Molecular action mechanisms of solar infrared radiation and heat on human skin

Akhalaya, M. Ya.; Максимов, Г. В.; Rubin, A. B.; Lademann, J.; Darvin, Maxim E.

doi:10.1016/j.arr.2014.03.006

Cited by 121 publications

(151 citation statements)

References 99 publications

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“…Approximately 50% of the NIR irradiation that reaches the skin is absorbed in the dermis [2] promoting premature skin aging [44][45][46]. It has been found that oxidative stress is induced not only in the UV, but also in the NIR spectral range [47]. This effect was observed by a depletion of dermal carotenoids after NIR irradiation [48].…”

Section: Effect Of Radical Formation In the Visible And Near Infraredmentioning

confidence: 93%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

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Organisms produce free radicals which are essential for various metabolic processes (enzymatic oxidation, cellular respiration, signaling). Antioxidants are important chemical compounds that specifically prevent the oxidation of substances by scavenging radicals, especially reactive oxygen species (ROS). Made up of one or two unpaired electrons, ROS are free radicals that are highly reactive and can attack other metabolites. By using electron paramagnetic resonance (EPR) spectroscopy, it is possible to measure paramagnetic substances such as free radicals. Therefore the dermal antioxidant activity can be determined by applying semi-stable radicals onto the skin and measuring the antioxidant-induced radical scavenging activity in the skin. In recent years, EPR has been OPEN ACCESS Cosmetics 2015, 2 287 developed as a spectroscopic method for determining the antioxidant status in vivo. Several studies have shown that an additional uptake of dietary supplements, such as carotenoids or vitamin C in physiological concentrations, provide a protective effect against free radicals. Using the EPR technique it could be demonstrated that the radical production in stress situations, such as irradiation with infrared and visible light, was reduced with time. However, not only the oral uptake of antioxidants, but also the topical application of antioxidants, e.g., a hyperforin-rich cream, is very useful against the development of oxidative stress. Regular application of a hyperforin-rich cream reduced radical formation. The skin lipids, which are very important for the barrier function of the skin, were also stabilized.

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Section: Effect Of Radical Formation In the Visible And Near Infraredmentioning

confidence: 93%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

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“…The negative effects on human skin are usually associated with UVB and UVA radiation [19]. UVB radiation is characterized as a mutagenic and cancer-inducing agent because it causes direct damage to the DNA.…”

Section: Introductionmentioning

confidence: 99%

Elastin structure and its involvement in skin photoageing

Weihermann

Lorencini

Brohem

et al. 2016

Intern J of Cosmetic Sci

148

102

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Skin aging is a complex process that may be caused by factors that are intrinsic and extrinsic to the body. Ultraviolet (UV) radiation represents one of the main sources of skin damage over the years and characterizes a process known as photoaging. Among the changes that affect cutaneous tissue with age, the loss of elastic properties caused by changes in elastin production, increased degradation and/or processing produces a substantial impact on tissue esthetics and health. The occurrence of solar elastosis is one of the main markers of cutaneous photoaging and is characterized by disorganized and non-functional deposition of elastic fibers. The occurrence of UV radiation-induced alternative splicing of the elastin gene, which leads to inadequate synthesis of the proteins required for the correct assembly of elastic fibers, is a potential explanation for this phenomenon. Innovative studies have been fundamental for the elucidation of rarely explored photoaging mechanisms and have enabled the identification of effective therapeutic alternatives such as cosmetic products. This review addresses cutaneous photoaging and the changes that affect elastin in this process.R esum e Le vieillissement de la peau est un processus complexe qui peutêtre caus e par des facteurs intrins eques et extrins eques du corps. Les rayons ultraviolets (UV) repr esentent l'une des principales sources de dommages de la peau au fil des ans et caract erise un processus connu sous le nom de photo-vieillissement. Parmi les changements qui affectent le tissu cutan e avec l'âge, la perte des propri et es elastiques caus ees par des changements dans la production d' elastine, augmentation de la d egradation et / ou le traitement, produit un impact important sur l'esth etique et la sant e des tissus. La survenue d'une elastose solaire est l'un des principaux marqueurs de photo-vieillissement cutan e et se caract erise par un d epôt d esordonn e et non-fonctionnel des fibres elastiques. L'apparition d'un epissage alternatif du g ene de l' elastine induit par le rayonnement UV, ce qui conduit a une synth ese insuffisante des prot eines n ecessaires a l'assemblage correct des fibres elastiques, est une explication possible de ce ph enom ene. Des etudes novatrices ont et e fondamentales pour l' elucidation des m ecanismes de photovieillissement rarement explor es et ont permis l'identification d'alternatives th erapeutiques efficaces, tels que les produits cosm etiques. Cette revue porte sur le photo-vieillissement cutan e et les changements qui affectent l' elastine dans ce processus.

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“…1). This is a low-power light source (fiber-coupled optical power of 10 mW) corresponding to approximately 1 J/cm 2 which is considered a low dose [13]. As one measurement usually took approximately 1 second at a time, we believe, it didn't significantly increase the temperature of skin surface or cause any other change in skin physiology.…”

Section: Methodsmentioning

confidence: 99%

Comparison of a near-infrared reflectance spectroscopy system and skin conductance measurements for in vivo estimation of skin hydration: a clinical study

Saknīte

Zavorins

Zablocka

et al. 2017

JBPE

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Abstract. Diffuse reflectance spectroscopy system was developed for estimation of skin hydration in the near-infrared spectral range of 900-1700 nm. Experimental setup consisted of a near-infrared spectrometer, Y-type fiber optics probe with 1 detection and 6 illumination fibers, halogen-tungsten light source and a PC. By analyzing diffuse reflectance spectrum, a parameter representing skin hydration by performing baseline correction and calculating the area under the 1450 nm water absorption maximum is proposed. A clinical study was performed acquiring data of skin hydration of 39 patients' forearm skin. Results of the developed system are compared to results obtained by a commercial device based on skin conductance measurements. © 2017 Journal of Biomedical Photonics & Engineering.Keywords: Diffuse reflectance; near-infrared; spectroscopy; water; absorption; hydration; skin.

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Molecular action mechanisms of solar infrared radiation and heat on human skin

Cited by 121 publications

References 99 publications

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Elastin structure and its involvement in skin photoageing

Comparison of a near-infrared reflectance spectroscopy system and skin conductance measurements for in vivo estimation of skin hydration: a clinical study

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