There are many ways for osteosynthetical treatment of broken bones via fixation. One of them is internal fixation by headless screw, which causes desired compression of bone fragments. In cooperation with medics and industry, FEM simulation (i.e. stress, deformation) was done for prototype of headless screw for 5th metatarsus. Simulations were based on experiment and are followed by other simulation methods too. The aim of this research is to describe basis of issue, define mechanical dependences in headless screws and assessment of headless screws. According to the results, the headless screws can be applied in orthopaedics treatment of fractures.