Role of the extracellular matrix in skin aging and dedicated treatment - State of the art

Sparavigna, Adele

doi:10.20517/2347-9264.2019.73

Cited by 26 publications

(31 citation statements)

References 23 publications

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“…ECM degrades with age losing HA, 8 the main extracellular matrix component in the skin. HA can exist both as freely available but also bound to cells or proteins containing a hyaluronic acid-binding domain 29 such as CD44.…”

Section: Discussionmentioning

confidence: 99%

“…Research is currently focusing on ECM composition and signaling. 8 Recently, results in this field have contributed to developing effective strategies for the prevention and treatment of degenerative diseases and signs of cutaneous aging. 9 The product under study contains 2% hyaluronic acid (HA) (200-400 kDa), the primary component of the ECM of human connective tissues, and the most used filler and rejuvenating agent in anti-age treatments and injectables.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vitro and in vivo Evaluation on the Safety and Efficacy of a Brand-New Intracutaneous Filler with α1-R-Collagen

Rinaldi

Pinto

Trink³

et al. 2021

CCID

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Nowadays, the most advanced skin anti-aging treatments are addressed to restore the extracellular matrix (ECM) homeostasis. ECM is considered the main player not only as physical support of the tegument but also at the biochemical level, thanks to its capacity to exchange nutrients, water, cellular mediators, and growth factors within and between cells. This study aimed to evaluate the in vitro and in vivo efficacy and aesthetic performance of a brand-new intracutaneous filler. The latter is based on novel concepts: besides filling it exerts a homeostatic balance of nutrients able to delay the skin aging process by sustaining physiological rejuvenation of the tissue and in the surrounding injection/implantation area. The brand-new intracutaneous filler was tested for in vitro capacity to stimulate extracellular matrix components production. Therefore, a single session for injection of the product under study was performed by a specialized dermatologist, using the bolus technique on the zygomatic protuberance of 20 healthy female subjects with midface volume loss, caused by aging. Results confirmed the important and long-term volumizing, anti-wrinkle, the hydrating activity of this product after one single injection session. The biological outcomes also support product effectiveness in skin structure restoration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vitro and in vivo Evaluation on the Safety and Efficacy of a Brand-New Intracutaneous Filler with α1-R-Collagen

Rinaldi

Pinto

Trink³

et al. 2021

CCID

Self Cite

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“…Skin aging, determined by intrinsic (chronological) and extrinsic (exposure to ultra-violet light or photo-aging), along with the importance of estrogen in maintaining dermal health has been reviewed in detail elsewhere [51][52][53][54][55][56][57][58][59]. Research on the skin microbiome is an emerging area of study [6][7][8]19, 30], and more is known about the microbiome of the gut than the skin.…”

Section: Skin Aging and The Skin Microbiome (Intrinsic And Extrinsic ...mentioning

confidence: 99%

Estrogen Action and Gut Microbiome Metabolism in Dermal Health

Lephart

Naftolin²

2022

Dermatol Ther (Heidelb)

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Emerging scientific advances in microbial research linking estrogens and the gut-skin microbiome in reference to dermal health are featured in this narrative review of journal reports and reviews from January 2018 through February 2022. Background information on advances in microbial research along with defining the microbiota and microbiome is presented in brief. The development of and factors that influence the gut microbiome in health and disease as well as the intrinsic and extrinsic factors influencing the skin microbiome and skin aging are summarized. New information on the development and changes of organ microbiomes have exposed similarities between skin and gut structure/function, microbial components/diversity/taxonomy and how they impact the immune response for combating disease and enhancing wellness. Estrogens promote health and support homeostasis in general and directly impact dermal health. Moreover, the gut, based upon the level of the microbial enzyme b-glucuronidase, which regulates estrogen's enterohepatic recirculation, constitutes a gut-skin microbial axis. This axis revolves around the systemically available estrogen to support immune function, counteract inflammation and oxidative stress, and decrease the risk of hormone-dependent skin cancers. These data support the direct effect of estrogens on skin health and the interaction of diet on dermal health via effects on the gut microflora. Finally, the potential for bioactive botanicals containing phytoestrogens or selective estrogen receptor modulators (SERMs) to evade the effects of gut b-glucuronidase expressing flora is proposed that may have a positive impact on skin.

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“…Vascular calcification accompanies aging and atherosclerosis, but hitherto, it has not been a direct therapeutic target [ 178 ]. In this context, ECM-focused therapies may be explored to expand ongoing efforts limited to skin aging [ 179 ].…”

Section: Perspectivesmentioning

confidence: 99%

Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix

Ribeiro-Silva

Nolasco

Krieger

et al. 2021

IJMS

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Vascular aging is accompanied by the fragmentation of elastic fibers and collagen deposition, leading to reduced distensibility and increased vascular stiffness. A rigid artery facilitates elastin to degradation by MMPs, exposing vascular cells to greater mechanical stress and triggering signaling mechanisms that only exacerbate aging, creating a self-sustaining inflammatory environment that also promotes vascular calcification. In this review, we highlight the role of crosstalk between smooth muscle cells and the vascular extracellular matrix (ECM) and how aging promotes smooth muscle cell phenotypes that ultimately lead to mechanical impairment of aging arteries. Understanding the underlying mechanisms and the role of associated changes in ECM during aging may contribute to new approaches to prevent or delay arterial aging and the onset of cardiovascular diseases.

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Role of the extracellular matrix in skin aging and dedicated treatment - State of the art

Cited by 26 publications

References 23 publications

In vitro and in vivo Evaluation on the Safety and Efficacy of a Brand-New Intracutaneous Filler with α1-R-Collagen

In vitro and in vivo Evaluation on the Safety and Efficacy of a Brand-New Intracutaneous Filler with α1-R-Collagen

Estrogen Action and Gut Microbiome Metabolism in Dermal Health

Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix

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