Molecular and cellular mechanisms of adipogenesis

Egorov, Alexander; Penkov, Dmitry; Ткачук, В. А.

doi:10.14341/dm2015212-19

Cited by 9 publications

(9 citation statements)

References 52 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Кроме того, существует положительная петля обратной связи между C/EBPα и PPARγ, она необходима для поддержания дифференцировки адипоцитов (рис. 4) [19,20].…”

Section: какие же изменения в ткани орбиты развиваются при гиперкортицизме?unclassified

“…Выявлено, что эктопическая экспрессия ADD1/SREBP1 в фибробластах способствует адипогенезу путем усиления активности PPARγ. Другие же исследования свидетельствуют о том, что ADD1/SREBP1 и C/EBPβ лишь повышают продукцию лигандов PPARγ [20]. При этом сам лиганд все еще не известен.…”

Section: какие же изменения в ткани орбиты развиваются при гиперкортицизме?unclassified

“…Инсулин, связываясь со своим рецептором, запускает внутриклеточный сигнальный каскад, приводящий к активации киназы Akt и фосфорилированию антиадипогенных транскрипционных факторов FOXO1 (forkhead box protein O1) и FOXA2 (forkhead box protein A2), что вызывает их выход из ядра и деактивацию [20]. Также инсулин является индуктором адипогенеза, он запускает фосфорилирование CREB, белка первой волны.…”

Section: роль инсулина ифр и глюкокортикоидов в регуляции адипогенезаunclassified

“…Транскрипционный фактор 2 (Runx2) и костный морфогенетический белок (КМБ)-2 являются остеогенными факторами. При активации адипоцитарного пути развития под влиянием кортизола и других стимулов они подавляются микроРНК [20]. Известно, что 204 и 30 микроРНК ингибируют Runx2, а 17-5p и 106а -КМБ-2.…”

Section: индукторы и ингибиторы адипогенезаunclassified

See 3 more Smart Citations

Orbital manifestations of hypercorticism

2021

View full text Add to dashboard Cite

Nowadays, Cushing's syndrome (hypercortisolism) and its manifestations are well studied. The main symptoms of hyper-cortisolism are obesity, osteoporosis, cardiomyopathy, muscle atrophy, skin thinning and purple stretch marks (striae) on the body. In practice, obesity and osteoporosis are the most frequent symptoms that are found in 90% of cases. However, there are some patients with an implicit clinical picture of hypercorticism. Some cases might concomitant with exophthalmos. This review describes a rare symptom of hypercortisolism — exophthalmos. Exophthalmos is a pathological protruding of eyeballs. This symptom is known in the context of TED that occurs most commonly in patients with Graves' disease. The article compares the mechanisms of development of eye symptoms in Cushing's syndrome and thyroid diseases, especially the Graves' disease. It discusses possible molecular mechanisms leading to exophthalmia in patients with Cushing's syndrome. Factors affecting adipogenesis in vitro and in vivo are studied, in particular factors leading to an increase of orbital fatty tissue against of elevated cortisol levels. Hormonal signaling and transcription cascades responsible for adipocyte differentiation into mature fat cells are presented. Other orbital manifestations of hypercortisolism, which occur relatively rare in practice, are also discussed in the article. These include glaucoma as well as cataract, Lisha nodules and central serous chorioretinopathy. Clinical cases of Cushing's syndrome with different ocular manifestations are considered and appropriate conclusions have been drawn.

show abstract

Section: какие же изменения в ткани орбиты развиваются при гиперкортицизме?unclassified

Section: роль инсулина ифр и глюкокортикоидов в регуляции адипогенезаunclassified

Section: индукторы и ингибиторы адипогенезаunclassified

See 2 more Smart Citations

Orbital manifestations of hypercorticism

2021

View full text Add to dashboard Cite

show abstract

“…Жировая ткань играет главную, «пусковую» роль в развитии МС [3,4], что диктует необходимость проведения комплексных морфологических исследований с целью изучения морфофункциональных особенностей жировой ткани при избыточной массе тела и ожирении у лиц с МС, что в дальнейшем будет способствовать как усовершенствованию известных, так и появлению новых методов лечения.…”

Section: Morphologia • 2016 • том 10 • № 3 • морфологіяunclassified

Immunohistochemical features of fat tissue of epiploon and subcutaneous fat tissue in patients with overweight, obesity and metabolic syndrome.

Militsa¹,

Sorokina²,

Myroshnychenko³

et al. 2016

Morphologia

View full text Add to dashboard Cite

медицинская академия последипломного образования МЗ Украины» 2 Харьковский национальный медицинский университет Ключевые слова: жировая ткань, сальник, подкожная жировая клетчатка, избыточная масса тела, ожирение, метаболический синдром, иммуногистохимия.

show abstract

The results of immunohistochemical study of antibodies to CYP11B2 in primary hyperaldosteronism

et al. 2021

View full text Add to dashboard Cite

Background: Aldosterone-producing adrenocortical adenoma (APA) is responsible for the majority of cases clinically diagnosed as primary aldosteronism. Aldosterone synthase (CYP11B2) is one of the enzymes that play essential roles in aldosterone synthesis and is involved in the pathogenesis of primary aldosteronism. Recent studies have demonstrated that various factors influence the expression and function of CYP11B2 in APA. In particular, somatic mutations, such as gain-of-function and loss-of-function mutations have been identified in several genes, each of which encodes a pivotal protein that affects the calcium signaling pathway, the expression of CYP11B2, and aldosterone production. On the other hand, CYP11B2 also catalyzes the conversion of cortisol to 18-hydroxycortisol and subsequently converts 18-hydroxycortisol to 18-oxocortisol. The article also discusses the clinical significance of 18-oxocortisol, an important biomarker for the diagnosis of primary aldosteronism. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, that indicating heterogeneous expression of CYP11B2 in tumor.Aim: to assess the functional heterogeneity of adrenal tumors in primary aldosteronismMaterials and methods: Retrospective evaluation adrenal tumors from patients with primary aldosteronism (n=20). According to CT unilateral macrohyperplasia was detected in 19 patients (95% of total), all of them were confirmed to have unilateral hyperproduction of aldosterone according to AVS. Selected tumors werestained with anty-CYP11B2 antibody. We evaluated the CYP11B2 expression in the adenoma and in the adjacent adrenal cortex.Results: Immunohistochemistry studies of the resected adrenals from 20 patients with PA operated due to unilateral production of aldosterone using CYP11B2 staining showed that 10 of those with an adenoma on CT scanning showed CYP11B2 staining in the adenoma. Furthermore, 5 cases of an unilateral adenoma, showed CYP11B2 staining in the adjacent adrenal cortex and an absence of staining for CYP11B2 in the adenoma. 5 cases showed CYP11B2 expression is heterogeneously immunolocalized throughout the tumor area.Conclusion: Thus, the functional heterogeneity of adrenal tumors in primary aldosteronism has been proven. It is necessary to compare the data of immunohistochemical studies on the expression of CYP11B2 with the indicators of the level of 18-hydroxycortisol, 18-oxocortisol.

show abstract

Molecular and cellular mechanisms of adipogenesis

Cited by 9 publications

References 52 publications

Orbital manifestations of hypercorticism

Orbital manifestations of hypercorticism

Immunohistochemical features of fat tissue of epiploon and subcutaneous fat tissue in patients with overweight, obesity and metabolic syndrome.

The results of immunohistochemical study of antibodies to CYP11B2 in primary hyperaldosteronism

Contact Info

Product

Resources

About