Molecular analysis of the bacterial microbiota in duodenal biopsies from dogs with idiopathic inflammatory bowel disease

Suchodolski, Jan S.; Xenoulis, Panagiotis G.; Paddock, Casey G.; Steiner, Jörg M.; Jergens, Albert E.

doi:10.1016/j.vetmic.2009.11.002

Cited by 143 publications

(137 citation statements)

References 33 publications

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“…As in humans, an interplay between the intestinal microbiota together with an underlying genetic susceptibility of the host and dietary and environmental factors, are implicated in the development of disease [7,32]. While recent studies have reported a dysbiosis in duodenal samples of dogs with IBD, limited data are available describing the fecal microbiota in these dogs [7][8][9][10]. In this study, Faecalibacterium spp.…”

Section: Discussionmentioning

confidence: 85%

“…The intestinal microbiota has also been implicated in the pathogenesis of various canine GI disorders, either associated with the presence of specific pathogens (e.g., enterotoxigenic C. perfringens, Salmonella, viruses, and parasites) in acute episodes of diarrhea [5,6], or a non-specific dysbiosis such as that described in dogs with idiopathic inflammatory bowel disease [7][8][9][10]. Canine idiopathic IBD is one of the most common causes of chronic GI disease in dogs and encompasses a group of chronic enteropathies of unknown cause, which are characterized by infiltration of the intestinal mucosa with inflammatory cells [11].…”

Section: Introductionmentioning

confidence: 99%

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Fecal Microbiome in Dogs with Acute Diarrhea and Idiopathic Inflammatory Bowel Disease

Suchodolski

2015

Encyclopedia of Metagenomics

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Background: Recent molecular studies have revealed a highly complex bacterial assembly in the canine intestinal tract. There is mounting evidence that microbes play an important role in the pathogenesis of acute and chronic enteropathies of dogs, including idiopathic inflammatory bowel disease (IBD). The aim of this study was to characterize the bacterial microbiota in dogs with various gastrointestinal disorders.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Fecal Microbiome in Dogs with Acute Diarrhea and Idiopathic Inflammatory Bowel Disease

Suchodolski

2015

Encyclopedia of Metagenomics

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“…Alterations in the fecal bacterial microbiome have been found in dogs with CIE 63, 64, 65, 66. The most significant decreases were detected in Faecalibacterium spp.…”

Section: Biomarkers In Chronic Inflammatory Enteropathies Of Dogsmentioning

confidence: 99%

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Heilmann

Steiner

2018

Veterinary Internal Medicne

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108

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Chronic inflammatory enteropathies (CIE) in dogs are a group of disorders that are characterized by chronic persistent or recurrent signs of gastrointestinal disease and histologic evidence of mucosal inflammation. These CIEs are classified as either food‐responsive, antibiotic‐responsive, or immunosuppressant‐responsive enteropathy. Patients not clinically responding to immunomodulatory treatment are grouped as nonresponsive enteropathy and dogs with intestinal protein loss as protein‐losing enteropathy. Disease‐independent clinical scoring systems were established in dogs for assessment of clinical disease severity and patient monitoring during treatment. Histopathologic and routine clinicopathologic findings are usually not able to distinguish the subgroups of CIE. Treatment trials are often lengthy and further diagnostic tests are usually at least minimally invasive. Biomarkers that can aid in defining the presence of disease, site of origin, severity of the disease process, response to treatment, or a combination of these would be clinically useful in dogs with CIE. This article summarizes the following biomarkers that have been evaluated in dogs with CIE during the last decade, and critically evaluates their potential clinical utility in dogs with CIE: functional biomarkers (cobalamin, methylmalonic acid, folate, α1‐proteinase inhibitor, immunoglobulin A), biochemical biomarkers (C‐reactive protein, perinuclear anti‐neutrophilic cytoplasmic antibodies, 3‐bromotyrosine, N‐methylhistamine, calprotectin, S100A12, soluble receptor of advanced glycation end products, cytokines and chemokines, alkaline phosphatase), microbiomic biomarkers (microbiome changes, dysbiosis index), metabolomic biomarkers (serum metabolome), genetic biomarkers (genomic markers, gene expression changes), and cellular biomarkers (regulatory T cells). In addition, important performance criteria of diagnostic tests are briefly reviewed.

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“…It is well-known that injury to neurons causes an increase in the expression of neurotransmitters, which promote the regeneration of injured cells. Previous studies have documented the ability of PACAP to prevent apoptotic cell death and protect cortical neurons against glutamate-induced cytotoxity, dopaminergic neurons against 6-hydroxydopamine-induced cytotoxicity, cerebellar granule neurons against ethanol, an oxidative stress inducing cell death, as well as cerebral neurons during ischaemia (28)(29)(30). It is also known that PACAP (mainly via PAC1 receptor) affects proliferation of neurons, axon regeneration, and development of the nervous system (3).…”

Section: Discussionmentioning

confidence: 99%

Pituitary adenylate cyclase activating peptide-27 – like immunoreactive nerve fibers in the mucosal layer of canine gastrointestinal tract in physiology and during inflammatory bowel disease

Gonkowski

Rychlik

Całka

2013

Bulletin of the Veterinary Institute in Pulawy

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Changes in the density of mucosal pituitary adenylate cyclase activating peptide-27 -like immunoreactive (PACAP-27 -LI) nerve fibers within various parts of the canine gastrointestinal (GI) tract during inflammatory bowel disease (IBD) were investigated. The distribution of nerves were studied, using a single-labelling immunofluorescence technique, in the mucosal layer of canine stomach, duodenum, jejunum, and descending colon. Canine IBD caused an increase in the density of PACAP-27-LI mucosal nerves in all studied parts of GI tract. The results suggest that PACAP in the nervous system may be involved in pathological processes during IBD.

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Molecular analysis of the bacterial microbiota in duodenal biopsies from dogs with idiopathic inflammatory bowel disease

Cited by 143 publications

References 33 publications

Fecal Microbiome in Dogs with Acute Diarrhea and Idiopathic Inflammatory Bowel Disease

Fecal Microbiome in Dogs with Acute Diarrhea and Idiopathic Inflammatory Bowel Disease

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Pituitary adenylate cyclase activating peptide-27 – like immunoreactive nerve fibers in the mucosal layer of canine gastrointestinal tract in physiology and during inflammatory bowel disease

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