Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventions

Siddhartha, Rohit; Garg, Minal

doi:10.1016/j.taap.2021.115593

Cited by 34 publications

(23 citation statements)

References 74 publications

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“…Upregulation of interstitial marker proteins N-cadherin and vimentin causes the cells to acquire interstitial phenotypes and move easily [ 46 ]. MMPs degrade the extracellular matrix, which is beneficial to invasion and metastasis of malignant tumor cells [ 47 ].…”

Section: Curcumin In Treatment Of Malignant Tumorsmentioning

confidence: 99%

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health

Liu

et al. 2022

Molecules

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Curcumin is the most important active component in turmeric extracts. Curcumin, a natural monomer from plants has received a considerable attention as a dietary supplement, exhibiting evident activity in a wide range of human pathological conditions. In general, curcumin is beneficial to human health, demonstrating pharmacological activities of anti-inflammation and antioxidation, as well as antitumor and immune regulation activities. Curcumin also presents therapeutic potential in neurodegenerative, cardiovascular and cerebrovascular diseases. In this review article, we summarize the advancements made in recent years with respect to curcumin as a biologically active agent in malignant tumors, Alzheimer’s disease (AD), hematological diseases and viral infectious diseases. We also focus on problems associated with curcumin from basic research to clinical translation, such as its low solubility, leading to poor bioavailability, as well as the controversy surrounding the association between curcumin purity and effect. Through a review and summary of the clinical research on curcumin and case reports of adverse effects, we found that the clinical transformation of curcumin is not successful, and excessive intake of curcumin may have adverse effects on the kidneys, heart, liver, blood and immune system, which leads us to warn that curcumin has a long way to go from basic research to application transformation.

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Section: Curcumin In Treatment Of Malignant Tumorsmentioning

confidence: 99%

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health

Liu

et al. 2022

Molecules

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“…Moreover, the angiogenic switch and the tumor neovascularization may be due to hypoxic conditions or the consequence of therapies promoting tumor progression [ 12 ]. Various studies have demonstrated the key participation of MMPs along with EMT to promote angiogenesis, infiltration by cancer cells, and metastasis [ 79 ]. MMPs participate in the degradation of ECM components, including the basement membrane and the tumor surface, resulting in tumor cell migration into the near tissue.…”

Section: Roles Of Mir-29b In Breast Cancermentioning

confidence: 99%

Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

2022

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The miR-29 family comprises miR-29a, miR-29b, and miR-29c, and these molecules play crucial and partially overlapped functions in solid tumors, in which the different isoforms are variously de-regulated and mainly correlated with tumor suppression. miR-29b is the most expressed family member in cancer, in which it is involved in regulating gene expression at both transcriptional and post-transcriptional levels. This review focuses on the role of miR-29b in breast cancer, in which it plays a controversial role as tumor suppressor or onco-miRNA. Here we have highlighted the dual effect of miR-29b on breast tumor features, which depend on the prevailing function of this miRNA, on the mature miR-29b evaluated, and on the breast tumor characteristics. Remarkably, the analyzed miR-29b form emerged as a crucial element in the results obtained by various research groups, as the most abundant miR-29b-3p and the less expressed miR-29b1-5p seem to play distinct roles in breast tumors with different phenotypes. Of particular interest are the data showing that miR-29b1-5p counteracts cell proliferation and migration and reduces stemness in breast tumor cells with a triple negative phenotype. Even if further studies are required to define exactly the role of each miR-29b, our review highlights its possible implication in phenotype-specific management of breast tumors.

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“…Metalloproteinases (MMPs, ADAMs and ADAMTSs) collectively cleave a large array of ECM substrates including proteoglycans, collagens and membrane-associated protein substrates such as cytokines (Black et al, 1997;Khatwa et al, 2010). Functionally, MMPs are responsible for regulating and degrading a variety of ECM components including collagen, elastin, and gelatin and contribute to regulation of cytokine expression (Ra and Parks, 2007;Siddhartha and Garg, 2021). Similarly, ADAMs cleave and release soluble factors like chemokines (Reiss and Saftig, 2009), mediate shedding of membrane-associated proteins into their active forms (i.e.…”

Section: Function Structure and Regulation Of Zinc-dependent Metalloproteinases Functionmentioning

confidence: 99%

Extracellular Matrix Enzymes and Immune Cell Biology

McMahon

Pedrina

et al. 2021

Front. Mol. Biosci.

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Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.

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Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventions

Cited by 34 publications

References 74 publications

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health

Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

Extracellular Matrix Enzymes and Immune Cell Biology

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