Molecular analysis and prevalence of Huntington disease in northwestern Iran

Khaniani, Mahmoud Shekari; Aob, Parisa; Ranjouri, Mohammadreza; Derakhshan, Sima Mansoori

doi:10.3906/sag-1510-25

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…The limitations of the present study are that the occupational status of each subject was not determined and we did not correlate smoking status with polymorphism. All triplet repeat disorders show anticipation and a significant correlation between age at the onset of the disease and the length of the expanded repeat [ 48 , 49 ]. The current data is insufficient to conclude whether IVF patients who display AR CAG expansion may transfer infertility to their descendants.…”

Section: Discussionmentioning

confidence: 99%

Association of trinucleotide repeat polymorphisms CAG and GGC in exon 1 of the androgen receptor gene with male infertility: a cross-sectional study

ASHRAF¹,

KAZMI²,

TARIQ³

et al. 2022

Turkish Journal of Medical Sciences

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Background/aim Infertility is a global problem that brings about serious sexual and social consequences that strain the health sector and society. The expansion of CAG and GGC repeats in androgen receptor ( AR ) gene (Ensembl number ENSG00000169083) may lead to reduced fertility. Our objective was to determine the association of CAG and GGC repeats with altered sperm parameters in male infertile subjects. Materials and methods This was a cross-sectional study conducted at Aga Khan University, Karachi, Pakistan. A total of 376 males were recruited, out of which group A (N = 208) and group B (N = 168) were comprised of subjects with normal and altered sperm parameters, respectively, from 18 to 60 years. The numbers of CAG and GGC repeats were determined by using PCR amplification and sequence analysis using the Molecular Evolutionary Genetic Analysis (MEGA) software version 6.0. Statistical analysis was performed using the SPSS version 20 and the P-value of <0.05 was considered significant. Results The mean androgen receptor gene CAG repeats were significantly longer in males with altered sperm parameters as compared to male subjects with normal sperm parameters (P < 0.001). There was no significant difference found for GGC repeats for subjects with altered sperm parameters. Conclusion Longer CAG length corresponded to greater severity of spermatogenic defect and may lead to subfertility recommendations.

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Section: Discussionmentioning

confidence: 99%

Association of trinucleotide repeat polymorphisms CAG and GGC in exon 1 of the androgen receptor gene with male infertility: a cross-sectional study

ASHRAF¹,

KAZMI²,

TARIQ³

et al. 2022

Turkish Journal of Medical Sciences

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show abstract

Advances in nanotechnology versus stem cell therapy for the theranostics of Huntington's disease

Mustafa

Hassan

Zeeshan

et al. 2023

Journal of Drug Delivery Science and Technology

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Association of trinucleotide repeat polymorphisms CAG and GGC in exon 1 of the Androgen Receptor gene with male infertility: a cross-sectional study

Ashraf¹,

Kazmi²,

Tariq³

et al. 2021

Turk J Med Sci

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Background/aim: Infertility is a global problem that brings about serious sexual and social consequences that strain the health sector and society. The expansion of CAG and GGC repeats in androgen receptor (AR) gene (Ensembl number ENSG00000169083) may lead to reduced fertility. Our objective was to determine the association of CAG and GGC repeats with altered sperm parameters in male infertile subjects.

show abstract

Molecular analysis and prevalence of Huntington disease in northwestern Iran

Cited by 3 publications

References 21 publications

Association of trinucleotide repeat polymorphisms CAG and GGC in exon 1 of the androgen receptor gene with male infertility: a cross-sectional study

Association of trinucleotide repeat polymorphisms CAG and GGC in exon 1 of the androgen receptor gene with male infertility: a cross-sectional study

Advances in nanotechnology versus stem cell therapy for the theranostics of Huntington's disease

Association of trinucleotide repeat polymorphisms CAG and GGC in exon 1 of the Androgen Receptor gene with male infertility: a cross-sectional study

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