Synchronous Metastatic Skull Base Chordoma to the Breast: Case Report and Literature Review

Abstract

Clinical Scenario During routine staging work-up for a left breast mass, a 68-year-old woman complained of dysphagia and dysphonia. During further investigations, a left-sided lesion at the foramen magnum was observed on brain imaging. Both lesions were biopsied and showed a classical chordoma. ManagementThe skull-base lesion and the breast lesion were surgically resected, and adjuvant radiotherapy was given.Summary Chordoma is a rare primary central nervous system tumour that seldom metastasizes. The lung is the most common site of metastasis. Synchronous breast metastasis from a skull-base chordoma is very rare, and a safe management option includes a maximum resection followed by adjuvant radiotherapy.

Metastatic skull base chordoma: A systematic review

“…Finally, there were 38 studies included in this review, with a total of 40 included cases. 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 Study dates ranged from 1949–2022, with 10 studies being published prior to the 21st century. There were 9, 15, and 4 studies that were published between 2000–2009, 2010–2019, and 2020 onwards, respectively.…”

“…Two titles were found to be journal supplements and were excluded. Finally, there were 38 studies included in this review, with a total of 40 included cases 11–49 . Study dates ranged from 1949–2022, with 10 studies being published prior to the 21st century.…”