Molecular and biological functions of resveratrol in psychiatric disorders: a review of recent evidence

Shayganfard, Mehran

doi:10.1186/s13578-020-00491-3

Cited by 37 publications

(15 citation statements)

References 139 publications

(134 reference statements)

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“…For example, researchers demonstrated the polyphenol quercetin administered at 300 mg/kg had activity against anxiety [81]. Polyphen ol resveratrol has also been suggested to improve behavioral symptoms of anxiety and depression, as it has antiapoptotic, antioxidative and anti-in lammatory effects [82]. 50 mg -100 mg of lavonoids given as supplements for at least 8 weeks may be effective against depression and anxiety [83].…”

Section: Anxiety and Nutrientsmentioning

confidence: 99%

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Madireddy¹,

Madireddy²

2022

J Neurosci Neurol Disord

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Neurological disorders are a significant cause of mortality and disability across the world. The current aging population and population expansion have seen an increase in the prevalence of neurological and psychiatric disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis and schizophrenia. These pose a significant societal burden, especially in low - and middle-income countries. Many neurological disorders have complex mechanisms and lack definitive cures; thus, improving our understanding of them is essential. The pathophysiology of neurological disorders often includes inflammation, mitochondrial dysfunction and oxidative stress. Oxidative stress processes, especially the generation of reactive oxygen species, are key mechanisms in the development of neurological disorders. Oxidative stress refers to an imbalance between the production of reactive oxygen species and antioxidants that can counteract them. Through their impacts on the pathophysiology of neurological disorders, nutrients with anti-inflammatory, neuroprotective and antioxidative properties have been suggested to prevent or mitigate these disorders. Certain vitamins, minerals, polyphenols and flavonoids may have therapeutic effects as adjuvant treatments for neurological disorders. Diet quality is also a risk factor for some neurological and psychiatric disorders and addressing nutritional deficiencies may alleviate symptoms. Therefore, optimizing nutritional intake may represent a potential treatment or prevention strategy. This review summarizes a selection of promising nutrients for the prevention and amelioration of neurological disorders to provide a summary for scientists, clinicians and patients, which may improve understanding of the potential benefits of nutrients in the treatment of neurological disorders.

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Section: Anxiety and Nutrientsmentioning

confidence: 99%

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Madireddy¹,

Madireddy²

2022

J Neurosci Neurol Disord

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“…Hydroxytyrosol, another phenolic compound found at high doses in olive oil, has also reported substantial benefits in the management of depressive behaviors in mice models [ 255 ] and given the multiple benefits of this component in mental health and disease [ 256 , 257 ], we encourage for further research in this area. More evidence supports the use of resveratrol in animal models of MDD, acting mainly by the following mechanisms: regulation of HPA axis, increased BDNF activity, neurogenesis and monoamines production and decrease neuroinflammation, mitochondrial damage and oxidative stress [ 258 , 259 ]. However, similar to some of the previous bioactive compounds, the clinical application of resveratrol is quite limited and future studies will be critical to understand and prove the role of resveratrol in the clinical management of MDD.…”

Section: Nutraceuticals In Mddmentioning

confidence: 99%

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

et al. 2021

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Major depressive disorder (MDD) is a complex and common disorder, with many factors involved in its onset and development. The clinical management of this condition is frequently based on the use of some pharmacological antidepressant agents, together with psychotherapy and other alternatives in most severe cases. However, an important percentage of depressed patients fail to respond to the use of conventional therapies. This has created the urgency of finding novel approaches to help in the clinical management of those individuals. Nutraceuticals are natural compounds contained in food with proven benefits either in health promotion or disease prevention and therapy. A growing interest and economical sources are being placed in the development and understanding of multiple nutraceutical products. Here, we summarize some of the most relevant nutraceutical agents evaluated in preclinical and clinical models of depression. In addition, we will also explore less frequent but interest nutraceutical products which are starting to be tested, also evaluating future roads to cover in order to maximize the benefits of nutraceuticals in MDD.

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“…The most abundant stilbene was trans-isorhapontin in the bark (144.3 mg/g DW), which constituted 14.4% of the used bark mass and about 87.5% of all stilbenes in the bark (Table 1). , trans-and cis-piceid [3,6], trans-and cis-isorhapontin [4,7], trans-piceatannol [5], t and cis-resveratrol [8,10], and trans-and cis-isorhapontigenin [9,11]. Trans-astringin [1], trans-p [3], and trans-isorhapontin [4] marked with thick dotted lines because the content of these pounds is much higher than the other stilbenes.…”

Section: Stilbene Identification and Quantification In The Bark And Wood Of P Jezoensis By Hplc-ms-uvmentioning

confidence: 99%

“…Stilbenes are natural compounds occurring in a number of unrelated plant families, including Vitaceae (grape), Fabaceae (peanut), or Pinaceae (pine). Stilbenes, with the moststudied compound resveratrol (3,5,4 -trihydroxy-trans-stilbene), occupy a special place among the secondary metabolites of plants due to their well-known beneficial biological activities, including antioxidant, anticancer, antiviral, anti-inflammatory, anti-microbial, cardio-protective, neuroprotective, phytoestrogenic, and radioprotective properties [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Hypothetical biosynthetic pathway for stilbene formation in Pinaceae[25]. Circles with dotted lines depict 11 stilbenes detected in the needles of spruce Picea jezoensis: transand cisastringin [1,2], transand cis-piceid[3,6], transand cis-isorhapontin[4,7], trans-piceatannol[5], transand cis-resveratrol[8,10], and transand cis-isorhapontigenin[9,11]. Trans-astringin [1], transpiceid[3], and trans-isorhapontin[4] marked with thick dotted lines because the content of these compounds is much higher than the other stilbenes.…”

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confidence: 99%

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The Bark of the Spruce Picea jezoensis Is a Rich Source of Stilbenes

et al. 2021

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Stilbenes are plant phenolic secondary metabolites that show beneficial effects on human health and possess high antifungal activity against plant pathogens. Currently, a search for plant sources with high stilbene levels is relevant, since stilbene content in various plant species can vary substantially and is often at a low level. In this paper, the bark and wood of Picea jezoensis were analyzed for the content and composition of stilbenes and compared with other known stilbene sources. The HPLC-MS analysis of P. jezoensis bark and wood extracted with different solvents and at different temperatures revealed the presence of 11 and 5 stilbenes, respectively. The highest number of stilbenes of 171 and 229 mg per g of the dry weight (mg/g DW) was extracted from the bark of P. jezoensis using methanol or ethanol at 60 °C for 2 h. Trans-astringin, trans-piceid, and trans-isorhapontin prevailed over other stilbenoids (99% of all detected stilbenes). The most abundant stilbene was trans-isorhapontin, reaching 217 mg/g DW or 87% of all stilbenes. An increase in the extraction time from 2 to 6 h did not considerably increase the detected level of stilbenes, while lower extraction temperatures (20 and 40 °C) significantly lowered stilbene yield. The content of stilbenes in the P. jezoensis bark considerably exceeded stilbene levels in other stilbene-producing plant species. The present data revealed that the bark of P. jezoensis is a rich source of stilbenes (primarily trans-isorhapontin) and provided effective stilbene extraction procedures.

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Molecular and biological functions of resveratrol in psychiatric disorders: a review of recent evidence

Cited by 37 publications

References 139 publications

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

Exploring the Role of Nutraceuticals in Major Depressive Disorder (MDD): Rationale, State of the Art and Future Prospects

The Bark of the Spruce Picea jezoensis Is a Rich Source of Stilbenes

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