Elastin structure and its involvement in skin photoageing

Abstract

Skin aging is a complex process that may be caused by factors that are intrinsic and extrinsic to the body. Ultraviolet (UV) radiation represents one of the main sources of skin damage over the years and characterizes a process known as photoaging. Among the changes that affect cutaneous tissue with age, the loss of elastic properties caused by changes in elastin production, increased degradation and/or processing produces a substantial impact on tissue esthetics and health. The occurrence of solar elastosis is one of the main markers of cutaneous photoaging and is characterized by disorganized and non-functional deposition of elastic fibers. The occurrence of UV radiation-induced alternative splicing of the elastin gene, which leads to inadequate synthesis of the proteins required for the correct assembly of elastic fibers, is a potential explanation for this phenomenon. Innovative studies have been fundamental for the elucidation of rarely explored photoaging mechanisms and have enabled the identification of effective therapeutic alternatives such as cosmetic products. This review addresses cutaneous photoaging and the changes that affect elastin in this process.R esum e Le vieillissement de la peau est un processus complexe qui peutêtre caus e par des facteurs intrins eques et extrins eques du corps. Les rayons ultraviolets (UV) repr esentent l'une des principales sources de dommages de la peau au fil des ans et caract erise un processus connu sous le nom de photo-vieillissement. Parmi les changements qui affectent le tissu cutan e avec l'âge, la perte des propri et es elastiques caus ees par des changements dans la production d' elastine, augmentation de la d egradation et / ou le traitement, produit un impact important sur l'esth etique et la sant e des tissus. La survenue d'une elastose solaire est l'un des principaux marqueurs de photo-vieillissement cutan e et se caract erise par un d epôt d esordonn e et non-fonctionnel des fibres elastiques. L'apparition d'un epissage alternatif du g ene de l' elastine induit par le rayonnement UV, ce qui conduit a une synth ese insuffisante des prot eines n ecessaires a l'assemblage correct des fibres elastiques, est une explication possible de ce ph enom ene. Des etudes novatrices ont et e fondamentales pour l' elucidation des m ecanismes de photovieillissement rarement explor es et ont permis l'identification d'alternatives th erapeutiques efficaces, tels que les produits cosm etiques. Cette revue porte sur le photo-vieillissement cutan e et les changements qui affectent l' elastine dans ce processus.

Fernblock Prevents Dermal Cell Damage Induced by Visible and Infrared A Radiation

“…Among the changes that affect cutaneous tissue with age, the loss of elastic properties caused by increased elastin degradation and/or processing and changes in elastin production cause a substantial impact on tissue esthetics and health. The occurrence of solar elastosis is one of the main markers of cutaneous photoaging and is characterized by disorganized and non-functional deposition of elastic fibers [33]. In summary, as with fibrillins, our results indicate that FB per se promoted the expression of ELN in fibroblasts.…”

Transcriptome analysis of ultraviolet A‐induced photoaging cells with deep sequencing

“…Elastosis, denaturation of elastin fibers, occurs with the exposure of skin to UV radiation . Previous studies have found that the occurrence of UV radiation‐induced alternative splicing of the elastin gene is a potential explanation for this phenomenon . The results of our study about elastin gene expression also provided the detail information for elastin reducing in the photoaged skin.…”

“…24 Previous studies have found that the occurrence of UV radiationinduced alternative splicing of the elastin gene is a potential explanation for this phenomenon. 25 The results of our study about elastin gene expression also provided the detail information for elastin reducing in the photoaged skin. We presume that the decrease of elastin in photoaged skin is the result of a combination of downregulation of elastin gene expression and denaturation of proper elastin fibers.…”

Role of the extracellular matrix in skin aging and dedicated treatment - State of the art

“…When the mechanical force is removed, elastin folds back on itself and its fibers become shortened. It goes without saying that the optimal functionality of elastin would also be dependent on adequate tissue hydration [19] .…”