Molecular and biologic characterization of Leishmania parasites implicated in an epidemic outbreak in northwestern Argentina

Segura, Elsa L.; Juan, N.; Piquin, A. L. M.; Cuba, César Augusto Cuba; Orrego, L. Abramo; McMahon-Pratt, Diane; Montamat, Enrique E.; Momen, Hooman; Grimaldi, Gabriel

doi:10.1007/s004360050702

Cited by 20 publications

(16 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This parasite was isolated from human ACL cases during ACL outbreaks in Argentina, from ACL cases in Santiago del Estero, and from Lu. neivai caught in Tucumán (Cuba-Cuba et al 1996, Segura et al 2000, Cordoba-Lanus et al 2005. Lu.…”

Section: Discussionmentioning

confidence: 99%

Phlebotominae (Diptera: Psycodidae) fauna in the Chaco region and Cutaneous Leishmaniasis transmission patterns in Argentina

Salomón¹,

Rosa

Stein

et al. 2008

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Phlebotominae (Diptera: Psycodidae) fauna in the Chaco region and Cutaneous Leishmaniasis transmission patterns in Argentina

Salomón¹,

Rosa

Stein

et al. 2008

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…3 American tegumentary leishmaniasis is found from Mexico to northern Argentina. [4][5][6][7] In the province of Salta in northwestern Argentina, ATL is an endemic disease. In recent years, there has been a steady increase in the prevalence and/or recognition of the disease in this area, causing a negative socioeconomic impact.…”

mentioning

confidence: 99%

Use of kDNA-based Polymerase Chain Reaction as a Sensitive and Differentially Diagnostic Method of American Tegumentary Leishmaniasis in Disease-Endemic Areas of Northern Argentina

et al. 2007

View full text Add to dashboard Cite

We evaluated the polymerase chain reaction (PCR) for the diagnosis of endemic American Tegumentary Leishmaniasis in Salta, Argentina. Diverse Leishmania species, coexistence of mycotic and varicose ulcers, and high endemicity T. cruzi, represent diagnostic challenges in the region. We performed a simplified PCR using sensitive, generic primers on samples obtained by a non-invasive method. We tested different culture types and clinical specimens with other microorganisms that induce leishmaniasis-like lesions. The PCR had a sensitivity and specificity of 100%. Forty-five patients with presumptive leishmaniasis were compared to the PCR, smears, and the Montenegro skin test (MST). In the same population, the PCR had an increased sensitivity, detecting 25 of 45 cases compared with 16 of 45 for smears and had a higher sensitivity in detecting mucocutaneous lesions. Diagnosis by PCR was supported by clinical presentation, positive MST results, compatible epidemiology, and in some cases histopathologic results or isolation of parasites by culture. These findings indicate the convenience of incorporating this PCR into diagnostic strategies for detecting leishmaniasis in northern Argentina.

show abstract

“…In America tegumentary leishmaniasis (cutaneous and mucocutaneous) is endemic from the Yucatán peninsula to northern Argentina 10,35,37,39 . In Argentina this disease is endemic, and the parasite was identified as Leishmania (Viannia) braziliensis 2,8,12,34,35 . The first record in the country was in 1916, by PATERSON, in the province of Tucumán 3,36 , since then its vectorial transmission has been reported, in nine northwestern provinces: Jujuy, Salta, Tucumán, Santiago del Estero, Catamarca, Chaco, Formosa, Corrientes and Misiones 4,37 .…”

Section: Introductionmentioning

confidence: 99%

Phlebotominae fauna in the Province of Tucumán, Argentina

Córdoba-Lanús

Salomón

2002

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYAmerican Tegumentary Leishmaniasis is endemic in the province of Tucumán since 1916 where the first Argentinian case of leishmaniasis was reported. An epidemic outbreak took place in the province during 1986-1988, after that the number of cases increased gradually again between 1991-1996. Since October of 1999 sand flies captures were performed at different places associated with current and past transmission or sites identified as risky ones. The collections were carried out with CDC mini light trap and modified Shannon trap. In this study 2338 Phlebotominae were captured being prevalent Lutzomyia neivai (Lu intermedia complex) (97.7%), followed by Lu. migonei. We report Lu. shannoni for the first time in the province. Phlebotominae was abundant in the warm and humid months and showed a peak before the summer rains. Lutzomyia neivai showed a pattern (peridomestic prevalence, anthropophilia, abundance in secondary forest) consistent with other outbreak studies. Thus, the results reinforce this species incrimination as vector of leishmaniasis in the area. Domestic animals close to houses increase its abundance, and so the probable associated risk of human-Phlebotominae contact. Further studies should be done to understand the role of each Phlebotominae species in the transmission of leishmaniasis in Tucumán in order to design entomological surveillance strategies.

show abstract

Molecular and biologic characterization of Leishmania parasites implicated in an epidemic outbreak in northwestern Argentina

Cited by 20 publications

References 23 publications

Phlebotominae (Diptera: Psycodidae) fauna in the Chaco region and Cutaneous Leishmaniasis transmission patterns in Argentina

Phlebotominae (Diptera: Psycodidae) fauna in the Chaco region and Cutaneous Leishmaniasis transmission patterns in Argentina

Use of kDNA-based Polymerase Chain Reaction as a Sensitive and Differentially Diagnostic Method of American Tegumentary Leishmaniasis in Disease-Endemic Areas of Northern Argentina

Phlebotominae fauna in the Province of Tucumán, Argentina

Contact Info

Product

Resources

About