Molecular and cellular radiobiology of heavy ions

Tobias, Cornelius A.; Blakely, Eleanor A.; Alpen, Edward L.; Castro, Joseph R.; Ainsworth, E. J.; Curtis, Stanley B.; Ngo, Frank Q.H.; Rodriguez, A.; Roots, R.; Tenfordf, T.; Yang, T. C.

doi:10.1016/0360-3016(82)90554-5

Cited by 88 publications

(37 citation statements)

References 22 publications

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“…Furthermore, hypoxic cells naturally occur within cancerous tissues. Hypoxic cells are resistant to low-LET photons, but may be effectively killed by high-LET heavy ions (14,39). According to previous reports, it has been suggested that heavy ions may suppress the metastatic capabilities of cancer cells; thus, the effects of heavy ions on the control of lung metastasis of canine OSA should be investigated for clinical application (40,41).…”

Section: Discussionmentioning

confidence: 99%

“…A number of in vitro studies have demonstrated that high LET radiation is more effective than low LET radiation in terms of cell-killing effects (10)(11)(12)(13). Additionally, the extent of cell killing by heavy ions is not cell cycle dependent and is not decreased due to the presence of hypoxia (14)(15)(16). In human oncology, the relative biological effectiveness (RBE) is used to describe the increase in effectiveness of particle radiation (10,12).…”

Section: Introductionmentioning

confidence: 99%

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Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

et al. 2016

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Abstract. Heavy ions, characterized by high linear energy transfer (LET) radiation, have advantages compared with low LET protons and photons in their biological effects. The application of heavy ions within veterinary clinics requires additional background information to determine heavy ion efficacy. In the present study, comparison of the cell-killing effects of photons, protons and heavy ions was investigated in canine osteosarcoma (OSA) cells in vitro. A total of four canine OSA cell lines with various radiosensitivities were irradiated with 137 Cs gamma-rays, monoenergetic proton beams, 50 keV/µm carbon ion spread out Bragg peak beams and 200 keV/µm iron ion monoenergetic beams. Clonogenic survival was examined using colony-forming as says, and relative biological effectiveness (RBE) values were calculated relative to gamma-rays using the D 10 value, which is determined as the dose (Gy) resulting in 10% survival. For proton irradiation, the RBE values for all four cell lines were 1.0-1.1. For all four cell lines, exposure to carbon ions yielded a decreased cell survival compared with gamma-rays, with the RBE values ranging from 1.56-2.10. Iron ions yielded the lowest cell survival among tested radiation types, with RBE values ranging from 3.51-3.69 observed in the three radioresistant cell lines. The radiosensitive cell line investigated demonstrated similar cell survival for carbon and iron ion irradiation. The results of the present study suggest that heavy ions are more effective for killing radioresistant canine OSA cells when compared with gamma-rays and protons. This markedly increased efficiency of cell killing is an attractive reason for utilizing heavy ions for radioresistant canine OSA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

et al. 2016

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“…In terms of high relative biologic effectiveness and reduced oxygen-enhancement ratio in the tumour, hadron therapy provides biologic and physical advantages over photon therapy 21 . Many studies [22][23][24][25] have demonstrated the use of hadron therapy in chordomas of the skull base, cervical spine, and sacrococcygeal region, with local control at 5 years being 50%-60%, leading to uniform agreement that hadron therapy seems to be at least as effective as photon therapy.…”

Section: Discussionmentioning

confidence: 99%

Synchronous Metastatic Skull Base Chordoma to the Breast: Case Report and Literature Review

et al. 2016

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Clinical Scenario During routine staging work-up for a left breast mass, a 68-year-old woman complained of dysphagia and dysphonia. During further investigations, a left-sided lesion at the foramen magnum was observed on brain imaging. Both lesions were biopsied and showed a classical chordoma. ManagementThe skull-base lesion and the breast lesion were surgically resected, and adjuvant radiotherapy was given.Summary Chordoma is a rare primary central nervous system tumour that seldom metastasizes. The lung is the most common site of metastasis. Synchronous breast metastasis from a skull-base chordoma is very rare, and a safe management option includes a maximum resection followed by adjuvant radiotherapy.

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“…One study suggested that localized high-dose radiation therapy can improve the efficacy of radiation therapy [8], and ion beams can provide a better dose concentration then can photon beams [10,11]. Indeed, ion beams are considered a highly effective treatment for cancer due to their higher relative biological effectiveness (RBE) [12,13].…”

Section: Introductionmentioning

confidence: 99%

Preliminary study of apparent diffusion coefficient assessment after ion beam therapy for hepatocellular carcinoma

Kanamoto

Miyati

Terashima

et al. 2016

Radiol Phys Technol

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We evaluated the state of hepatocellular carcinoma (HCC) and the liver after ion beam therapy by analyzing the apparent diffusion coefficient (ADC). In this retrospective study, we evaluated 13 HCC lesions in 10 patients who underwent magnetic resonance imaging before and after therapy. Diffusion-weighted imaging was performed with use of b values of 0, 150, and 800 s/mm 2 . The ADC was determined for the tumor, irradiated liver, and normal liver. The maximum size of the tumor was measured, and reduction in tumor size was determined as a ratio of the maximum size of the diameter of the tumor. We compared the ADC before and after the therapy with the reduction in tumor size ratio. The reduction in tumor size ratio was compared with the ADCs of the tumors. The ADC of the tumor and the irradiated liver were significantly higher after therapy than before therapy. The ADC of the normal liver was not significantly different before and after therapy. The reduction ratio increased significantly (R = 0.73, P = 0.006) after therapy at the second follow-up when compared with after therapy at the first follow-up. No correlation was found between the reduction ratio and the ADC of the tumor in each follow-up. Inflammation of the liver occurs after treatment as a result of radiation doses from the ion beam, and the tumor reaches a state of necrosis. ADC value analysis provides a non-invasive assessment and yields focal information regarding the tumor and liver before and after ion beam therapy.

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Molecular and cellular radiobiology of heavy ions

Cited by 88 publications

References 22 publications

Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

Synchronous Metastatic Skull Base Chordoma to the Breast: Case Report and Literature Review

Preliminary study of apparent diffusion coefficient assessment after ion beam therapy for hepatocellular carcinoma

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