm Venerol

View full text Add to dashboard Cite

Glycerol and xylitol hydrate the skin and improve its barrier function over a short period. We studied the effects of glycerol and xylitol on the physiological properties and morphology of the skin after longer-term application. Twelve volunteers with dry skin were examined. Three areas on the arms were determined. Area 1 served as untreated control. The vehicle was applied to area 2, while area 3 was treated twice daily with a formulation containing glycerol (5%) and xylitol (5%) for 14 days. Transepidermal water loss (TEWL), hydration and biomechanical properties of the skin were monitored. Biopsies were taken for routine histology and immunohistochemistry for filaggrin and matrix metalloproteinase-1 (MMP-1). The polyols increased the skin hydration and protein quantity of filaggrin, elevated the interdigitation index, decreased the TEWL and improved the biomechanical properties of the skin, but did not change the protein expression of MMP-1. A combination of glycerol and xylitol can be useful additional therapy for dry skin.

show abstract

“…At a concentration of 10%, urea was shown to improve skin hydration and to decrease TEWL in AD patients (Sasaki, Tadaki, & Tagami, ). However, two recent studies claim that urea enhances skin hydration in AD without reducing TEWL (Hoppe et al, ; Ahmad Nasrollahi et al, ). These contradictory results might be explained by the low concentration of urea used in the formulation used (only 5%).…”

Section: Urea and The Treatment Of Dermatological Conditionsmentioning

confidence: 99%

“…At a concentration of 10%, urea was shown to improve skin hydration and to decrease TEWL in AD patients (Sasaki, Tadaki, & Tagami, 1989). However, two recent studies claim that urea enhances skin hydration in AD without reducing TEWL (Hoppe et al, 2015;Ahmad Nasrollahi et al, 2018).…”

Section: Urea and The Functional Integrity Of The Stratum Corneummentioning

confidence: 99%

Topical urea in skincare: A review

Celleno

2018

Dermatologic Therapy

118

View full text Add to dashboard Cite

Alterations in barrier function are associated with a number of skin diseases, including xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor of the skin, plays an important role in the preservation of skin hydration and integrity. Several studies have investigated the effects of urea in the clinical setting. Here, we summarize the available clinical evidence regarding the effects of urea in the maintenance of healthy skin and management of skin disorders. At lower doses (≤10%), urea‐containing topical formulations act as a skin moisturizer, while at higher concentrations (>10% urea), urea‐based preparations exert a keratolytic action. Urea is also useful in combination therapies with anti‐inflammatory and anti‐fungal drugs, due to its activity as a penetration enhancer.

show abstract

Moisturizing treatment of patients with atopic dermatitis and ichthyosis vulgaris improves dry skin, but has a modest effect on gene expression regardless of FLG genotype

Abstract: Moisturizing treatment improves dry skin and certain aspects of abnormal skin barrier function, especially in patients with AD/IV and dual FLG mutations, but does not normalize the epidermal gene expression profile.

Cited by 20 publications

References 11 publications

Endocannabinoid Tone Regulates Human Sebocyte Biology

Endocannabinoid Tone Regulates Human Sebocyte Biology

Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin

Topical urea in skincare: A review

Contact Info

Product

Resources

About